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Article: Activating mechanism of transcriptor NF-kappaB regulated by hepatitis B virus X protein in hepatocellular carcinoma

TitleActivating mechanism of transcriptor NF-kappaB regulated by hepatitis B virus X protein in hepatocellular carcinoma
Authors
Issue Date2004
PublisherBaishideng Publishing Group. The Journal's web site is located at http://www.wjgnet.com/1007-9327/index.htm
Citation
World Journal Of Gastroenterology, 2004, v. 10 n. 3, p. 356-360 How to Cite?
AbstractAim: To investigate the mechanism and significance of NF-κB activation regulated by hepatitis B virus X protein (HBx) in hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC). Methods: The expression levels of HBx, p65, IκB-α and ubiquitin were detected by immunohistochemistry in HCC tissue microarrays (TMA) respectively, and IκB-α was detected by Western blot in HCC and corresponding liver tissues. Results: The percentage of informative TMA samples was 98.8% in 186 cases with a total of 367 samples. Compared with corresponding liver tissues (60.0%), the HBx expression was obviously decreased in HBV-associated HCC (47.9%, u=2.24, P<0.05). On the contrary, the expressions of p65 (20.6% vs 45.3%, u=4.85, P<0.01) and ubiquitin (8.9% vs 59.0%, u=9.68, P<0.01 ) were notably elevated in HCC. In addition, IκB-α had a tendency to go up. Importantly, positive relativity was observed between HBx and p65 (χ2=10.26, P<0.01), p65 and IκB-α (χ2=16.86, P<0.01), IκB-α and ubiquitin (χ2=8.90, P<0.01) in HCC, respectively. Conclusion: Both active and non-active forms of NF-κB are increased in HBV-associated HCC. Variant HBx is the major cause of the enhancement of NF-κB activity. The activation always proceeds in nucleus and the proteasome complexes play an important role in the activation.
Persistent Identifierhttp://hdl.handle.net/10722/72011
ISSN
2015 Impact Factor: 2.787
2015 SCImago Journal Rankings: 1.076
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWang, Ten_HK
dc.contributor.authorWang, Yen_HK
dc.contributor.authorWu, MCen_HK
dc.contributor.authorGuan, XYen_HK
dc.contributor.authorYin, ZFen_HK
dc.date.accessioned2010-09-06T06:37:28Z-
dc.date.available2010-09-06T06:37:28Z-
dc.date.issued2004en_HK
dc.identifier.citationWorld Journal Of Gastroenterology, 2004, v. 10 n. 3, p. 356-360en_HK
dc.identifier.issn1007-9327en_HK
dc.identifier.urihttp://hdl.handle.net/10722/72011-
dc.description.abstractAim: To investigate the mechanism and significance of NF-κB activation regulated by hepatitis B virus X protein (HBx) in hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC). Methods: The expression levels of HBx, p65, IκB-α and ubiquitin were detected by immunohistochemistry in HCC tissue microarrays (TMA) respectively, and IκB-α was detected by Western blot in HCC and corresponding liver tissues. Results: The percentage of informative TMA samples was 98.8% in 186 cases with a total of 367 samples. Compared with corresponding liver tissues (60.0%), the HBx expression was obviously decreased in HBV-associated HCC (47.9%, u=2.24, P<0.05). On the contrary, the expressions of p65 (20.6% vs 45.3%, u=4.85, P<0.01) and ubiquitin (8.9% vs 59.0%, u=9.68, P<0.01 ) were notably elevated in HCC. In addition, IκB-α had a tendency to go up. Importantly, positive relativity was observed between HBx and p65 (χ2=10.26, P<0.01), p65 and IκB-α (χ2=16.86, P<0.01), IκB-α and ubiquitin (χ2=8.90, P<0.01) in HCC, respectively. Conclusion: Both active and non-active forms of NF-κB are increased in HBV-associated HCC. Variant HBx is the major cause of the enhancement of NF-κB activity. The activation always proceeds in nucleus and the proteasome complexes play an important role in the activation.en_HK
dc.languageengen_HK
dc.publisherBaishideng Publishing Group. The Journal's web site is located at http://www.wjgnet.com/1007-9327/index.htmen_HK
dc.relation.ispartofWorld Journal of Gastroenterologyen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshCarcinoma, Hepatocellular - metabolismen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLiver Neoplasms - metabolismen_HK
dc.subject.meshNF-kappa B - metabolismen_HK
dc.subject.meshTrans-Activators - metabolismen_HK
dc.titleActivating mechanism of transcriptor NF-kappaB regulated by hepatitis B virus X protein in hepatocellular carcinomaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1007-9327&volume=10&spage=356&epage=360&date=2004&atitle=Activating+mechanism+of+transcriptor+NF-kappaB+regulated+by+hepatitis+B+virus+X+protein+in+hepatocellular+carcinoma.en_HK
dc.identifier.emailGuan, XY:xyguan@hkucc.hku.hken_HK
dc.identifier.authorityGuan, XY=rp00454en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3748/wjg.v10.i3.356-
dc.identifier.pmid14760757-
dc.identifier.scopuseid_2-s2.0-1142299661en_HK
dc.identifier.hkuros96129en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-1142299661&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume10en_HK
dc.identifier.issue3en_HK
dc.identifier.spage356en_HK
dc.identifier.epage360en_HK
dc.identifier.isiWOS:000208223800010-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridWang, T=36079778200en_HK
dc.identifier.scopusauthoridWang, Y=7601486269en_HK
dc.identifier.scopusauthoridWu, MC=7405593399en_HK
dc.identifier.scopusauthoridGuan, XY=7201463221en_HK
dc.identifier.scopusauthoridYin, ZF=7401500200en_HK

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