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Article: Overexpression of YKL-40 is an independent prognostic marker in gastric cancer

TitleOverexpression of YKL-40 is an independent prognostic marker in gastric cancer
Authors
KeywordsGastric carcinoma
Prognostic marker
Tissue microarray
YKL-40
Issue Date2009
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/humpath
Citation
Human Pathology, 2009, v. 40 n. 12, p. 1790-1797 How to Cite?
AbstractYKL-40 is a growth factor for connective tissue cells and a migration factor for endothelial cells. Elevated serum level of YKL-40 has been associated with poor prognosis in many cancers. However, the status of YKL-40 expression and its clinical/prognostic significance in gastric cancer are unclear. In this study, the expression of YKL-40 was studied by immunohistochemistry in gastric cancer tissue microarray containing 172 primary gastric cancer cases and 70 adjacent nonneoplastic mucosa specimens. The correlations between YKL-40 expression and clinicopathologic features, as well as activation of PI3K/Akt pathways were addressed. Expression of YKL-40 was significantly higher in gastric cancer tissues than that in adjacent nonneoplastic tissues. Overexpression YKL-40 was found in 28.4% of gastric cancers and was significantly associated with tumor invasion (P = .007) and lymph node metastasis (P = .009). For survival study, overexpression of YKL-40 was significantly associated with worse outcome (P = .001). When known clinical variables were added to a multivariate analysis, TNM stage, tumor size, and overexpression of YKL-40 emerged as independent prognostic factors. Further study indicated that the oncogenic function of YKL-40 might be through the activation of Akt pathway. These results suggest that overexpression of YKL-40 is correlated with the aggressive behavior of tumor cells, which could be used as an independent molecular marker for the predicting poor prognosis of patients with gastric cancer. © 2009 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/71980
ISSN
2015 Impact Factor: 2.791
2015 SCImago Journal Rankings: 1.363
ISI Accession Number ID
Funding AgencyGrant Number
Sun Yat-sen University85000-3171311
National Natural Science Foundation of China30700805
Guang Dong Natural Science Foundation07117381
5001776
Funding Information:

This work was supported by Sun Yat-sen University "Hundred Talents Program" (85000-3171311), National Natural Science Foundation of China (30700805), Key project of Guang Dong Natural Science Foundation (07117381) and Guang Dong Natural Science Foundation. (5001776). We thank Li-Feng Lu for assistance in survival analysis.

References

 

DC FieldValueLanguage
dc.contributor.authorBi, Jen_HK
dc.contributor.authorLau, SHen_HK
dc.contributor.authorLv, ZLen_HK
dc.contributor.authorXie, Den_HK
dc.contributor.authorLi, Wen_HK
dc.contributor.authorLai, YRen_HK
dc.contributor.authorZhong, JMen_HK
dc.contributor.authorWu, Hqen_HK
dc.contributor.authorSu, Qen_HK
dc.contributor.authorHe, Ylen_HK
dc.contributor.authorZhan, WHen_HK
dc.contributor.authorWen, JMen_HK
dc.contributor.authorGuan, XYen_HK
dc.date.accessioned2010-09-06T06:37:08Z-
dc.date.available2010-09-06T06:37:08Z-
dc.date.issued2009en_HK
dc.identifier.citationHuman Pathology, 2009, v. 40 n. 12, p. 1790-1797en_HK
dc.identifier.issn0046-8177en_HK
dc.identifier.urihttp://hdl.handle.net/10722/71980-
dc.description.abstractYKL-40 is a growth factor for connective tissue cells and a migration factor for endothelial cells. Elevated serum level of YKL-40 has been associated with poor prognosis in many cancers. However, the status of YKL-40 expression and its clinical/prognostic significance in gastric cancer are unclear. In this study, the expression of YKL-40 was studied by immunohistochemistry in gastric cancer tissue microarray containing 172 primary gastric cancer cases and 70 adjacent nonneoplastic mucosa specimens. The correlations between YKL-40 expression and clinicopathologic features, as well as activation of PI3K/Akt pathways were addressed. Expression of YKL-40 was significantly higher in gastric cancer tissues than that in adjacent nonneoplastic tissues. Overexpression YKL-40 was found in 28.4% of gastric cancers and was significantly associated with tumor invasion (P = .007) and lymph node metastasis (P = .009). For survival study, overexpression of YKL-40 was significantly associated with worse outcome (P = .001). When known clinical variables were added to a multivariate analysis, TNM stage, tumor size, and overexpression of YKL-40 emerged as independent prognostic factors. Further study indicated that the oncogenic function of YKL-40 might be through the activation of Akt pathway. These results suggest that overexpression of YKL-40 is correlated with the aggressive behavior of tumor cells, which could be used as an independent molecular marker for the predicting poor prognosis of patients with gastric cancer. © 2009 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/humpathen_HK
dc.relation.ispartofHuman Pathologyen_HK
dc.subjectGastric carcinomaen_HK
dc.subjectPrognostic markeren_HK
dc.subjectTissue microarrayen_HK
dc.subjectYKL-40en_HK
dc.subject.meshGlycoproteins - biosynthesis-
dc.subject.meshLectins - biosynthesis-
dc.subject.meshStomach Neoplasms - metabolism - mortality - pathology-
dc.subject.meshTumor Markers, Biological - analysis-
dc.subject.meshImmunohistochemistry-
dc.titleOverexpression of YKL-40 is an independent prognostic marker in gastric canceren_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0046-8177&volume=40&issue=12&spage=1790&epage=1797&date=2009&atitle=Overexpression+of+YKL-40+is+an+independent+prognostic+marker+in+gastric+canceren_HK
dc.identifier.emailGuan, XY:xyguan@hkucc.hku.hken_HK
dc.identifier.authorityGuan, XY=rp00454en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.humpath.2009.07.005en_HK
dc.identifier.pmid19765801-
dc.identifier.scopuseid_2-s2.0-70449094665en_HK
dc.identifier.hkuros169984en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-70449094665&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume40en_HK
dc.identifier.issue12en_HK
dc.identifier.spage1790en_HK
dc.identifier.epage1797en_HK
dc.identifier.isiWOS:000272102200017-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridBi, J=7103093361en_HK
dc.identifier.scopusauthoridLau, SH=7401596190en_HK
dc.identifier.scopusauthoridLv, ZL=25522189000en_HK
dc.identifier.scopusauthoridXie, D=35070710200en_HK
dc.identifier.scopusauthoridLi, W=26643110300en_HK
dc.identifier.scopusauthoridLai, YR=7401512408en_HK
dc.identifier.scopusauthoridZhong, JM=35605296800en_HK
dc.identifier.scopusauthoridWu, Hq=35313054600en_HK
dc.identifier.scopusauthoridSu, Q=35312793600en_HK
dc.identifier.scopusauthoridHe, Yl=7404941584en_HK
dc.identifier.scopusauthoridZhan, WH=7102238667en_HK
dc.identifier.scopusauthoridWen, JM=7402701931en_HK
dc.identifier.scopusauthoridGuan, XY=7201463221en_HK

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