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Article: Childhood-onset schizophrenia/autistic disorder and t(1;7) reciprocal translocation: Identification of a BAC contig spanning the translocation breakpoint at 7q21

TitleChildhood-onset schizophrenia/autistic disorder and t(1;7) reciprocal translocation: Identification of a BAC contig spanning the translocation breakpoint at 7q21
Authors
Issue Date2000
PublisherJohn Wiley & Sons, Inc.
Citation
American Journal Of Medical Genetics - Neuropsychiatric Genetics, 2000, v. 96 n. 6, p. 749-753 How to Cite?
AbstractChildhood-onset schizophrenia (COS) is defined by the development of first psychotic symptoms by age 12. While recruiting patients with COS refractory to conventional treatments for a trial of atypical antipsychotic drugs, we discovered a unique case who has a familial t(1;7)(p22;q21) reciprocal translocation and onset of psychosis at age 9. The patient also has symptoms of autistic disorder, which are usually transient before the first psychotic episode among 40-50% of the childhood schizophrenics but has persisted in him even after the remission of psychosis. Cosegregating with the translocation, among the carriers in the family available for the study, are other significant psychopathologies, including alcohol/drug abuse, severe impulsivity, and paranoid personality and language delay. This case may provide a model for understanding the genetic basis of schizophrenia or autism. Here we report the progress toward characterization of genomic organization across the translocation breakpoint at 7q21. The polymorphic markers, D7S630/D7S492 and D7S2410/D7S646, immediately flanking the breakpoint, may be useful for further confirming the genetic linkage for schizophrenia or autism in this region.
Persistent Identifierhttp://hdl.handle.net/10722/71991
ISSN
2003 Impact Factor: -999.999
2009 SCImago Journal Rankings: 1.100
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYan, Wen_HK
dc.contributor.authorGuan, XYen_HK
dc.contributor.authorGreen, EDen_HK
dc.contributor.authorNicolson, Ren_HK
dc.contributor.authorYap, TKen_HK
dc.contributor.authorZhang, Jen_HK
dc.contributor.authorJacobsen, LKen_HK
dc.contributor.authorKrasnewich, DMen_HK
dc.contributor.authorKumra, Sen_HK
dc.contributor.authorLenane, MCen_HK
dc.contributor.authorGochman, Pen_HK
dc.contributor.authorDamschroderWilliams, PJen_HK
dc.contributor.authorEsterling, LEen_HK
dc.contributor.authorLong, RTen_HK
dc.contributor.authorMartin, BMen_HK
dc.contributor.authorSidransky, Een_HK
dc.contributor.authorRapoport, JLen_HK
dc.contributor.authorGinns, EIen_HK
dc.date.accessioned2010-09-06T06:37:15Z-
dc.date.available2010-09-06T06:37:15Z-
dc.date.issued2000en_HK
dc.identifier.citationAmerican Journal Of Medical Genetics - Neuropsychiatric Genetics, 2000, v. 96 n. 6, p. 749-753en_HK
dc.identifier.issn0148-7299en_HK
dc.identifier.urihttp://hdl.handle.net/10722/71991-
dc.description.abstractChildhood-onset schizophrenia (COS) is defined by the development of first psychotic symptoms by age 12. While recruiting patients with COS refractory to conventional treatments for a trial of atypical antipsychotic drugs, we discovered a unique case who has a familial t(1;7)(p22;q21) reciprocal translocation and onset of psychosis at age 9. The patient also has symptoms of autistic disorder, which are usually transient before the first psychotic episode among 40-50% of the childhood schizophrenics but has persisted in him even after the remission of psychosis. Cosegregating with the translocation, among the carriers in the family available for the study, are other significant psychopathologies, including alcohol/drug abuse, severe impulsivity, and paranoid personality and language delay. This case may provide a model for understanding the genetic basis of schizophrenia or autism. Here we report the progress toward characterization of genomic organization across the translocation breakpoint at 7q21. The polymorphic markers, D7S630/D7S492 and D7S2410/D7S646, immediately flanking the breakpoint, may be useful for further confirming the genetic linkage for schizophrenia or autism in this region.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc.en_HK
dc.relation.ispartofAmerican Journal of Medical Genetics - Neuropsychiatric Geneticsen_HK
dc.rightsAmerican Journal of Medical Genetics. Copyright © John Wiley & Sons, Inc.en_HK
dc.subject.meshAutistic Disorder - genetics - pathologyen_HK
dc.subject.meshChilden_HK
dc.subject.meshChromosome Breakage - geneticsen_HK
dc.subject.meshChromosomes, Bacterialen_HK
dc.subject.meshChromosomes, Human, Pair 1 - geneticsen_HK
dc.subject.meshChromosomes, Human, Pair 7 - geneticsen_HK
dc.subject.meshContig Mappingen_HK
dc.subject.meshDNA - geneticsen_HK
dc.subject.meshHumansen_HK
dc.subject.meshIn Situ Hybridization, Fluorescenceen_HK
dc.subject.meshMaleen_HK
dc.subject.meshSchizophrenia - genetics - pathologyen_HK
dc.subject.meshTranslocation, Geneticen_HK
dc.titleChildhood-onset schizophrenia/autistic disorder and t(1;7) reciprocal translocation: Identification of a BAC contig spanning the translocation breakpoint at 7q21en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0148-7299&volume=96&spage=749&epage=753&date=2000&atitle=Childhood-onset+schizophrenia/autistic+disorder+and+t(1;7)+reciprocal+translocation:+identification+of+a+BAC+contig+spanning+the+translocation+breakpoint+at+7q21en_HK
dc.identifier.emailGuan, XY:xyguan@hkucc.hku.hken_HK
dc.identifier.authorityGuan, XY=rp00454en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid11121174-
dc.identifier.scopuseid_2-s2.0-0034606266en_HK
dc.identifier.hkuros72263en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034606266&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume96en_HK
dc.identifier.issue6en_HK
dc.identifier.spage749en_HK
dc.identifier.epage753en_HK
dc.identifier.isiWOS:000165717300010-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridYan, W=7402221404en_HK
dc.identifier.scopusauthoridGuan, XY=7201463221en_HK
dc.identifier.scopusauthoridGreen, ED=7201576916en_HK
dc.identifier.scopusauthoridNicolson, R=7005185987en_HK
dc.identifier.scopusauthoridYap, TK=36979872300en_HK
dc.identifier.scopusauthoridZhang, J=9044574100en_HK
dc.identifier.scopusauthoridJacobsen, LK=16144675600en_HK
dc.identifier.scopusauthoridKrasnewich, DM=16211947300en_HK
dc.identifier.scopusauthoridKumra, S=6603693664en_HK
dc.identifier.scopusauthoridLenane, MC=7004722434en_HK
dc.identifier.scopusauthoridGochman, P=6603437619en_HK
dc.identifier.scopusauthoridDamschroderWilliams, PJ=6506417881en_HK
dc.identifier.scopusauthoridEsterling, LE=6602911986en_HK
dc.identifier.scopusauthoridLong, RT=7401715808en_HK
dc.identifier.scopusauthoridMartin, BM=7402931915en_HK
dc.identifier.scopusauthoridSidransky, E=7005375809en_HK
dc.identifier.scopusauthoridRapoport, JL=7102502816en_HK
dc.identifier.scopusauthoridGinns, EI=7005267996en_HK

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