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Article: Prognostic significance of c-myc and AIB1 amplification in hepatocellular carcinoma: A broad survey using high-throughput tissue microarray

TitlePrognostic significance of c-myc and AIB1 amplification in hepatocellular carcinoma: A broad survey using high-throughput tissue microarray
Authors
Issue Date2002
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/28741
Citation
Cancer, 2002, v. 95 n. 11, p. 2346-2352 How to Cite?
AbstractBACKGROUND. Amplifications of 1q21, c-myc at 8q24.1, and AIB1 at 20q12 are genetic alterations that are detected frequently in hepatocellular carcinoma (HCC). The authors evaluated the association of these amplifications with the prognosis of patients with HCC. METHODS. In the current study, amplification of 1q21, c-myc, and AIB1 was analyzed in 560 specimens from 400 patients with HCC and 20 patients with benign liver lesions using fluorescence in situ hybridization with high-throughput tissue microarray. Differences of amplification patterns were compared between small and large HCC, single nodular and multiple nodular HCC, primary and metastatic HCC, and primary and recurrent HCC. RESULTS. Significant differences between single nodular and multiple nodular HCC were detected in c-myc amplification (12% vs. 38%; P < 0.01) and AIB1 amplification (16% vs. 30%; P < 0.05). More frequent c-myc amplification was detected in metastatic HCC (45%) compared with primary HCC (29%) and in recurrent HCC (60%) compared with primary HCC (38%). Similarly, more frequent AIB1 amplification was observed in metastatic HCC (41%) compared with primary HCC (23%) and in recurrent HCC (60%) compared with primary HCC (29%). However, no significant differences in 1q21 amplification were observed. CONCLUSIONS. The current results strongly suggest that amplifications of the c-myc and AIB1 oncogenes are late genetic alterations in the progression of HCC and are correlated with a poor prognosis. © 2002 American Cancer Society.
Persistent Identifierhttp://hdl.handle.net/10722/71997
ISSN
2015 Impact Factor: 5.649
2015 SCImago Journal Rankings: 3.188
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWang, Yen_HK
dc.contributor.authorWu, MCen_HK
dc.contributor.authorSham, JSTen_HK
dc.contributor.authorZhang, Wen_HK
dc.contributor.authorWu, WQen_HK
dc.contributor.authorGuan, XYen_HK
dc.date.accessioned2010-09-06T06:37:19Z-
dc.date.available2010-09-06T06:37:19Z-
dc.date.issued2002en_HK
dc.identifier.citationCancer, 2002, v. 95 n. 11, p. 2346-2352en_HK
dc.identifier.issn0008-543Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/71997-
dc.description.abstractBACKGROUND. Amplifications of 1q21, c-myc at 8q24.1, and AIB1 at 20q12 are genetic alterations that are detected frequently in hepatocellular carcinoma (HCC). The authors evaluated the association of these amplifications with the prognosis of patients with HCC. METHODS. In the current study, amplification of 1q21, c-myc, and AIB1 was analyzed in 560 specimens from 400 patients with HCC and 20 patients with benign liver lesions using fluorescence in situ hybridization with high-throughput tissue microarray. Differences of amplification patterns were compared between small and large HCC, single nodular and multiple nodular HCC, primary and metastatic HCC, and primary and recurrent HCC. RESULTS. Significant differences between single nodular and multiple nodular HCC were detected in c-myc amplification (12% vs. 38%; P < 0.01) and AIB1 amplification (16% vs. 30%; P < 0.05). More frequent c-myc amplification was detected in metastatic HCC (45%) compared with primary HCC (29%) and in recurrent HCC (60%) compared with primary HCC (38%). Similarly, more frequent AIB1 amplification was observed in metastatic HCC (41%) compared with primary HCC (23%) and in recurrent HCC (60%) compared with primary HCC (29%). However, no significant differences in 1q21 amplification were observed. CONCLUSIONS. The current results strongly suggest that amplifications of the c-myc and AIB1 oncogenes are late genetic alterations in the progression of HCC and are correlated with a poor prognosis. © 2002 American Cancer Society.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/28741en_HK
dc.relation.ispartofCanceren_HK
dc.rightsCancer. Copyright © John Wiley & Sons, Inc.en_HK
dc.subject.meshCarcinoma, Hepatocellular - genetics - pathologyen_HK
dc.subject.meshChromosomes, Human, Pair 1 - geneticsen_HK
dc.subject.meshDNA, Neoplasm - geneticsen_HK
dc.subject.meshDisease Progressionen_HK
dc.subject.meshGene Amplificationen_HK
dc.subject.meshGenes, myc - geneticsen_HK
dc.subject.meshHumansen_HK
dc.subject.meshIn Situ Hybridization, Fluorescenceen_HK
dc.subject.meshLiver Neoplasms - genetics - pathologyen_HK
dc.subject.meshNeoplasm Metastasisen_HK
dc.subject.meshNuclear Receptor Coactivator 3en_HK
dc.subject.meshPrognosisen_HK
dc.subject.meshTranscription Factors - geneticsen_HK
dc.titlePrognostic significance of c-myc and AIB1 amplification in hepatocellular carcinoma: A broad survey using high-throughput tissue microarrayen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0008-543X&volume=95&spage=2346&epage=2352&date=2002&atitle=Prognostic+Significance+Of+c-myc+and+AIB1+Amplification+In+Hepatocellular+Carcinoma:+A+Broad+Survey+Using+High-throughput+Tissue+Microarrayen_HK
dc.identifier.emailGuan, XY:xyguan@hkucc.hku.hken_HK
dc.identifier.authorityGuan, XY=rp00454en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/cncr.10963en_HK
dc.identifier.pmid12436441en_HK
dc.identifier.scopuseid_2-s2.0-0036890030en_HK
dc.identifier.hkuros80990en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036890030&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume95en_HK
dc.identifier.issue11en_HK
dc.identifier.spage2346en_HK
dc.identifier.epage2352en_HK
dc.identifier.isiWOS:000179371400013-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridWang, Y=7601486269en_HK
dc.identifier.scopusauthoridWu, MC=7405593399en_HK
dc.identifier.scopusauthoridSham, JST=7101655565en_HK
dc.identifier.scopusauthoridZhang, W=23109885300en_HK
dc.identifier.scopusauthoridWu, WQ=8720711100en_HK
dc.identifier.scopusauthoridGuan, XY=7201463221en_HK

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