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Article: Clinicopathological significance of missing in metastasis B expression in hepatocellular carcinoma

TitleClinicopathological significance of missing in metastasis B expression in hepatocellular carcinoma
Authors
KeywordsHepatocellular carcinoma
MIM-B
Real-time quantitative PC
Issue Date2007
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/humpath
Citation
Human Pathology, 2007, v. 38 n. 8, p. 1201-1206 How to Cite?
AbstractMissing in metastasis (MIM) proteins are important regulators in controlling cell growth and development. There has been accumulating evidence suggesting a role of MIM-B in carcinogenesis, yet its role in the development of hepatocellular carcinoma has not been examined thus far. In this study, we investigated the clinicopathological significance of MIM-B in tumor and its matched adjacent nontumor tissue obtained from 40 patients with hepatocellular carcinoma. Increased MIM-B messenger RNA and protein expression, as detected by quantitative real-time polymerase chain reaction and Western blot, respectively, was found in hepatocellular carcinoma clinical samples; and its expression was significantly associated with early pathologic tumor-node-metastasis stage group (P = .007), presence of tumor encapsulation (P = .034), and absence of venous infiltration (P = .038). Higher levels of MIM-B expression were found to be associated with early stage disease. Elevated MIM-B expression may influence the development of hepatocellular carcinoma and may possibly be a powerful indicator for the disease at an early stage. © 2007 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/72030
ISSN
2015 Impact Factor: 2.791
2015 SCImago Journal Rankings: 1.363
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMa, Sen_HK
dc.contributor.authorGuan, XYen_HK
dc.contributor.authorLee, TKen_HK
dc.contributor.authorChan, KWen_HK
dc.date.accessioned2010-09-06T06:37:40Z-
dc.date.available2010-09-06T06:37:40Z-
dc.date.issued2007en_HK
dc.identifier.citationHuman Pathology, 2007, v. 38 n. 8, p. 1201-1206en_HK
dc.identifier.issn0046-8177en_HK
dc.identifier.urihttp://hdl.handle.net/10722/72030-
dc.description.abstractMissing in metastasis (MIM) proteins are important regulators in controlling cell growth and development. There has been accumulating evidence suggesting a role of MIM-B in carcinogenesis, yet its role in the development of hepatocellular carcinoma has not been examined thus far. In this study, we investigated the clinicopathological significance of MIM-B in tumor and its matched adjacent nontumor tissue obtained from 40 patients with hepatocellular carcinoma. Increased MIM-B messenger RNA and protein expression, as detected by quantitative real-time polymerase chain reaction and Western blot, respectively, was found in hepatocellular carcinoma clinical samples; and its expression was significantly associated with early pathologic tumor-node-metastasis stage group (P = .007), presence of tumor encapsulation (P = .034), and absence of venous infiltration (P = .038). Higher levels of MIM-B expression were found to be associated with early stage disease. Elevated MIM-B expression may influence the development of hepatocellular carcinoma and may possibly be a powerful indicator for the disease at an early stage. © 2007 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/humpathen_HK
dc.relation.ispartofHuman Pathologyen_HK
dc.subjectHepatocellular carcinomaen_HK
dc.subjectMIM-Ben_HK
dc.subjectReal-time quantitative PCen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshBlotting, Westernen_HK
dc.subject.meshCarcinoma, Hepatocellular - genetics - metabolism - secondaryen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGene Expressionen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLiver Neoplasms - genetics - metabolism - pathologyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMicrofilament Proteins - genetics - metabolismen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshNeoplasm Proteins - genetics - metabolismen_HK
dc.subject.meshNeoplasm Stagingen_HK
dc.subject.meshRNA, Messenger - metabolismen_HK
dc.subject.meshRNA, Neoplasm - analysisen_HK
dc.subject.meshReverse Transcriptase Polymerase Chain Reactionen_HK
dc.subject.meshTumor Markers, Biological - metabolismen_HK
dc.titleClinicopathological significance of missing in metastasis B expression in hepatocellular carcinomaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0046-8177&volume=38&issue=8&spage=1201&epage=6&date=2007&atitle=Clinicopathological+significance+of+missing+in+metastasis+B+expression+in+hepatocellular+carcinomaen_HK
dc.identifier.emailMa, S:sma@pathology.hku.hken_HK
dc.identifier.emailGuan, XY:xyguan@hkucc.hku.hken_HK
dc.identifier.emailLee, TK:tkwlee@hkucc.hku.hken_HK
dc.identifier.emailChan, KW:hrmtckw@hku.hken_HK
dc.identifier.authorityMa, S=rp00506en_HK
dc.identifier.authorityGuan, XY=rp00454en_HK
dc.identifier.authorityLee, TK=rp00447en_HK
dc.identifier.authorityChan, KW=rp00330en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.humpath.2007.01.004en_HK
dc.identifier.pmid17442377-
dc.identifier.scopuseid_2-s2.0-34447331286en_HK
dc.identifier.hkuros133139en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34447331286&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume38en_HK
dc.identifier.issue8en_HK
dc.identifier.spage1201en_HK
dc.identifier.epage1206en_HK
dc.identifier.isiWOS:000248339300012-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridMa, S=16444895800en_HK
dc.identifier.scopusauthoridGuan, XY=7201463221en_HK
dc.identifier.scopusauthoridLee, TK=7501439435en_HK
dc.identifier.scopusauthoridChan, KW=16444133100en_HK

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