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Article: Differential gene methylation in undifferentiated nasopharyngeal carcinoma.

TitleDifferential gene methylation in undifferentiated nasopharyngeal carcinoma.
Authors
Issue Date2003
PublisherSpandidos Publications. The Journal's web site is located at http://www.spandidos-publications.com/ijo/
Citation
International Journal Of Oncology, 2003, v. 22 n. 4, p. 869-874 How to Cite?
AbstractDifferential gene methylation is observed in a variety of human malignancies. The study of the pattern of methylated genes helps to understand carcinogenesis and to identify potential marker tumor genes for clinical use. The differential methylated genes in undifferentiated nasopharyngeal carcinoma (NPC) of Chinese were studied by methylation-specific polymerase chain reaction (MSP). Methylation status of 11 tumor-associated genes (ARF, caspase-8, CDH1, CDKN2A, CDKN2B, MGMT, MLH1, RASSF1A, THBS1, TP73 and VHL) was studied in 30 primary undifferentiated NPC and paired peripheral blood of 12 patients. The methylation profile of NPC in order of frequency was CDH1 (50%), CDKN2B (50%), THBS1 (50%), RASSF1A (46%), MLH1 (40%), MGMT (28%), CDKN2A (23%), TP73 (20%), caspase-8 (7%), ARF (3%) and VHL (0%). Methylation of at least 1 gene was observed in 93% of primary NPC. Of the 12 patients with at least 1 methylated gene in the primary tumor, all 12 (100%) patients had at least 1 of the methylated gene promoter detectable in their peripheral blood. The results show high frequency of methylation in NPC and the potential of using methylation as peripheral blood tumor marker in screening NPC.
Persistent Identifierhttp://hdl.handle.net/10722/72001
ISSN
2015 Impact Factor: 3.018
2015 SCImago Journal Rankings: 1.270
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWong, TSen_HK
dc.contributor.authorTang, KCen_HK
dc.contributor.authorKwong, DLen_HK
dc.contributor.authorSham, JSen_HK
dc.contributor.authorWei, WIen_HK
dc.contributor.authorKwong, YLen_HK
dc.contributor.authorYuen, APen_HK
dc.date.accessioned2010-09-06T06:37:21Z-
dc.date.available2010-09-06T06:37:21Z-
dc.date.issued2003en_HK
dc.identifier.citationInternational Journal Of Oncology, 2003, v. 22 n. 4, p. 869-874en_HK
dc.identifier.issn1019-6439en_HK
dc.identifier.urihttp://hdl.handle.net/10722/72001-
dc.description.abstractDifferential gene methylation is observed in a variety of human malignancies. The study of the pattern of methylated genes helps to understand carcinogenesis and to identify potential marker tumor genes for clinical use. The differential methylated genes in undifferentiated nasopharyngeal carcinoma (NPC) of Chinese were studied by methylation-specific polymerase chain reaction (MSP). Methylation status of 11 tumor-associated genes (ARF, caspase-8, CDH1, CDKN2A, CDKN2B, MGMT, MLH1, RASSF1A, THBS1, TP73 and VHL) was studied in 30 primary undifferentiated NPC and paired peripheral blood of 12 patients. The methylation profile of NPC in order of frequency was CDH1 (50%), CDKN2B (50%), THBS1 (50%), RASSF1A (46%), MLH1 (40%), MGMT (28%), CDKN2A (23%), TP73 (20%), caspase-8 (7%), ARF (3%) and VHL (0%). Methylation of at least 1 gene was observed in 93% of primary NPC. Of the 12 patients with at least 1 methylated gene in the primary tumor, all 12 (100%) patients had at least 1 of the methylated gene promoter detectable in their peripheral blood. The results show high frequency of methylation in NPC and the potential of using methylation as peripheral blood tumor marker in screening NPC.en_HK
dc.languageengen_HK
dc.publisherSpandidos Publications. The Journal's web site is located at http://www.spandidos-publications.com/ijo/en_HK
dc.relation.ispartofInternational journal of oncologyen_HK
dc.subject.meshCarcinoma - genetics-
dc.subject.meshCell Differentiation-
dc.subject.meshDNA - metabolism-
dc.subject.meshDNA Methylation-
dc.subject.meshNasopharyngeal Neoplasms - genetics-
dc.titleDifferential gene methylation in undifferentiated nasopharyngeal carcinoma.en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1019-6439&volume=22&issue=4&spage=869&epage=874&date=2003&atitle=Differential+gene+methylation+in+undifferentiated+nasopharyngeal+carcinomaen_HK
dc.identifier.emailWong, TS: thiansze@graduate.hku.hken_HK
dc.identifier.emailKwong, DL: dlwkwong@hku.hken_HK
dc.identifier.emailWei, WI: hrmswwi@hku.hken_HK
dc.identifier.emailKwong, YL: ylkwong@hku.hken_HK
dc.identifier.authorityWong, TS=rp00478en_HK
dc.identifier.authorityKwong, DL=rp00414en_HK
dc.identifier.authorityWei, WI=rp00323en_HK
dc.identifier.authorityKwong, YL=rp00358en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid12632081-
dc.identifier.scopuseid_2-s2.0-0642378532en_HK
dc.identifier.hkuros75901en_HK
dc.identifier.volume22en_HK
dc.identifier.issue4en_HK
dc.identifier.spage869en_HK
dc.identifier.epage874en_HK
dc.identifier.isiWOS:000181565800022-
dc.publisher.placeGreeceen_HK
dc.identifier.scopusauthoridWong, TS=7403531328en_HK
dc.identifier.scopusauthoridTang, KC=36742146800en_HK
dc.identifier.scopusauthoridKwong, DL=15744231600en_HK
dc.identifier.scopusauthoridSham, JS=24472255400en_HK
dc.identifier.scopusauthoridWei, WI=7403321552en_HK
dc.identifier.scopusauthoridKwong, YL=7102818954en_HK
dc.identifier.scopusauthoridYuen, AP=7006290111en_HK

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