File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Amplification and overexpression of epidermal growth factor receptor gene in glioblastomas of Chinese patients correlates with patient's age but not with tumor's clinicopathological pathway

TitleAmplification and overexpression of epidermal growth factor receptor gene in glioblastomas of Chinese patients correlates with patient's age but not with tumor's clinicopathological pathway
Authors
Issue Date2005
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00401/index.htm
Citation
Acta Neuropathologica, 2005, v. 110 n. 5, p. 481-489 How to Cite?
AbstractIt is believed that there are two distinct pathological pathways leading to the development of human glioblastomas (GBM) in Caucasian populations. Primary (de novo) GBM most often occurs in older individuals, and is characterized by the overexpression/amplification of epidermal growth factor receptor gene (EGFR), whereas secondary GBM, which progresses from a low-grade astrocytoma, often affects younger individuals and frequently contains the TP53 mutation. We and others have previously found that the age of onset of GBM in Chinese patients tends to be younger than that in Caucasian patients. To identify whether GBMs from Chinese patients share this common pattern of genetic alterations, expression levels of EGFR and TP53 and TP53 mutation were analyzed in 56 randomly selected Chinese GBMs (30 primary and 26 secondary), including 47 adult-onset and 9 pediatric GBMs. Consistent with other studies, overexpression/mutation of TP53 and aneuploid DNA content were more frequently detected in secondary GBMs of Chinese adult patients. In contrast to that observed in Caucasian patients, no significant difference was observed in the age distribution and the frequency of EGFR overexpression/amplification between primary and secondary GBMs in adult Chinese patients. Furthermore, the overexpression of EGFR was much higher in late-onset (age >45 years) GBMs (73%) than that in both early-onset (age 18-45 years) (17%) and pediatric (age <18 years) GBMs (11%), suggesting that overexpression of EGFR in Chinese GBMs may be associated closely with the patients age but not with the tumors' pathological pathway. © Springer-Verlag 2005.
Persistent Identifierhttp://hdl.handle.net/10722/72027
ISSN
2015 Impact Factor: 11.36
2015 SCImago Journal Rankings: 6.610
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorXie, Den_HK
dc.contributor.authorZeng, YXen_HK
dc.contributor.authorWang, HJen_HK
dc.contributor.authorTai, LSen_HK
dc.contributor.authorWen, JMen_HK
dc.contributor.authorTao, Yen_HK
dc.contributor.authorMa, NFen_HK
dc.contributor.authorHu, Len_HK
dc.contributor.authorSham, JSTen_HK
dc.contributor.authorGuan, XYen_HK
dc.date.accessioned2010-09-06T06:37:38Z-
dc.date.available2010-09-06T06:37:38Z-
dc.date.issued2005en_HK
dc.identifier.citationActa Neuropathologica, 2005, v. 110 n. 5, p. 481-489en_HK
dc.identifier.issn0001-6322en_HK
dc.identifier.urihttp://hdl.handle.net/10722/72027-
dc.description.abstractIt is believed that there are two distinct pathological pathways leading to the development of human glioblastomas (GBM) in Caucasian populations. Primary (de novo) GBM most often occurs in older individuals, and is characterized by the overexpression/amplification of epidermal growth factor receptor gene (EGFR), whereas secondary GBM, which progresses from a low-grade astrocytoma, often affects younger individuals and frequently contains the TP53 mutation. We and others have previously found that the age of onset of GBM in Chinese patients tends to be younger than that in Caucasian patients. To identify whether GBMs from Chinese patients share this common pattern of genetic alterations, expression levels of EGFR and TP53 and TP53 mutation were analyzed in 56 randomly selected Chinese GBMs (30 primary and 26 secondary), including 47 adult-onset and 9 pediatric GBMs. Consistent with other studies, overexpression/mutation of TP53 and aneuploid DNA content were more frequently detected in secondary GBMs of Chinese adult patients. In contrast to that observed in Caucasian patients, no significant difference was observed in the age distribution and the frequency of EGFR overexpression/amplification between primary and secondary GBMs in adult Chinese patients. Furthermore, the overexpression of EGFR was much higher in late-onset (age >45 years) GBMs (73%) than that in both early-onset (age 18-45 years) (17%) and pediatric (age <18 years) GBMs (11%), suggesting that overexpression of EGFR in Chinese GBMs may be associated closely with the patients age but not with the tumors' pathological pathway. © Springer-Verlag 2005.en_HK
dc.languageengen_HK
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00401/index.htmen_HK
dc.relation.ispartofActa Neuropathologicaen_HK
dc.subject.meshAdolescenten_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshAging - geneticsen_HK
dc.subject.meshAsian Continental Ancestry Group - geneticsen_HK
dc.subject.meshBrain Neoplasms - chemistry - genetics - physiopathologyen_HK
dc.subject.meshChilden_HK
dc.subject.meshChinaen_HK
dc.subject.meshDNA, Neoplasm - analysis - geneticsen_HK
dc.subject.meshEuropean Continental Ancestry Group - geneticsen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGene Amplificationen_HK
dc.subject.meshGene Expression Regulation, Neoplasticen_HK
dc.subject.meshGenes, p53en_HK
dc.subject.meshGlioblastoma - chemistry - genetics - physiopathologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshImmunohistochemistryen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshMutationen_HK
dc.subject.meshPloidiesen_HK
dc.subject.meshReceptor, Epidermal Growth Factor - analysis - geneticsen_HK
dc.subject.meshTumor Suppressor Protein p53 - analysis - genetics - physiologyen_HK
dc.titleAmplification and overexpression of epidermal growth factor receptor gene in glioblastomas of Chinese patients correlates with patient's age but not with tumor's clinicopathological pathwayen_HK
dc.typeArticleen_HK
dc.identifier.emailGuan, XY:xyguan@hkucc.hku.hken_HK
dc.identifier.authorityGuan, XY=rp00454en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s00401-005-1072-yen_HK
dc.identifier.pmid16151725-
dc.identifier.scopuseid_2-s2.0-27944458430en_HK
dc.identifier.hkuros115335en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-27944458430&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume110en_HK
dc.identifier.issue5en_HK
dc.identifier.spage481en_HK
dc.identifier.epage489en_HK
dc.identifier.isiWOS:000233469300006-
dc.publisher.placeGermanyen_HK
dc.identifier.scopusauthoridXie, D=35070710200en_HK
dc.identifier.scopusauthoridZeng, YX=7402981579en_HK
dc.identifier.scopusauthoridWang, HJ=8941461500en_HK
dc.identifier.scopusauthoridTai, LS=7004457333en_HK
dc.identifier.scopusauthoridWen, JM=7402701931en_HK
dc.identifier.scopusauthoridTao, Y=36121574400en_HK
dc.identifier.scopusauthoridMa, NF=35731661400en_HK
dc.identifier.scopusauthoridHu, L=34770075600en_HK
dc.identifier.scopusauthoridSham, JST=24472255400en_HK
dc.identifier.scopusauthoridGuan, XY=7201463221en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats