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Article: Recurrent chromosome changes in 62 primary gastric carcinomas detected by comparative genomic hybridization

TitleRecurrent chromosome changes in 62 primary gastric carcinomas detected by comparative genomic hybridization
Authors
Issue Date2000
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergene
Citation
Cancer Genetics And Cytogenetics, 2000, v. 123 n. 1, p. 27-34 How to Cite?
Abstract
Comparative genomic hybridization (CGH) has been applied to detect recurrent chromosome alterations in 62 primary gastric carcinomas. Several nonrandom chromosomal changes, including gains of 8q (31 cases, 50%), 20q (29 cases, 47%) with a minimum gain region at 20q11.2-q12, 13q (21 cases, 34%) with a minimum gain region at 13q22, and 3q (19 cases, 31%) were commonly observed. The regions most frequently lost included: 19p (23 cases, 37%), 17p (21 cases, 33%), and 1p (14 cases, 23%). High copy number gain (DNA sequence amplification) was detected in 6 cases. Amplification of 8q23-q24.2 and 20q11.2-q12 were observed in 3 cases. Gain of 20q and loss of 19p were confirmed by fluorescence in situ hybridization using corresponding bacterial artificial chromosomes (BAC) clones from those regions. The gain and loss of chromosomal regions identified in this study provide candidate regions involved in gastric tumorigenesis. Copyright (C) 2000 Elsevier Science Inc.
Persistent Identifierhttp://hdl.handle.net/10722/72028
ISSN
ISI Accession Number ID
References

 

Author Affiliations
  1. Jilin University
  2. Harbin Medical University
  3. National Human Genome Research Institute
  4. The University of Hong Kong
  5. Sun Yat Sen University of Medical Sciences
DC FieldValueLanguage
dc.contributor.authorGuan, XYen_HK
dc.contributor.authorFu, SBen_HK
dc.contributor.authorXia, JCen_HK
dc.contributor.authorFang, Yen_HK
dc.contributor.authorSham, JSTen_HK
dc.contributor.authorDu, BDen_HK
dc.contributor.authorZhou, Hen_HK
dc.contributor.authorLu, Sen_HK
dc.contributor.authorWang, BQen_HK
dc.contributor.authorLin, YZen_HK
dc.contributor.authorLiang, Qen_HK
dc.contributor.authorLi, XMen_HK
dc.contributor.authorDu, Ben_HK
dc.contributor.authorNing, XMen_HK
dc.contributor.authorDu, JRen_HK
dc.contributor.authorLi, Pen_HK
dc.contributor.authorTrent, JMen_HK
dc.date.accessioned2010-09-06T06:37:38Z-
dc.date.available2010-09-06T06:37:38Z-
dc.date.issued2000en_HK
dc.identifier.citationCancer Genetics And Cytogenetics, 2000, v. 123 n. 1, p. 27-34en_HK
dc.identifier.issn0165-4608en_HK
dc.identifier.urihttp://hdl.handle.net/10722/72028-
dc.description.abstractComparative genomic hybridization (CGH) has been applied to detect recurrent chromosome alterations in 62 primary gastric carcinomas. Several nonrandom chromosomal changes, including gains of 8q (31 cases, 50%), 20q (29 cases, 47%) with a minimum gain region at 20q11.2-q12, 13q (21 cases, 34%) with a minimum gain region at 13q22, and 3q (19 cases, 31%) were commonly observed. The regions most frequently lost included: 19p (23 cases, 37%), 17p (21 cases, 33%), and 1p (14 cases, 23%). High copy number gain (DNA sequence amplification) was detected in 6 cases. Amplification of 8q23-q24.2 and 20q11.2-q12 were observed in 3 cases. Gain of 20q and loss of 19p were confirmed by fluorescence in situ hybridization using corresponding bacterial artificial chromosomes (BAC) clones from those regions. The gain and loss of chromosomal regions identified in this study provide candidate regions involved in gastric tumorigenesis. Copyright (C) 2000 Elsevier Science Inc.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergeneen_HK
dc.relation.ispartofCancer Genetics and Cytogeneticsen_HK
dc.rightsCancer Genetics and Cytogenetics. Copyright © Elsevier Inc.en_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshChromosome Aberrationsen_HK
dc.subject.meshDNA, Neoplasm - geneticsen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshIn Situ Hybridization, Fluorescenceen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshNucleic Acid Hybridization - methodsen_HK
dc.subject.meshStomach Neoplasms - genetics - pathologyen_HK
dc.titleRecurrent chromosome changes in 62 primary gastric carcinomas detected by comparative genomic hybridizationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0165-4608&volume=123&spage=27&epage=34&date=2000&atitle=Recurrent+chromosome+changes+in+62+primary+gastric+carcinomas+detected+by+comparative+genomic+hybridizationen_HK
dc.identifier.emailGuan, XY:xyguan@hkucc.hku.hken_HK
dc.identifier.authorityGuan, XY=rp00454en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0165-4608(00)00306-Xen_HK
dc.identifier.pmid11120330en_HK
dc.identifier.scopuseid_2-s2.0-0033663660en_HK
dc.identifier.hkuros61902en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033663660&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume123en_HK
dc.identifier.issue1en_HK
dc.identifier.spage27en_HK
dc.identifier.epage34en_HK
dc.identifier.isiWOS:000165915800002-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridGuan, XY=7201463221en_HK
dc.identifier.scopusauthoridFu, SB=7402732199en_HK
dc.identifier.scopusauthoridXia, JC=7402327355en_HK
dc.identifier.scopusauthoridFang, Y=7403457405en_HK
dc.identifier.scopusauthoridSham, JST=7101655565en_HK
dc.identifier.scopusauthoridDu, BD=8367049400en_HK
dc.identifier.scopusauthoridZhou, H=38062649800en_HK
dc.identifier.scopusauthoridLu, S=55017214200en_HK
dc.identifier.scopusauthoridWang, BQ=9043707000en_HK
dc.identifier.scopusauthoridLin, YZ=15738306600en_HK
dc.identifier.scopusauthoridLiang, Q=7102360486en_HK
dc.identifier.scopusauthoridLi, XM=26642975000en_HK
dc.identifier.scopusauthoridDu, B=7102831596en_HK
dc.identifier.scopusauthoridNing, XM=8717179600en_HK
dc.identifier.scopusauthoridDu, JR=7402574906en_HK
dc.identifier.scopusauthoridLi, P=7404774183en_HK
dc.identifier.scopusauthoridTrent, JM=7201692482en_HK

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