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Article: Light-induced autofluorescence spectroscopy for detection of nasopharyngeal carcinoma in vivo

TitleLight-induced autofluorescence spectroscopy for detection of nasopharyngeal carcinoma in vivo
Authors
KeywordsEndoscopy
Fluorescence spectroscopy
Principal component analysis
Issue Date2002
PublisherConsultants Bureau. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0021-9037
Citation
Applied Spectroscopy, 2002, v. 56 n. 10, p. 1361-1367 How to Cite?
AbstractAutofluorescence spectral signals were measured in vivo from 85 nasopharyngeal carcinoma lesions and 131 normal tissue sites of 59 subjects during routine nasal endoscopy. Diagnostic algorithms based on principal component analysis and the ratio of the spectral signals between multiple-wavelength bands were developed for classifying the autofluorescence spectra. Performances of the algorithms were evaluated using the cross-validation method. The principal component analysis based algorithms using information from the entire fluorescence spectrum can differentiate nasopharyngeal carcinoma lesions from normal tissue with 95% sensitivity and 93% specificity. With 94% sensitivity, the specificities of multiple-wavelength ratio algorithms are about 83%. The results demonstrate that light-induced autofluorescence endoscopy with principal component analysis algorithms can provide accurate diagnostic information for the detection of nasopharyngeal carcinoma in vivo and may be potentially used in clinical practice combined with the routine white-light endoscopy procedure.
Persistent Identifierhttp://hdl.handle.net/10722/72019
ISSN
2015 Impact Factor: 1.798
2015 SCImago Journal Rankings: 0.668
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChang, Hen_HK
dc.contributor.authorQu, JYen_HK
dc.contributor.authorYuen, Pen_HK
dc.contributor.authorSham, Jen_HK
dc.contributor.authorKwong, Den_HK
dc.contributor.authorWei, WIen_HK
dc.date.accessioned2010-09-06T06:37:33Z-
dc.date.available2010-09-06T06:37:33Z-
dc.date.issued2002en_HK
dc.identifier.citationApplied Spectroscopy, 2002, v. 56 n. 10, p. 1361-1367en_HK
dc.identifier.issn0003-7028en_HK
dc.identifier.urihttp://hdl.handle.net/10722/72019-
dc.description.abstractAutofluorescence spectral signals were measured in vivo from 85 nasopharyngeal carcinoma lesions and 131 normal tissue sites of 59 subjects during routine nasal endoscopy. Diagnostic algorithms based on principal component analysis and the ratio of the spectral signals between multiple-wavelength bands were developed for classifying the autofluorescence spectra. Performances of the algorithms were evaluated using the cross-validation method. The principal component analysis based algorithms using information from the entire fluorescence spectrum can differentiate nasopharyngeal carcinoma lesions from normal tissue with 95% sensitivity and 93% specificity. With 94% sensitivity, the specificities of multiple-wavelength ratio algorithms are about 83%. The results demonstrate that light-induced autofluorescence endoscopy with principal component analysis algorithms can provide accurate diagnostic information for the detection of nasopharyngeal carcinoma in vivo and may be potentially used in clinical practice combined with the routine white-light endoscopy procedure.en_HK
dc.languageengen_HK
dc.publisherConsultants Bureau. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0021-9037en_HK
dc.relation.ispartofApplied Spectroscopyen_HK
dc.subjectEndoscopyen_HK
dc.subjectFluorescence spectroscopyen_HK
dc.subjectPrincipal component analysisen_HK
dc.titleLight-induced autofluorescence spectroscopy for detection of nasopharyngeal carcinoma in vivoen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0021-9037&volume=56&spage=1361&epage=1367&date=2002&atitle=Light-induced+autofluorescence+spectroscopy+for+detection+of+nasopharyngeal+carcinoma+in+vivoen_HK
dc.identifier.emailKwong, D: dlwkwong@hku.hken_HK
dc.identifier.emailWei, WI: hrmswwi@hku.hken_HK
dc.identifier.authorityKwong, D=rp00414en_HK
dc.identifier.authorityWei, WI=rp00323en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1366/000370202760355343en_HK
dc.identifier.scopuseid_2-s2.0-0036801301en_HK
dc.identifier.hkuros77435en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036801301&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume56en_HK
dc.identifier.issue10en_HK
dc.identifier.spage1361en_HK
dc.identifier.epage1367en_HK
dc.identifier.isiWOS:000178667000018-
dc.identifier.scopusauthoridChang, H=7407523707en_HK
dc.identifier.scopusauthoridQu, JY=7201534954en_HK
dc.identifier.scopusauthoridYuen, P=7103124007en_HK
dc.identifier.scopusauthoridSham, J=24472255400en_HK
dc.identifier.scopusauthoridKwong, D=15744231600en_HK
dc.identifier.scopusauthoridWei, WI=7403321552en_HK

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