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Article: Diffusion Tensor Magnetic Resonance Imaging Finding of Discrepant Fractional Anisotropy Between the Frontal and Parietal Lobes After Whole-Brain Irradiation in Childhood Medulloblastoma Survivors: Reflection of Regional White Matter Radiosensitivity?

TitleDiffusion Tensor Magnetic Resonance Imaging Finding of Discrepant Fractional Anisotropy Between the Frontal and Parietal Lobes After Whole-Brain Irradiation in Childhood Medulloblastoma Survivors: Reflection of Regional White Matter Radiosensitivity?
Authors
KeywordsAnisotropy
Children
Cranial irradiation
Diffusion tensor MRI
Medulloblastoma
Issue Date2007
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/ijrobp
Citation
International Journal of Radiation Oncology - Biology - Physics, 2007, v. 69 n. 3, p. 846-851 How to Cite?
AbstractPurpose: To test the hypothesis that fractional anisotropy (FA) is more severely reduced in white matter of the frontal lobe compared with the parietal lobe after receiving the same whole-brain irradiation dose in a cohort of childhood medulloblastoma survivors. Methods and Materials: Twenty-two medulloblastoma survivors (15 male, mean [± SD] age = 12.1 ± 4.6 years) and the same number of control subjects (15 male, aged 12.0 ± 4.2 years) were recruited for diffusion tensor magnetic resonance imaging scans. Using an automated tissue classification method and the Talairach Daemon atlas, FA values of frontal and parietal lobes receiving the same radiation dose, and the ratio between them were quantified and denoted as FFA, PFA, and FA f/p, respectively. The Mann-Whitney U test was used to test for significant differences of FFA, PFA, and FA f/p between medulloblastoma survivors and control subjects. Results: Frontal lobe and parietal lobe white matter FA were found to be significantly less in medulloblastoma survivors compared with control subjects (frontal p = 0.001, parietal p = 0.026). Moreover, these differences were found to be discrepant, with the frontal lobe having a significantly larger difference in FA compared with the parietal lobe. The FA f/p of control and medulloblastoma survivors was 1.110 and 1.082, respectively (p = 0.029). Conclusion: Discrepant FA changes after the same irradiation dose suggest radiosensitivity of the frontal lobe white matter compared with the parietal lobe. Special efforts to address the potentially vulnerable frontal lobe after treatment with whole-brain radiation may be needed so as to balance disease control and treatment-related morbidity. © 2007 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/71981
ISSN
2015 Impact Factor: 4.495
2015 SCImago Journal Rankings: 2.274
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorQiu, Den_HK
dc.contributor.authorKwong, DLWen_HK
dc.contributor.authorChan, GCFen_HK
dc.contributor.authorLeung, LHTen_HK
dc.contributor.authorKhong, PLen_HK
dc.date.accessioned2010-09-06T06:37:08Z-
dc.date.available2010-09-06T06:37:08Z-
dc.date.issued2007en_HK
dc.identifier.citationInternational Journal of Radiation Oncology - Biology - Physics, 2007, v. 69 n. 3, p. 846-851en_HK
dc.identifier.issn0360-3016en_HK
dc.identifier.urihttp://hdl.handle.net/10722/71981-
dc.description.abstractPurpose: To test the hypothesis that fractional anisotropy (FA) is more severely reduced in white matter of the frontal lobe compared with the parietal lobe after receiving the same whole-brain irradiation dose in a cohort of childhood medulloblastoma survivors. Methods and Materials: Twenty-two medulloblastoma survivors (15 male, mean [± SD] age = 12.1 ± 4.6 years) and the same number of control subjects (15 male, aged 12.0 ± 4.2 years) were recruited for diffusion tensor magnetic resonance imaging scans. Using an automated tissue classification method and the Talairach Daemon atlas, FA values of frontal and parietal lobes receiving the same radiation dose, and the ratio