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Article: Chromosome 8p deletion is associated with metastasis of human hepatocellular carcinoma when high and low metastatic models are compared

TitleChromosome 8p deletion is associated with metastasis of human hepatocellular carcinoma when high and low metastatic models are compared
Authors
Issue Date2001
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00432/index.htm
Citation
Journal Of Cancer Research And Clinical Oncology, 2001, v. 127 n. 8, p. 482-488 How to Cite?
AbstractRecently, we found that chromosome 8p deletion might be associated with hepatocellular carcinoma (HCC) metastasis by analyzing the differences in chromosomal alterations between primary tumors and their matched metastatic lesions of HCC with comparative genomic hybridization (CGH) (Qin et al. 1999). To further confirm this interesting finding, the genomic changes of two models bearing human HCC with different metastatic potentials (LCI-D20 and LCI-D35), and the new human HCC cell line with high metastatic potential (MHCC97) were analyzed by CGH. Gains on 1q, 6q, 7p, and 8q, and losses on 13p, 14p, 19p, 21, and 22 were detected in both LCI-D20 and LCI-D35 models. However, high copy number amplification of a minimum region at 1q12-q22 and 12q, and deletions on 1p32-pter, 3p21-pter, 8p, 9p, 10q, 14q, and 15p were detected only in the LCI-D20 model. Gains on 1p21-p32, 2p13-p21, 6p12-pter, 9p, 15q, and 16q11-q21, and losses on 2p23-pter, 4q24-qter, 7q31-qter, 12q, 17p, and 18 were detected only in the LCI-D35 model. The chromosomal aberration patterns in the MHCC97 cell line were similar to its parent LCI-D20 model, except that gains on 19q and losses on 4, 5, 10q, and 13q were found only in the cell line. These results provide some indirect clues to the metastasis-related chromosomal aberrations of HCC and further support the finding that 8p deletion is associated with HCC metastasis, 1q12-22 and 12q might harbor a novel oncogene(s) that contributes to the development and progression of HCC. Amplification on 8q and deletions on 4q and 17p may be not necessary for HCC metastasis.
Persistent Identifierhttp://hdl.handle.net/10722/72032
ISSN
2015 Impact Factor: 3.141
2015 SCImago Journal Rankings: 1.190
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorQin, LXen_HK
dc.contributor.authorTang, ZYen_HK
dc.contributor.authorYe, SLen_HK
dc.contributor.authorLiu, YKen_HK
dc.contributor.authorMa, ZCen_HK
dc.contributor.authorZhou, XDen_HK
dc.contributor.authorWu, ZQen_HK
dc.contributor.authorLin, ZYen_HK
dc.contributor.authorSun, FXen_HK
dc.contributor.authorTian, Jen_HK
dc.contributor.authorGuan, XYen_HK
dc.contributor.authorPack, SDen_HK
dc.contributor.authorZhuang, ZPen_HK
dc.date.accessioned2010-09-06T06:37:41Z-
dc.date.available2010-09-06T06:37:41Z-
dc.date.issued2001en_HK
dc.identifier.citationJournal Of Cancer Research And Clinical Oncology, 2001, v. 127 n. 8, p. 482-488en_HK
dc.identifier.issn0171-5216en_HK
dc.identifier.urihttp://hdl.handle.net/10722/72032-
dc.description.abstractRecently, we found that chromosome 8p deletion might be associated with hepatocellular carcinoma (HCC) metastasis by analyzing the differences in chromosomal alterations between primary tumors and their matched metastatic lesions of HCC with comparative genomic hybridization (CGH) (Qin et al. 1999). To further confirm this interesting finding, the genomic changes of two models bearing human HCC with different metastatic potentials (LCI-D20 and LCI-D35), and the new human HCC cell line with high metastatic potential (MHCC97) were analyzed by CGH. Gains on 1q, 6q, 7p, and 8q, and losses on 13p, 14p, 19p, 21, and 22 were detected in both LCI-D20 and LCI-D35 models. However, high copy number amplification of a minimum region at 1q12-q22 and 12q, and deletions on 1p32-pter, 3p21-pter, 8p, 9p, 10q, 14q, and 15p were detected only in the LCI-D20 model. Gains on 1p21-p32, 2p13-p21, 6p12-pter, 9p, 15q, and 16q11-q21, and losses on 2p23-pter, 4q24-qter, 7q31-qter, 12q, 17p, and 18 were detected only in the LCI-D35 model. The chromosomal aberration patterns in the MHCC97 cell line were similar to its parent LCI-D20 model, except that gains on 19q and losses on 4, 5, 10q, and 13q were found only in the cell line. These results provide some indirect clues to the metastasis-related chromosomal aberrations of HCC and further support the finding that 8p deletion is associated with HCC metastasis, 1q12-22 and 12q might harbor a novel oncogene(s) that contributes to the development and progression of HCC. Amplification on 8q and deletions on 4q and 17p may be not necessary for HCC metastasis.en_HK
dc.languageengen_HK
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00432/index.htmen_HK
dc.relation.ispartofJournal of Cancer Research and Clinical Oncologyen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshCarcinoma, Hepatocellular - genetics - secondaryen_HK
dc.subject.meshChromosome Deletionen_HK
dc.subject.meshChromosomes, Human, Pair 1 - geneticsen_HK
dc.subject.meshChromosomes, Human, Pair 17 - geneticsen_HK
dc.subject.meshChromosomes, Human, Pair 6 - geneticsen_HK
dc.subject.meshChromosomes, Human, Pair 8 - geneticsen_HK
dc.subject.meshDisease Models, Animalen_HK
dc.subject.meshHumansen_HK
dc.subject.meshIn Situ Hybridization, Fluorescenceen_HK
dc.subject.meshInterphaseen_HK
dc.subject.meshLiver Neoplasms - genetics - pathologyen_HK
dc.subject.meshMiceen_HK
dc.subject.meshMice, Nudeen_HK
dc.titleChromosome 8p deletion is associated with metastasis of human hepatocellular carcinoma when high and low metastatic models are compareden_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0171-5216&volume=127&spage=482&epage=488&date=2001&atitle=Chromosome+8p+deletion+is+associated+with+metastasis+of+human+hepatocellular+carcinoma+when+high+and+low+metastatic+models+are+compareden_HK
dc.identifier.emailGuan, XY:xyguan@hkucc.hku.hken_HK
dc.identifier.authorityGuan, XY=rp00454en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s004320100236en_HK
dc.identifier.pmid11501747-
dc.identifier.scopuseid_2-s2.0-0034924603en_HK
dc.identifier.hkuros72265en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034924603&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume127en_HK
dc.identifier.issue8en_HK
dc.identifier.spage482en_HK
dc.identifier.epage488en_HK
dc.identifier.isiWOS:000170120800004-
dc.publisher.placeGermanyen_HK
dc.identifier.scopusauthoridQin, LX=16747601200en_HK
dc.identifier.scopusauthoridTang, ZY=7403306295en_HK
dc.identifier.scopusauthoridYe, SL=7202088340en_HK
dc.identifier.scopusauthoridLiu, YK=7410217338en_HK
dc.identifier.scopusauthoridMa, ZC=7403600424en_HK
dc.identifier.scopusauthoridZhou, XD=7410093101en_HK
dc.identifier.scopusauthoridWu, ZQ=7501414180en_HK
dc.identifier.scopusauthoridLin, ZY=7404229670en_HK
dc.identifier.scopusauthoridSun, FX=7401804164en_HK
dc.identifier.scopusauthoridTian, J=25642235800en_HK
dc.identifier.scopusauthoridGuan, XY=7201463221en_HK
dc.identifier.scopusauthoridPack, SD=7006668278en_HK
dc.identifier.scopusauthoridZhuang, ZP=7203003412en_HK

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