Article: Identification of alpha-actinin 4 and 67 kDa laminin receptor as stage-specific markers in esophageal cancer via proteomic approaches

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TitleIdentification of alpha-actinin 4 and 67 kDa laminin receptor as stage-specific markers in esophageal cancer via proteomic approaches
AuthorsFu, L1
Yan, RQ3
Xie, D2
Hoi, YC1
Sai, MN4
Kwong, DLW1
Li, Y2
Xin, YG1 2
Issue Date2007
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/28741
CitationCancer, 2007, v. 110 n. 12, p. 2672-2681 [How to Cite?]
DOI: http://dx.doi.org/10.1002/cncr.23110
AbstractBACKGROUND. Esophageal squamous cell carcinoma (ESCC) is one of the most common malignancies in the world with a very poor prognosis. The majority of ESCC patients present with advanced metastatic disease upon diagnosis. Therefore, it is important to understand the molecular mechanism in the tumor invasion process and to find new biomarkers for early diagnosis and prognostic evaluation. METHODS. Differentially expressed proteins among different stages of primary ESCCs and their matched surrounding normal tissues were compared by proteomics-based technology. The correlations between interesting proteins and clinical features of ESCC were further investigated by using ESCC tissue microarray (TMA) by immunohistochemical staining. RESULTS. Compared with normal tissues, a total of 18 differentially expressed proteins were identified in ESCC in this study. Among them, expression levels of alpha-actinin 4 (ACTN4) and 67 kDa laminin receptor (67LR) were progressively increased from stage I to III. Clinicopathological correlation using TMA revealed that overexpression of ACTN4 was significantly associated with advanced tumor stage (P = .026) and lymph node metastasis (P = .049), whereas overexpression of 67LR was significantly correlated with advanced tumor stage (P = .019) but not lymph node metastasis. CONCLUSIONS. These findings suggested that overexpression of ACTN4 and 67 LR is associated with ESCC progression and that these biomarkers may potentially be useful to prognostic evaluation, molecular biological classification, and therapeutic targeting. © 2007 American Cancer Society.
ISSN0008-543X
2011 Impact Factor: 4.771
2011 SCImago Journal Rankings: 0.578
DOIhttp://dx.doi.org/10.1002/cncr.23110
ISI Accession Number IDWOS:000251573600010
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorFu, L
dc.contributor.authorYan, RQ
dc.contributor.authorXie, D
dc.contributor.authorHoi, YC
dc.contributor.authorSai, MN
dc.contributor.authorKwong, DLW
dc.contributor.authorLi, Y
dc.contributor.authorXin, YG
dc.date.accessioned2010-09-06T06:37:18Z
dc.date.available2010-09-06T06:37:18Z
dc.date.issued2007
dc.description.abstractBACKGROUND. Esophageal squamous cell carcinoma (ESCC) is one of the most common malignancies in the world with a very poor prognosis. The majority of ESCC patients present with advanced metastatic disease upon diagnosis. Therefore, it is important to understand the molecular mechanism in the tumor invasion process and to find new biomarkers for early diagnosis and prognostic evaluation. METHODS. Differentially expressed proteins among different stages of primary ESCCs and their matched surrounding normal tissues were compared by proteomics-based technology. The correlations between interesting proteins and clinical features of ESCC were further investigated by using ESCC tissue microarray (TMA) by immunohistochemical staining. RESULTS. Compared with normal tissues, a total of 18 differentially expressed proteins were identified in ESCC in this study. Among them, expression levels of alpha-actinin 4 (ACTN4) and 67 kDa laminin receptor (67LR) were progressively increased from stage I to III. Clinicopathological correlation using TMA revealed that overexpression of ACTN4 was significantly associated with advanced tumor stage (P = .026) and lymph node metastasis (P = .049), whereas overexpression of 67LR was significantly correlated with advanced tumor stage (P = .019) but not lymph node metastasis. CONCLUSIONS. These findings suggested that overexpression of ACTN4 and 67 LR is associated with ESCC progression and that these biomarkers may potentially be useful to prognostic evaluation, molecular biological classification, and therapeutic targeting. © 2007 American Cancer Society.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationCancer, 2007, v. 110 n. 12, p. 2672-2681 [How to Cite?]
DOI: http://dx.doi.org/10.1002/cncr.23110
dc.identifier.doihttp://dx.doi.org/10.1002/cncr.23110
dc.identifier.epage2681
dc.identifier.hkuros140329
dc.identifier.isiWOS:000251573600010
dc.identifier.issn0008-543X
2011 Impact Factor: 4.771
2011 SCImago Journal Rankings: 0.578
dc.identifier.issue12
dc.identifier.openurl
dc.identifier.pmid17960614
dc.identifier.scopuseid_2-s2.0-37049026274
dc.identifier.spage2672
dc.identifier.urihttp://hdl.handle.net/10722/71995
dc.identifier.volume110
dc.languageeng
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/28741
dc.publisher.placeUnited States
dc.relation.ispartofCancer
dc.relation.referencesReferences in Scopus
dc.rightsCancer. Copyright © John Wiley & Sons, Inc.
dc.subject.meshActinin - analysis
dc.subject.meshCarcinoma, Squamous Cell - chemistry - pathology
dc.subject.meshEsophageal Neoplasms - chemistry - pathology
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshMicrofilament Proteins - analysis
dc.subject.meshMiddle Aged
dc.subject.meshNeoplasm Metastasis
dc.subject.meshNeoplasm Staging - methods
dc.subject.meshPrognosis
dc.subject.meshProtein Array Analysis
dc.subject.meshProteomics
dc.subject.meshReceptors, Laminin - analysis
dc.subject.meshSpectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
dc.subject.meshTumor Markers, Biological - analysis
dc.titleIdentification of alpha-actinin 4 and 67 kDa laminin receptor as stage-specific markers in esophageal cancer via proteomic approaches
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong
  2. Sun Yat-Sen University
  3. First Affiliated Hospital of Zhengzhou University
  4. Chinese University of Hong Kong