between them were quantified and denoted as FFA, PFA, and FA f/p, respectively. The Mann-Whitney U test was used to test for significant differences of FFA, PFA, and FA f/p between medulloblastoma survivors and control subjects. Results: Frontal lobe and parietal lobe white matter FA were found to be significantly less in medulloblastoma survivors compared with control subjects (frontal p = 0.001, parietal p = 0.026). Moreover, these differences were found to be discrepant, with the frontal lobe having a significantly larger difference in FA compared with the parietal lobe. The FA f/p of control and medulloblastoma survivors was 1.110 and 1.082, respectively (p = 0.029). Conclusion: Discrepant FA changes after the same irradiation dose suggest radiosensitivity of the frontal lobe white matter compared with the parietal lobe. Special efforts to address the potentially vulnerable frontal lobe after treatment with whole-brain radiation may be needed so as to balance disease control and treatment-related morbidity. © 2007 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/ijrobpen_HK
dc.relation.ispartofInternational Journal of Radiation Oncology - Biology - Physicsen_HK
dc.rightsInternational Journal of Radiation: Oncology - Biology - Physics. Copyright © Elsevier Inc.en_HK
dc.subjectAnisotropyen_HK
dc.subjectChildrenen_HK
dc.subjectCranial irradiationen_HK
dc.subjectDiffusion tensor MRIen_HK
dc.subjectMedulloblastomaen_HK
dc.subject.meshAdolescenten_HK
dc.subject.meshAnisotropyen_HK
dc.subject.meshCase-Control Studiesen_HK
dc.subject.meshCerebellar Neoplasms - pathology - radiotherapyen_HK
dc.subject.meshChilden_HK
dc.subject.meshCranial Irradiation - adverse effects - methodsen_HK
dc.subject.meshCross-Sectional Studiesen_HK
dc.subject.meshDiffusion Magnetic Resonance Imagingen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshFrontal Lobe - pathology - radiation effectsen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMedulloblastoma - pathology - radiotherapyen_HK
dc.subject.meshParietal Lobe - pathology - radiation effectsen_HK
dc.subject.meshRadiation Toleranceen_HK
dc.subject.meshStatistics, Nonparametricen_HK
dc.subject.meshSurvivorsen_HK
dc.titleDiffusion Tensor Magnetic Resonance Imaging Finding of Discrepant Fractional Anisotropy Between the Frontal and Parietal Lobes After Whole-Brain Irradiation in Childhood Medulloblastoma Survivors: Reflection of Regional White Matter Radiosensitivity?en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0360-3016&volume=69&issue=3&spage=846&epage=51&date=2007&atitle=Diffusion+tensor+magnetic+resonance+imaging+finding+of+discrepant+fractional+anisotropy+between+the+frontal+and+parietal+lobes+after+whole-brain+irradiation+in+childhood+medulloblastoma+survivors:+reflection+of+regional+white+matter+radiosensitivity?en_HK
dc.identifier.emailKwong, DLW:dlwkwong@hku.hken_HK
dc.identifier.emailChan, GCF:gcfchan@hkucc.hku.hken_HK
dc.identifier.emailKhong, PL:plkhong@hkucc.hku.hken_HK
dc.identifier.authorityKwong, DLW=rp00414en_HK
dc.identifier.authorityChan, GCF=rp00431en_HK
dc.identifier.authorityKhong, PL=rp00467en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.ijrobp.2007.04.041en_HK
dc.identifier.pmid17544593-
dc.identifier.scopuseid_2-s2.0-34548681188en_HK
dc.identifier.hkuros151999en_HK
dc.identifier.hkuros128335-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34548681188&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume69en_HK
dc.identifier.issue3en_HK
dc.identifier.spage846en_HK
dc.identifier.epage851en_HK
dc.identifier.isiWOS:000249943000028-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridQiu, D=12778150600en_HK
dc.identifier.scopusauthoridKwong, DLW=15744231600en_HK
dc.identifier.scopusauthoridChan, GCF=16160154400en_HK
dc.identifier.scopusauthoridLeung, LHT=7202048113en_HK
dc.identifier.scopusauthoridKhong, PL=7006693233en_HK

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