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Article: Mucosal changes of the free jejunal graft in response to radiotherapy

TitleMucosal changes of the free jejunal graft in response to radiotherapy
Authors
Issue Date1998
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/amjsurg
Citation
American Journal Of Surgery, 1998, v. 175 n. 1, p. 44-46 How to Cite?
AbstractBACKGROUND: Microvascular free jejunal transfer was employed for reconstruction of Pharyngeal defect resulting from circumferential resection of the hypopharynx. Postoperative radiotherapy to the neck might affect the graft, but this information was lacking. The mucosal changes of the jejunum in response to radiation were identified in this prospective study. METHODS: Normal jejunal mucosa was obtained at operation, and endoscopic jejunal mucosal biopsies were taken during and at completion of radiotherapy. Endoscopic biopsies were repeated at 1, 3, 6, 12, and 24 months afterwards. All jejunal biopsies were subjected to histologic and scanning electron microscopic (SEM) examinations. Nine patients had a complete set of biopsy while 5 other patients who received no radiotherapy also went through a similar sequence of biopsies as controls. RESULTS: Histologic examination showed mucosal edema and extensive blunting of jejunal villi at the completion of radiotherapy. Increased fibrosis with focal loss of glands was noticed at 3 months after radiotherapy, and this remained throughout the 2- year period. SEM revealed patchy loss of microvilli at completion and at 1 month after radiotherapy, but this feature was not apparent in biopsies taken at 3 months onwards, showing that it was only a transient event. CONCLUSIONS: Transient responses and persistent changes of jejunal mucosa to radiotherapy were identified and characterized. The presence of these mucosal lesions was not associated with any clinically significant adverse effect in the graft up to 2 years postradiotherapy.
Persistent Identifierhttp://hdl.handle.net/10722/72002
ISSN
2015 Impact Factor: 2.403
2015 SCImago Journal Rankings: 1.286
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWei, WIen_HK
dc.contributor.authorLam, LKen_HK
dc.contributor.authorYuen, PWen_HK
dc.contributor.authorKwong, Den_HK
dc.contributor.authorChan, KWen_HK
dc.date.accessioned2010-09-06T06:37:22Z-
dc.date.available2010-09-06T06:37:22Z-
dc.date.issued1998en_HK
dc.identifier.citationAmerican Journal Of Surgery, 1998, v. 175 n. 1, p. 44-46en_HK
dc.identifier.issn0002-9610en_HK
dc.identifier.urihttp://hdl.handle.net/10722/72002-
dc.description.abstractBACKGROUND: Microvascular free jejunal transfer was employed for reconstruction of Pharyngeal defect resulting from circumferential resection of the hypopharynx. Postoperative radiotherapy to the neck might affect the graft, but this information was lacking. The mucosal changes of the jejunum in response to radiation were identified in this prospective study. METHODS: Normal jejunal mucosa was obtained at operation, and endoscopic jejunal mucosal biopsies were taken during and at completion of radiotherapy. Endoscopic biopsies were repeated at 1, 3, 6, 12, and 24 months afterwards. All jejunal biopsies were subjected to histologic and scanning electron microscopic (SEM) examinations. Nine patients had a complete set of biopsy while 5 other patients who received no radiotherapy also went through a similar sequence of biopsies as controls. RESULTS: Histologic examination showed mucosal edema and extensive blunting of jejunal villi at the completion of radiotherapy. Increased fibrosis with focal loss of glands was noticed at 3 months after radiotherapy, and this remained throughout the 2- year period. SEM revealed patchy loss of microvilli at completion and at 1 month after radiotherapy, but this feature was not apparent in biopsies taken at 3 months onwards, showing that it was only a transient event. CONCLUSIONS: Transient responses and persistent changes of jejunal mucosa to radiotherapy were identified and characterized. The presence of these mucosal lesions was not associated with any clinically significant adverse effect in the graft up to 2 years postradiotherapy.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/amjsurgen_HK
dc.relation.ispartofAmerican Journal of Surgeryen_HK
dc.rightsThe American Journal of Surgery. Copyright © Elsevier Inc.en_HK
dc.subject.meshAgeden_HK
dc.subject.meshBiopsyen_HK
dc.subject.meshEndoscopyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshHypopharyngeal Neoplasms - radiotherapy - surgeryen_HK
dc.subject.meshIntestinal Mucosa - pathology - radiation effectsen_HK
dc.subject.meshJejunum - pathology - radiation effects - transplantationen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMicroscopy, Electron, Scanningen_HK
dc.subject.meshMicrovilli - pathology - ultrastructureen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshPharyngectomyen_HK
dc.subject.meshPostoperative Careen_HK
dc.subject.meshProspective Studiesen_HK
dc.subject.meshRadiotherapy Dosageen_HK
dc.subject.meshRadiotherapy, Adjuvanten_HK
dc.subject.meshTime Factorsen_HK
dc.titleMucosal changes of the free jejunal graft in response to radiotherapyen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0002-9610&volume=175&spage=44&epage=46&date=1998&atitle=Mucosal+changes+of+the+free+jejunal+graft+in+response+to+radiotherapyen_HK
dc.identifier.emailWei, WI: hrmswwi@hku.hken_HK
dc.identifier.emailKwong, D: dlwkwong@hku.hken_HK
dc.identifier.emailChan, KW: hrmtckw@hku.hken_HK
dc.identifier.authorityWei, WI=rp00323en_HK
dc.identifier.authorityKwong, D=rp00414en_HK
dc.identifier.authorityChan, KW=rp00330en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0002-9610(97)00230-4en_HK
dc.identifier.pmid9445238-
dc.identifier.scopuseid_2-s2.0-0031974380en_HK
dc.identifier.hkuros31089en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0031974380&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume175en_HK
dc.identifier.issue1en_HK
dc.identifier.spage44en_HK
dc.identifier.epage46en_HK
dc.identifier.isiWOS:000071453700012-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridWei, WI=7403321552en_HK
dc.identifier.scopusauthoridLam, LK=7201984637en_HK
dc.identifier.scopusauthoridYuen, PW=7103124007en_HK
dc.identifier.scopusauthoridKwong, D=15744231600en_HK
dc.identifier.scopusauthoridChan, KW=16444133100en_HK

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