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Article: Establishment and characterization of human metastatic hepatocellular carcinoma cell line

TitleEstablishment and characterization of human metastatic hepatocellular carcinoma cell line
Authors
Issue Date2002
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergene
Citation
Cancer Genetics And Cytogenetics, 2002, v. 135 n. 1, p. 91-95 How to Cite?
AbstractHepatocellular carcinoma (HCC) is one of the most common malignancies worldwide with a poor prognosis. Recently, we established a HCC cell line from a metastatic HCC tumor. GTG banding analysis was performed and the karyotype showed that this metastatic HCC cell line is a hypertriploid (71-78 chromosomes) with a large marker chromosome containing a long homogeneously staining region (hsr). Comparative genomic hybridization was applied to characterize the chromosomal alterations in this metastatic HCC cell line. The results showed that the hsr was composed of amplified DNA sequences from 11q13. Further characterization of the hsr may lead to the isolation of the putative amplified oncogene at 11q13. Copyright © 2002 Elsevier Science Inc.
Persistent Identifierhttp://hdl.handle.net/10722/72010
ISSN
2012 Impact Factor: 1.929
2013 SCImago Journal Rankings: 0.872
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWen, JMen_HK
dc.contributor.authorHuang, JFen_HK
dc.contributor.authorHu, Len_HK
dc.contributor.authorWang, WSen_HK
dc.contributor.authorZhang, Men_HK
dc.contributor.authorSham, JSTen_HK
dc.contributor.authorXu, JMen_HK
dc.contributor.authorZeng, WFen_HK
dc.contributor.authorXie, Den_HK
dc.contributor.authorLiang, LJen_HK
dc.contributor.authorGuan, XYen_HK
dc.date.accessioned2010-09-06T06:37:27Z-
dc.date.available2010-09-06T06:37:27Z-
dc.date.issued2002en_HK
dc.identifier.citationCancer Genetics And Cytogenetics, 2002, v. 135 n. 1, p. 91-95en_HK
dc.identifier.issn0165-4608en_HK
dc.identifier.urihttp://hdl.handle.net/10722/72010-
dc.description.abstractHepatocellular carcinoma (HCC) is one of the most common malignancies worldwide with a poor prognosis. Recently, we established a HCC cell line from a metastatic HCC tumor. GTG banding analysis was performed and the karyotype showed that this metastatic HCC cell line is a hypertriploid (71-78 chromosomes) with a large marker chromosome containing a long homogeneously staining region (hsr). Comparative genomic hybridization was applied to characterize the chromosomal alterations in this metastatic HCC cell line. The results showed that the hsr was composed of amplified DNA sequences from 11q13. Further characterization of the hsr may lead to the isolation of the putative amplified oncogene at 11q13. Copyright © 2002 Elsevier Science Inc.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergeneen_HK
dc.relation.ispartofCancer Genetics and Cytogeneticsen_HK
dc.rightsCancer Genetics and Cytogenetics. Copyright © Elsevier Inc.en_HK
dc.subject.meshAneuploidyen_HK
dc.subject.meshCarcinoma, Hepatocellular - genetics - pathology - secondaryen_HK
dc.subject.meshChromosome Bandingen_HK
dc.subject.meshChromosomes, Human, Pair 11 - genetics - ultrastructureen_HK
dc.subject.meshGene Amplificationen_HK
dc.subject.meshHumansen_HK
dc.subject.meshImage Processing, Computer-Assisteden_HK
dc.subject.meshKaryotypingen_HK
dc.subject.meshLiver Neoplasms - genetics - pathologyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshNucleic Acid Hybridizationen_HK
dc.subject.meshPortal Veinen_HK
dc.subject.meshTumor Cells, Cultureden_HK
dc.subject.meshVascular Neoplasms - genetics - pathology - secondaryen_HK
dc.titleEstablishment and characterization of human metastatic hepatocellular carcinoma cell lineen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0165-4608&volume=135&spage=91&epage=95&date=2002&atitle=Establishment+and+characterization+of+human+metastatic+hepatocellular+carcinoma+cell+lineen_HK
dc.identifier.emailGuan, XY:xyguan@hkucc.hku.hken_HK
dc.identifier.authorityGuan, XY=rp00454en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0165-4608(01)00636-7en_HK
dc.identifier.pmid12072206-
dc.identifier.scopuseid_2-s2.0-18444404918en_HK
dc.identifier.hkuros72187en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-18444404918&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume135en_HK
dc.identifier.issue1en_HK
dc.identifier.spage91en_HK
dc.identifier.epage95en_HK
dc.identifier.isiWOS:000176418400009-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridWen, JM=7402701931en_HK
dc.identifier.scopusauthoridHuang, JF=7407192439en_HK
dc.identifier.scopusauthoridHu, L=34770075600en_HK
dc.identifier.scopusauthoridWang, WS=36488756900en_HK
dc.identifier.scopusauthoridZhang, M=16302423500en_HK
dc.identifier.scopusauthoridSham, JST=7101655565en_HK
dc.identifier.scopusauthoridXu, JM=7408556725en_HK
dc.identifier.scopusauthoridZeng, WF=8338623800en_HK
dc.identifier.scopusauthoridXie, D=35070710200en_HK
dc.identifier.scopusauthoridLiang, LJ=19933936700en_HK
dc.identifier.scopusauthoridGuan, XY=7201463221en_HK

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