Article: Recurrent chromosome changes in 62 primary gastric carcinomas detected by comparative genomic hybridization

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TitleRecurrent chromosome changes in 62 primary gastric carcinomas detected by comparative genomic hybridization
AuthorsGuan, XY4
Fu, SB2
Xia, JC2
Fang, Y5
Sham, JST4
Du, BD1
Zhou, H3
Lu, S2
Wang, BQ2
Lin, YZ5
Liang, Q5
Li, XM1
Du, B1
Ning, XM2
Du, JR
Li, P2
Trent, JM3
Issue Date2000
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergene
CitationCancer Genetics And Cytogenetics, 2000, v. 123 n. 1, p. 27-34 [How to Cite?]
DOI: http://dx.doi.org/10.1016/S0165-4608(00)00306-X
AbstractComparative genomic hybridization (CGH) has been applied to detect recurrent chromosome alterations in 62 primary gastric carcinomas. Several nonrandom chromosomal changes, including gains of 8q (31 cases, 50%), 20q (29 cases, 47%) with a minimum gain region at 20q11.2-q12, 13q (21 cases, 34%) with a minimum gain region at 13q22, and 3q (19 cases, 31%) were commonly observed. The regions most frequently lost included: 19p (23 cases, 37%), 17p (21 cases, 33%), and 1p (14 cases, 23%). High copy number gain (DNA sequence amplification) was detected in 6 cases. Amplification of 8q23-q24.2 and 20q11.2-q12 were observed in 3 cases. Gain of 20q and loss of 19p were confirmed by fluorescence in situ hybridization using corresponding bacterial artificial chromosomes (BAC) clones from those regions. The gain and loss of chromosomal regions identified in this study provide candidate regions involved in gastric tumorigenesis. Copyright (C) 2000 Elsevier Science Inc.
ISSN0165-4608
2011 Impact Factor: 1.389
2011 SCImago Journal Rankings: 0.162
DOIhttp://dx.doi.org/10.1016/S0165-4608(00)00306-X
ISI Accession Number IDWOS:000165915800002
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorGuan, XY
dc.contributor.authorFu, SB
dc.contributor.authorXia, JC
dc.contributor.authorFang, Y
dc.contributor.authorSham, JST
dc.contributor.authorDu, BD
dc.contributor.authorZhou, H
dc.contributor.authorLu, S
dc.contributor.authorWang, BQ
dc.contributor.authorLin, YZ
dc.contributor.authorLiang, Q
dc.contributor.authorLi, XM
dc.contributor.authorDu, B
dc.contributor.authorNing, XM
dc.contributor.authorDu, JR
dc.contributor.authorLi, P
dc.contributor.authorTrent, JM
dc.date.accessioned2010-09-06T06:37:38Z
dc.date.available2010-09-06T06:37:38Z
dc.date.issued2000
dc.description.abstractComparative genomic hybridization (CGH) has been applied to detect recurrent chromosome alterations in 62 primary gastric carcinomas. Several nonrandom chromosomal changes, including gains of 8q (31 cases, 50%), 20q (29 cases, 47%) with a minimum gain region at 20q11.2-q12, 13q (21 cases, 34%) with a minimum gain region at 13q22, and 3q (19 cases, 31%) were commonly observed. The regions most frequently lost included: 19p (23 cases, 37%), 17p (21 cases, 33%), and 1p (14 cases, 23%). High copy number gain (DNA sequence amplification) was detected in 6 cases. Amplification of 8q23-q24.2 and 20q11.2-q12 were observed in 3 cases. Gain of 20q and loss of 19p were confirmed by fluorescence in situ hybridization using corresponding bacterial artificial chromosomes (BAC) clones from those regions. The gain and loss of chromosomal regions identified in this study provide candidate regions involved in gastric tumorigenesis. Copyright (C) 2000 Elsevier Science Inc.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationCancer Genetics And Cytogenetics, 2000, v. 123 n. 1, p. 27-34 [How to Cite?]
DOI: http://dx.doi.org/10.1016/S0165-4608(00)00306-X
dc.identifier.doihttp://dx.doi.org/10.1016/S0165-4608(00)00306-X
dc.identifier.epage34
dc.identifier.hkuros61902
dc.identifier.isiWOS:000165915800002
dc.identifier.issn0165-4608
2011 Impact Factor: 1.389
2011 SCImago Journal Rankings: 0.162
dc.identifier.issue1
dc.identifier.openurl
dc.identifier.pmid11120330
dc.identifier.scopuseid_2-s2.0-0033663660
dc.identifier.spage27
dc.identifier.urihttp://hdl.handle.net/10722/72028
dc.identifier.volume123
dc.languageeng
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergene
dc.publisher.placeUnited States
dc.relation.ispartofCancer Genetics and Cytogenetics
dc.relation.referencesReferences in Scopus
dc.rightsCancer Genetics and Cytogenetics. Copyright © Elsevier Inc.
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshChromosome Aberrations
dc.subject.meshDNA, Neoplasm - genetics
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshIn Situ Hybridization, Fluorescence
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshNucleic Acid Hybridization - methods
dc.subject.meshStomach Neoplasms - genetics - pathology
dc.titleRecurrent chromosome changes in 62 primary gastric carcinomas detected by comparative genomic hybridization
dc.typeArticle
Author Affiliations
  1. Jilin University
  2. Harbin Medical University
  3. National Human Genome Research Institute
  4. The University of Hong Kong
  5. Sun Yat Sen University of Medical Sciences