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Article: Recurrent chromosome changes in 62 primary gastric carcinomas detected by comparative genomic hybridization
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TitleRecurrent chromosome changes in 62 primary gastric carcinomas detected by comparative genomic hybridization
 
AuthorsGuan, XY4
Fu, SB2
Xia, JC2
Fang, Y5
Sham, JST4
Du, BD1
Zhou, H3
Lu, S2
Wang, BQ2
Lin, YZ5
Liang, Q5
Li, XM1
Du, B1
Ning, XM2
Du, JR
Li, P2
Trent, JM3
 
Issue Date2000
 
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergene
 
CitationCancer Genetics And Cytogenetics, 2000, v. 123 n. 1, p. 27-34 [How to Cite?]
DOI: http://dx.doi.org/10.1016/S0165-4608(00)00306-X
 
AbstractComparative genomic hybridization (CGH) has been applied to detect recurrent chromosome alterations in 62 primary gastric carcinomas. Several nonrandom chromosomal changes, including gains of 8q (31 cases, 50%), 20q (29 cases, 47%) with a minimum gain region at 20q11.2-q12, 13q (21 cases, 34%) with a minimum gain region at 13q22, and 3q (19 cases, 31%) were commonly observed. The regions most frequently lost included: 19p (23 cases, 37%), 17p (21 cases, 33%), and 1p (14 cases, 23%). High copy number gain (DNA sequence amplification) was detected in 6 cases. Amplification of 8q23-q24.2 and 20q11.2-q12 were observed in 3 cases. Gain of 20q and loss of 19p were confirmed by fluorescence in situ hybridization using corresponding bacterial artificial chromosomes (BAC) clones from those regions. The gain and loss of chromosomal regions identified in this study provide candidate regions involved in gastric tumorigenesis. Copyright (C) 2000 Elsevier Science Inc.
 
ISSN0165-4608
 
DOIhttp://dx.doi.org/10.1016/S0165-4608(00)00306-X
 
ISI Accession Number IDWOS:000165915800002
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorGuan, XY
 
dc.contributor.authorFu, SB
 
dc.contributor.authorXia, JC
 
dc.contributor.authorFang, Y
 
dc.contributor.authorSham, JST
 
dc.contributor.authorDu, BD
 
dc.contributor.authorZhou, H
 
dc.contributor.authorLu, S
 
dc.contributor.authorWang, BQ
 
dc.contributor.authorLin, YZ
 
dc.contributor.authorLiang, Q
 
dc.contributor.authorLi, XM
 
dc.contributor.authorDu, B
 
dc.contributor.authorNing, XM
 
dc.contributor.authorDu, JR
 
dc.contributor.authorLi, P
 
dc.contributor.authorTrent, JM
 
dc.date.accessioned2010-09-06T06:37:38Z
 
dc.date.available2010-09-06T06:37:38Z
 
dc.date.issued2000
 
dc.description.abstractComparative genomic hybridization (CGH) has been applied to detect recurrent chromosome alterations in 62 primary gastric carcinomas. Several nonrandom chromosomal changes, including gains of 8q (31 cases, 50%), 20q (29 cases, 47%) with a minimum gain region at 20q11.2-q12, 13q (21 cases, 34%) with a minimum gain region at 13q22, and 3q (19 cases, 31%) were commonly observed. The regions most frequently lost included: 19p (23 cases, 37%), 17p (21 cases, 33%), and 1p (14 cases, 23%). High copy number gain (DNA sequence amplification) was detected in 6 cases. Amplification of 8q23-q24.2 and 20q11.2-q12 were observed in 3 cases. Gain of 20q and loss of 19p were confirmed by fluorescence in situ hybridization using corresponding bacterial artificial chromosomes (BAC) clones from those regions. The gain and loss of chromosomal regions identified in this study provide candidate regions involved in gastric tumorigenesis. Copyright (C) 2000 Elsevier Science Inc.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationCancer Genetics And Cytogenetics, 2000, v. 123 n. 1, p. 27-34 [How to Cite?]
DOI: http://dx.doi.org/10.1016/S0165-4608(00)00306-X
 
dc.identifier.doihttp://dx.doi.org/10.1016/S0165-4608(00)00306-X
 
dc.identifier.epage34
 
dc.identifier.hkuros61902
 
dc.identifier.isiWOS:000165915800002
 
dc.identifier.issn0165-4608
 
dc.identifier.issue1
 
dc.identifier.openurl
 
dc.identifier.pmid11120330
 
dc.identifier.scopuseid_2-s2.0-0033663660
 
dc.identifier.spage27
 
dc.identifier.urihttp://hdl.handle.net/10722/72028
 
dc.identifier.volume123
 
dc.languageeng
 
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergene
 
dc.publisher.placeUnited States
 
dc.relation.ispartofCancer Genetics and Cytogenetics
 
dc.relation.referencesReferences in Scopus
 
dc.rightsCancer Genetics and Cytogenetics. Copyright © Elsevier Inc.
 
dc.subject.meshAdult
 
dc.subject.meshAged
 
dc.subject.meshChromosome Aberrations
 
dc.subject.meshDNA, Neoplasm - genetics
 
dc.subject.meshFemale
 
dc.subject.meshHumans
 
dc.subject.meshIn Situ Hybridization, Fluorescence
 
dc.subject.meshMale
 
dc.subject.meshMiddle Aged
 
dc.subject.meshNucleic Acid Hybridization - methods
 
dc.subject.meshStomach Neoplasms - genetics - pathology
 
dc.titleRecurrent chromosome changes in 62 primary gastric carcinomas detected by comparative genomic hybridization
 
dc.typeArticle
 
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<contributor.author>Du, BD</contributor.author>
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Author Affiliations
  1. Jilin University
  2. Harbin Medical University
  3. National Human Genome Research Institute
  4. The University of Hong Kong
  5. Sun Yat Sen University of Medical Sciences