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Article: Stereotactic radiosurgery as a salvage treatment for locally persistent and recurrent nasopharyngeal carcinoma

TitleStereotactic radiosurgery as a salvage treatment for locally persistent and recurrent nasopharyngeal carcinoma
Authors
KeywordsLinac
Local recurrence
Nasopharyngeal carcinoma
Persistent disease
Radiosurgery
Issue Date1999
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38137
Citation
Head And Neck, 1999, v. 21 n. 7, p. 620-626 How to Cite?
AbstractBackground. The purpose of this work was to study the efficacy of stereotactic radiosurgery as a salvage treatment in patients with locally persistent and recurrent nasopharyngeal carcinoma (NPC). Methods. Between March 1996 and August 1997, 10 patients with locally persistent or recurrent NPC were treated by linac-based stereotactic radiosurgery. Four patients had radiosurgery for persistent disease after a first course of radiotherapy, 3 had radiosurgery as a boost after reirradiation for local recurrence, and 3 had radiosurgery for disease that recurred after reirradiation. The tumor volume ranged from 1.3 to 23.7 cc (median: 5.2). Treatment was prescribed at 80% isodose line and ranged from 12 to 18 Gy (median: 13.4), with a mean tumor surface dose ranged from 10-21 Gy (median: 14). The median clinical followup was 10.5 months (range 8-27), and the median imaging follow-up was 9.5 months (range 6-26). Results. One patient had complete regression of tumor after radiosurgery, five had reduction in tumor size, three had no change, and one had progression of tumor. The overall response rate to radiosurgery was 60% (6/10), with 10% (1/10) developing in-field progression. Excluding patients receiving radiosurgery as a boost treatment after reirradiation, the response rate was 57% (4/7) and none developed in-field progression. Only one patient developed a new cranial neuropathy in the absence of disease progression. Conclusion. In selected patients with locally persistent or recurrent NPC, stereotactic radiosurgery can be considered as a salvage treatment with good short-term local control. The complications appear to be minimal except for treating recurrence in the cavernous sinus. Early results are encouraging although more experience and longer follow-up are still needed to better define the role of radiosurgery in the management of persistent and recurrent NPC.
Persistent Identifierhttp://hdl.handle.net/10722/71987
ISSN
2015 Impact Factor: 2.76
2015 SCImago Journal Rankings: 1.233
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChua, DTTen_HK
dc.contributor.authorSham, JSTen_HK
dc.contributor.authorHung, KNen_HK
dc.contributor.authorKwong, DLWen_HK
dc.contributor.authorKwong, PWKen_HK
dc.contributor.authorLeung, LHTen_HK
dc.date.accessioned2010-09-06T06:37:12Z-
dc.date.available2010-09-06T06:37:12Z-
dc.date.issued1999en_HK
dc.identifier.citationHead And Neck, 1999, v. 21 n. 7, p. 620-626en_HK
dc.identifier.issn1043-3074en_HK
dc.identifier.urihttp://hdl.handle.net/10722/71987-
dc.description.abstractBackground. The purpose of this work was to study the efficacy of stereotactic radiosurgery as a salvage treatment in patients with locally persistent and recurrent nasopharyngeal carcinoma (NPC). Methods. Between March 1996 and August 1997, 10 patients with locally persistent or recurrent NPC were treated by linac-based stereotactic radiosurgery. Four patients had radiosurgery for persistent disease after a first course of radiotherapy, 3 had radiosurgery as a boost after reirradiation for local recurrence, and 3 had radiosurgery for disease that recurred after reirradiation. The tumor volume ranged from 1.3 to 23.7 cc (median: 5.2). Treatment was prescribed at 80% isodose line and ranged from 12 to 18 Gy (median: 13.4), with a mean tumor surface dose ranged from 10-21 Gy (median: 14). The median clinical followup was 10.5 months (range 8-27), and the median imaging follow-up was 9.5 months (range 6-26). Results. One patient had complete regression of tumor after radiosurgery, five had reduction in tumor size, three had no change, and one had progression of tumor. The overall response rate to radiosurgery was 60% (6/10), with 10% (1/10) developing in-field progression. Excluding patients receiving radiosurgery as a boost treatment after reirradiation, the response rate was 57% (4/7) and none developed in-field progression. Only one patient developed a new cranial neuropathy in the absence of disease progression. Conclusion. In selected patients with locally persistent or recurrent NPC, stereotactic radiosurgery can be considered as a salvage treatment with good short-term local control. The complications appear to be minimal except for treating recurrence in the cavernous sinus. Early results are encouraging although more experience and longer follow-up are still needed to better define the role of radiosurgery in the management of persistent and recurrent NPC.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38137en_HK
dc.relation.ispartofHead and Necken_HK
dc.subjectLinacen_HK
dc.subjectLocal recurrenceen_HK
dc.subjectNasopharyngeal carcinomaen_HK
dc.subjectPersistent diseaseen_HK
dc.subjectRadiosurgeryen_HK
dc.subject.meshAdenocarcinoma - diagnosis - mortality - surgeryen_HK
dc.subject.meshAdulten_HK
dc.subject.meshBiopsyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshFollow-Up Studiesen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMagnetic Resonance Imagingen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshNasopharyngeal Neoplasms - diagnosis - mortality - surgeryen_HK
dc.subject.meshNeoplasm Recurrence, Local - diagnosis - mortality - surgeryen_HK
dc.subject.meshRadiosurgery - methodsen_HK
dc.subject.meshRetrospective Studiesen_HK
dc.subject.meshSalvage Therapyen_HK
dc.subject.meshStereotaxic Techniquesen_HK
dc.subject.meshSurvival Rateen_HK
dc.subject.meshTomography, X-Ray Computeden_HK
dc.subject.meshTreatment Outcomeen_HK
dc.titleStereotactic radiosurgery as a salvage treatment for locally persistent and recurrent nasopharyngeal carcinomaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0017-8748&volume=21&spage=620&epage=626&date=1999&atitle=Stereotactic+radiosurgery+as+a+salvage+treatment+for+locally+persistent+and+recurrent+nasopharyngeal+carcinomaen_HK
dc.identifier.emailChua, DTT: dttchua@hkucc.hku.hken_HK
dc.identifier.emailKwong, DLW: dlwkwong@hku.hken_HK
dc.identifier.authorityChua, DTT=rp00415en_HK
dc.identifier.authorityKwong, DLW=rp00414en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/(SICI)1097-0347(199910)21:7<620::AID-HED6>3.0.CO;2-Qen_HK
dc.identifier.pmid10487949-
dc.identifier.scopuseid_2-s2.0-0032819601en_HK
dc.identifier.hkuros47264en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032819601&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume21en_HK
dc.identifier.issue7en_HK
dc.identifier.spage620en_HK
dc.identifier.epage626en_HK
dc.identifier.isiWOS:000082837900006-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridChua, DTT=7006773480en_HK
dc.identifier.scopusauthoridSham, JST=24472255400en_HK
dc.identifier.scopusauthoridHung, KN=7202728375en_HK
dc.identifier.scopusauthoridKwong, DLW=15744231600en_HK
dc.identifier.scopusauthoridKwong, PWK=7006992418en_HK
dc.identifier.scopusauthoridLeung, LHT=7202048113en_HK

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