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Article: Recurrent genetic alterations in 26 colorectal carcinomas and 21 adenomas from Chinese patients

TitleRecurrent genetic alterations in 26 colorectal carcinomas and 21 adenomas from Chinese patients
Authors
Issue Date2003
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergene
Citation
Cancer Genetics And Cytogenetics, 2003, v. 144 n. 2, p. 112-118 How to Cite?
AbstractColorectal cancer (CRC) is one of the most common malignancies worldwide. The incidence of CRC in the Chinese population has increased dramatically during the last two decades; however, nonrandom chromosomal alterations in Chinese patients have not been described. In the present study, comparative genomic hybridization (CGH) was applied to detect recurrent chromosome alterations in 26 primary colorectal carcinomas and 21 colorectal adenomas from Chinese patients. In CRC, several recurrent chromosomal changes were found, including gains of 8q (14/26 cases, 54%), 20q (54%), 3q (50%), 13q (50%), 5p (46%), 7p (42%), 7q (42%), and 12p (38%) and losses of 18q (65%) and 17p (42%). From comparison with previous CGH studies, the frequent gains of 3q and 12p might be distinctive occurrences in Chinese patients. The distribution of frequently found chromosomal alterations in different locations was studied. The gain of 20q was more frequently found in colon cancer (P<0.01) and the gain of 12p was more frequently found in rectal cancer. Chromosomal alterations were found in 19/21 of adenomas; the most frequent chromosomal alteration was the loss of 18q (9/21 cases, 43%). These recurrent alterations provide several starting points for the isolation of candidate oncogenes and tumor suppressor genes. © 2003 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/72012
ISSN
2012 Impact Factor: 1.929
2013 SCImago Journal Rankings: 0.872
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHe, QJen_HK
dc.contributor.authorZeng, WFen_HK
dc.contributor.authorSham, JSTen_HK
dc.contributor.authorXie, Den_HK
dc.contributor.authorYang, XWen_HK
dc.contributor.authorLin, HLen_HK
dc.contributor.authorZhan, WHen_HK
dc.contributor.authorLin, Fen_HK
dc.contributor.authorZeng, SDen_HK
dc.contributor.authorNie, Den_HK
dc.contributor.authorMa, LFen_HK
dc.contributor.authorLi, CJen_HK
dc.contributor.authorLu, Sen_HK
dc.contributor.authorGuan, XYen_HK
dc.date.accessioned2010-09-06T06:37:28Z-
dc.date.available2010-09-06T06:37:28Z-
dc.date.issued2003en_HK
dc.identifier.citationCancer Genetics And Cytogenetics, 2003, v. 144 n. 2, p. 112-118en_HK
dc.identifier.issn0165-4608en_HK
dc.identifier.urihttp://hdl.handle.net/10722/72012-
dc.description.abstractColorectal cancer (CRC) is one of the most common malignancies worldwide. The incidence of CRC in the Chinese population has increased dramatically during the last two decades; however, nonrandom chromosomal alterations in Chinese patients have not been described. In the present study, comparative genomic hybridization (CGH) was applied to detect recurrent chromosome alterations in 26 primary colorectal carcinomas and 21 colorectal adenomas from Chinese patients. In CRC, several recurrent chromosomal changes were found, including gains of 8q (14/26 cases, 54%), 20q (54%), 3q (50%), 13q (50%), 5p (46%), 7p (42%), 7q (42%), and 12p (38%) and losses of 18q (65%) and 17p (42%). From comparison with previous CGH studies, the frequent gains of 3q and 12p might be distinctive occurrences in Chinese patients. The distribution of frequently found chromosomal alterations in different locations was studied. The gain of 20q was more frequently found in colon cancer (P<0.01) and the gain of 12p was more frequently found in rectal cancer. Chromosomal alterations were found in 19/21 of adenomas; the most frequent chromosomal alteration was the loss of 18q (9/21 cases, 43%). These recurrent alterations provide several starting points for the isolation of candidate oncogenes and tumor suppressor genes. © 2003 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergeneen_HK
dc.relation.ispartofCancer Genetics and Cytogeneticsen_HK
dc.rightsCancer Genetics and Cytogenetics. Copyright © Elsevier Inc.en_HK
dc.subject.meshAdenoma - geneticsen_HK
dc.subject.meshChromosome Aberrationsen_HK
dc.subject.meshColorectal Neoplasms - geneticsen_HK
dc.subject.meshHumansen_HK
dc.subject.meshIn Situ Hybridization, Fluorescenceen_HK
dc.subject.meshNucleic Acid Hybridizationen_HK
dc.titleRecurrent genetic alterations in 26 colorectal carcinomas and 21 adenomas from Chinese patientsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0165-4608&volume=144&spage=112&epage=118&date=2003&atitle=Recurrent+Genetic+Alterations+In+26+Colorectal+Carcinomas+And+21+Adenomas+From+Chinese+Patientsen_HK
dc.identifier.emailGuan, XY:xyguan@hkucc.hku.hken_HK
dc.identifier.authorityGuan, XY=rp00454en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0165-4608(02)00959-7en_HK
dc.identifier.pmid12850373en_HK
dc.identifier.scopuseid_2-s2.0-0038693071en_HK
dc.identifier.hkuros81051en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0038693071&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume144en_HK
dc.identifier.issue2en_HK
dc.identifier.spage112en_HK
dc.identifier.epage118en_HK
dc.identifier.isiWOS:000184245600004-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridHe, QJ=36951265200en_HK
dc.identifier.scopusauthoridZeng, WF=8338623800en_HK
dc.identifier.scopusauthoridSham, JST=7101655565en_HK
dc.identifier.scopusauthoridXie, D=35070710200en_HK
dc.identifier.scopusauthoridYang, XW=7406501932en_HK
dc.identifier.scopusauthoridLin, HL=8950219500en_HK
dc.identifier.scopusauthoridZhan, WH=7102238667en_HK
dc.identifier.scopusauthoridLin, F=26643159400en_HK
dc.identifier.scopusauthoridZeng, SD=7202412587en_HK
dc.identifier.scopusauthoridNie, D=12805735000en_HK
dc.identifier.scopusauthoridMa, LF=7403575137en_HK
dc.identifier.scopusauthoridLi, CJ=7501684769en_HK
dc.identifier.scopusauthoridLu, S=7404228450en_HK
dc.identifier.scopusauthoridGuan, XY=7201463221en_HK

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