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Article: Identification of alpha-actinin 4 and 67 kDa laminin receptor as stage-specific markers in esophageal cancer via proteomic approaches

TitleIdentification of alpha-actinin 4 and 67 kDa laminin receptor as stage-specific markers in esophageal cancer via proteomic approaches
Authors
Issue Date2007
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/28741
Citation
Cancer, 2007, v. 110 n. 12, p. 2672-2681 How to Cite?
AbstractBACKGROUND. Esophageal squamous cell carcinoma (ESCC) is one of the most common malignancies in the world with a very poor prognosis. The majority of ESCC patients present with advanced metastatic disease upon diagnosis. Therefore, it is important to understand the molecular mechanism in the tumor invasion process and to find new biomarkers for early diagnosis and prognostic evaluation. METHODS. Differentially expressed proteins among different stages of primary ESCCs and their matched surrounding normal tissues were compared by proteomics-based technology. The correlations between interesting proteins and clinical features of ESCC were further investigated by using ESCC tissue microarray (TMA) by immunohistochemical staining. RESULTS. Compared with normal tissues, a total of 18 differentially expressed proteins were identified in ESCC in this study. Among them, expression levels of alpha-actinin 4 (ACTN4) and 67 kDa laminin receptor (67LR) were progressively increased from stage I to III. Clinicopathological correlation using TMA revealed that overexpression of ACTN4 was significantly associated with advanced tumor stage (P = .026) and lymph node metastasis (P = .049), whereas overexpression of 67LR was significantly correlated with advanced tumor stage (P = .019) but not lymph node metastasis. CONCLUSIONS. These findings suggested that overexpression of ACTN4 and 67 LR is associated with ESCC progression and that these biomarkers may potentially be useful to prognostic evaluation, molecular biological classification, and therapeutic targeting. © 2007 American Cancer Society.
Persistent Identifierhttp://hdl.handle.net/10722/71995
ISSN
2015 Impact Factor: 5.649
2015 SCImago Journal Rankings: 3.188
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorFu, Len_HK
dc.contributor.authorYan, RQen_HK
dc.contributor.authorXie, Den_HK
dc.contributor.authorHoi, YCen_HK
dc.contributor.authorSai, MNen_HK
dc.contributor.authorKwong, DLWen_HK
dc.contributor.authorLi, Yen_HK
dc.contributor.authorXin, YGen_HK
dc.date.accessioned2010-09-06T06:37:18Z-
dc.date.available2010-09-06T06:37:18Z-
dc.date.issued2007en_HK
dc.identifier.citationCancer, 2007, v. 110 n. 12, p. 2672-2681en_HK
dc.identifier.issn0008-543Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/71995-
dc.description.abstractBACKGROUND. Esophageal squamous cell carcinoma (ESCC) is one of the most common malignancies in the world with a very poor prognosis. The majority of ESCC patients present with advanced metastatic disease upon diagnosis. Therefore, it is important to understand the molecular mechanism in the tumor invasion process and to find new biomarkers for early diagnosis and prognostic evaluation. METHODS. Differentially expressed proteins among different stages of primary ESCCs and their matched surrounding normal tissues were compared by proteomics-based technology. The correlations between interesting proteins and clinical features of ESCC were further investigated by using ESCC tissue microarray (TMA) by immunohistochemical staining. RESULTS. Compared with normal tissues, a total of 18 differentially expressed proteins were identified in ESCC in this study. Among them, expression levels of alpha-actinin 4 (ACTN4) and 67 kDa laminin receptor (67LR) were progressively increased from stage I to III. Clinicopathological correlation using TMA revealed that overexpression of ACTN4 was significantly associated with advanced tumor stage (P = .026) and lymph node metastasis (P = .049), whereas overexpression of 67LR was significantly correlated with advanced tumor stage (P = .019) but not lymph node metastasis. CONCLUSIONS. These findings suggested that overexpression of ACTN4 and 67 LR is associated with ESCC progression and that these biomarkers may potentially be useful to prognostic evaluation, molecular biological classification, and therapeutic targeting. © 2007 American Cancer Society.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/28741en_HK
dc.relation.ispartofCanceren_HK
dc.rightsCancer. Copyright © John Wiley & Sons, Inc.en_HK
dc.subject.meshActinin - analysisen_HK
dc.subject.meshCarcinoma, Squamous Cell - chemistry - pathologyen_HK
dc.subject.meshEsophageal Neoplasms - chemistry - pathologyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMicrofilament Proteins - analysisen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshNeoplasm Metastasisen_HK
dc.subject.meshNeoplasm Staging - methodsen_HK
dc.subject.meshPrognosisen_HK
dc.subject.meshProtein Array Analysisen_HK
dc.subject.meshProteomicsen_HK
dc.subject.meshReceptors, Laminin - analysisen_HK
dc.subject.meshSpectrometry, Mass, Matrix-Assisted Laser Desorption-Ionizationen_HK
dc.subject.meshTumor Markers, Biological - analysisen_HK
dc.titleIdentification of alpha-actinin 4 and 67 kDa laminin receptor as stage-specific markers in esophageal cancer via proteomic approachesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0008-543X&volume=110&spage=2672&epage=2681&date=2007&atitle=Identification+of+alpha-actinin+4+and+67+kDa+laminin+receptor+as+stage-specific+markers+in+esophageal+cancer+via+proteomic+approaches.en_HK
dc.identifier.emailFu, L:gracefu@graduate.hku.hken_HK
dc.identifier.emailKwong, DLW:dlwkwong@hku.hken_HK
dc.identifier.emailXin, YG:xyguan@hkucc.hku.hken_HK
dc.identifier.authorityFu, L=rp01435en_HK
dc.identifier.authorityKwong, DLW=rp00414en_HK
dc.identifier.authorityXin, YG=rp00454en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/cncr.23110en_HK
dc.identifier.pmid17960614-
dc.identifier.scopuseid_2-s2.0-37049026274en_HK
dc.identifier.hkuros140329en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-37049026274&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume110en_HK
dc.identifier.issue12en_HK
dc.identifier.spage2672en_HK
dc.identifier.epage2681en_HK
dc.identifier.isiWOS:000251573600010-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridFu, L=22979236700en_HK
dc.identifier.scopusauthoridYan, RQ=23062340500en_HK
dc.identifier.scopusauthoridXie, D=35070710200en_HK
dc.identifier.scopusauthoridHoi, YC=35082086500en_HK
dc.identifier.scopusauthoridSai, MN=22035995700en_HK
dc.identifier.scopusauthoridKwong, DLW=15744231600en_HK
dc.identifier.scopusauthoridLi, Y=36078824800en_HK
dc.identifier.scopusauthoridXin, YG=7201463221en_HK

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