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Article: Comparative genomic hybridization: the profile of chromosomal imbalances in esophageal squamous cell carcinoma

TitleComparative genomic hybridization: the profile of chromosomal imbalances in esophageal squamous cell carcinoma
Authors
Issue Date2005
Citation
Zhonghua Bing Li Xue Za Zhi Chinese Journal Of Pathology, 2005, v. 34 n. 2, p. 80-83 How to Cite?
AbstractOBJECTIVE: To characterize the profile of chromosomal imbalances of esophageal squamous cell carcinoma (SCC) in Linzhou, the high prevalence area of Henan province. METHODS: Comparative genomic hybridization (CGH) was used to examine 52 cases of primary SCC of esophagus. RESULTS: Gains in part or in whole of chromosome 3q, 8q, 5p, 1q, 6q, 18p, 20q and losses of 3p, 1p, 9q, 19p, 4p, 8p were detected frequently in SCC (> 20%). Gain of 3q, 5p, 1q, 11q13-14 and loss of 4pq, 13q were all significantly correlated with pathologic staging (P < 0.05). Gains of 8q, loss of 4p were linked to nodal metastasis (P < 0.05). Gains of 2p and loss of 4pq, 11q14-qter were associated with distant organ metastasis (P < 0.05). CONCLUSION: These observations suggest that 3q, 8q, 5p, 1q, 6q, 18p, and 20q may contain SCC-related oncogenes; 3p, 1p, 9q, 19p, 4p and 8p may contain SCC-related tumor suppressor genes. It is likely that gain of 3q, 5p, 1q, 11q13-14 and loss of 4pq, 13q are the genetic aberrations critical for the development of esophageal carcinoma, whereas gains of 8q, 2p and loss of 4pq, 11q14-qter are considered later events associated with tumor progression and are thought to confer metastatic potential to esophageal carcinoma. Furthermore, nodal and distant organ metastases involve different genes.
Persistent Identifierhttp://hdl.handle.net/10722/72037
ISSN
2015 SCImago Journal Rankings: 0.136

 

DC FieldValueLanguage
dc.contributor.authorQin, YRen_HK
dc.contributor.authorWang, LDen_HK
dc.contributor.authorKwong, Den_HK
dc.contributor.authorGao, SSen_HK
dc.contributor.authorGuan, XYen_HK
dc.contributor.authorZhuang, ZHen_HK
dc.contributor.authorFan, ZMen_HK
dc.contributor.authorDeng, Wen_HK
dc.contributor.authorHu, Len_HK
dc.date.accessioned2010-09-06T06:37:44Z-
dc.date.available2010-09-06T06:37:44Z-
dc.date.issued2005en_HK
dc.identifier.citationZhonghua Bing Li Xue Za Zhi Chinese Journal Of Pathology, 2005, v. 34 n. 2, p. 80-83en_HK
dc.identifier.issn0529-5807en_HK
dc.identifier.urihttp://hdl.handle.net/10722/72037-
dc.description.abstractOBJECTIVE: To characterize the profile of chromosomal imbalances of esophageal squamous cell carcinoma (SCC) in Linzhou, the high prevalence area of Henan province. METHODS: Comparative genomic hybridization (CGH) was used to examine 52 cases of primary SCC of esophagus. RESULTS: Gains in part or in whole of chromosome 3q, 8q, 5p, 1q, 6q, 18p, 20q and losses of 3p, 1p, 9q, 19p, 4p, 8p were detected frequently in SCC (> 20%). Gain of 3q, 5p, 1q, 11q13-14 and loss of 4pq, 13q were all significantly correlated with pathologic staging (P < 0.05). Gains of 8q, loss of 4p were linked to nodal metastasis (P < 0.05). Gains of 2p and loss of 4pq, 11q14-qter were associated with distant organ metastasis (P < 0.05). CONCLUSION: These observations suggest that 3q, 8q, 5p, 1q, 6q, 18p, and 20q may contain SCC-related oncogenes; 3p, 1p, 9q, 19p, 4p and 8p may contain SCC-related tumor suppressor genes. It is likely that gain of 3q, 5p, 1q, 11q13-14 and loss of 4pq, 13q are the genetic aberrations critical for the development of esophageal carcinoma, whereas gains of 8q, 2p and loss of 4pq, 11q14-qter are considered later events associated with tumor progression and are thought to confer metastatic potential to esophageal carcinoma. Furthermore, nodal and distant organ metastases involve different genes.en_HK
dc.languageengen_HK
dc.relation.ispartofZhonghua bing li xue za zhi Chinese journal of pathologyen_HK
dc.subject.meshCarcinoma, Squamous Cell - geneticsen_HK
dc.subject.meshChromosome Aberrationsen_HK
dc.subject.meshChromosome Deletionen_HK
dc.subject.meshChromosomes, Human, Pair 3en_HK
dc.subject.meshChromosomes, Human, Pair 4en_HK
dc.subject.meshChromosomes, Human, Pair 8en_HK
dc.subject.meshEsophageal Neoplasms - geneticsen_HK
dc.subject.meshGene Amplificationen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLymphatic Metastasisen_HK
dc.subject.meshNeoplasm Metastasis - geneticsen_HK
dc.subject.meshNeoplasm Stagingen_HK
dc.subject.meshNucleic Acid Hybridizationen_HK
dc.titleComparative genomic hybridization: the profile of chromosomal imbalances in esophageal squamous cell carcinomaen_HK
dc.typeArticleen_HK
dc.identifier.emailKwong, D: dlwkwong@hku.hken_HK
dc.identifier.emailGuan, XY: xyguan@hkucc.hku.hken_HK
dc.identifier.emailDeng, W: wdeng@hkucc.hku.hken_HK
dc.identifier.authorityKwong, D=rp00414en_HK
dc.identifier.authorityGuan, XY=rp00454en_HK
dc.identifier.authorityDeng, W=rp01640en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid15842801-
dc.identifier.scopuseid_2-s2.0-34548074120en_HK
dc.identifier.hkuros101415en_HK
dc.identifier.volume34en_HK
dc.identifier.issue2en_HK
dc.identifier.spage80en_HK
dc.identifier.epage83en_HK
dc.identifier.scopusauthoridQin, YR=7403100680en_HK
dc.identifier.scopusauthoridWang, LD=12242861000en_HK
dc.identifier.scopusauthoridKwong, D=15744231600en_HK
dc.identifier.scopusauthoridGao, SS=36079553800en_HK
dc.identifier.scopusauthoridGuan, XY=7201463221en_HK
dc.identifier.scopusauthoridZhuang, ZH=7203003327en_HK
dc.identifier.scopusauthoridFan, ZM=7402099547en_HK
dc.identifier.scopusauthoridDeng, W=7202223673en_HK
dc.identifier.scopusauthoridHu, L=25958137600en_HK

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