File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Oncogenic role of eIF-5A2 in the development of ovarian cancer

TitleOncogenic role of eIF-5A2 in the development of ovarian cancer
Authors
Issue Date2004
PublisherAmerican Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/
Citation
Cancer Research, 2004, v. 64 n. 12, p. 4197-4200 How to Cite?
AbstractAmplification of 3q26 is one of the most frequent chromosomal alterations in many solid tumors, including ovarian, lung, esophageal, prostate, breast, and nasopharyngeal cancers. A candidate oncogene to eukaryotic initiation factor 5A2 (eIF-5A2), a member of eukaryotic initiation factor 5A subfamily, has been isolated from a frequently amplified region at 3q26.2. In this work, the tumorigenic ability of eIF-5A2 was demonstrated by anchorage-independent growth in soft agar and tumor formation in nude mice. Furthermore, antisense DNA against eIF-5A2 could inhibit cell growth in ovarian cancer cell line UACC-1598 with amplification of eIF-5A2 in form of double minutes. Cell growth rate in UACC-1598 was also inhibited when the expression level of EIF-5A2 was decreased by the reduction of the copy number of double minutes. The correlation of EIF-5A2 overexpression and clinical features of ovarian cancer was investigated using tissue microarray, and the result showed that eIF-5A2 overexpression was significantly associated with the advanced stage of ovarian cancer. These findings suggest that eIF-5A2 plays important roles in ovarian pathogenesis.
Persistent Identifierhttp://hdl.handle.net/10722/71979
ISSN
2015 Impact Factor: 8.556
2015 SCImago Journal Rankings: 5.372
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorGuan, XYen_HK
dc.contributor.authorFung, JMWen_HK
dc.contributor.authorMa, NFen_HK
dc.contributor.authorLau, SHen_HK
dc.contributor.authorTai, LSen_HK
dc.contributor.authorXie, Den_HK
dc.contributor.authorZhang, Yen_HK
dc.contributor.authorHu, Len_HK
dc.contributor.authorWu, QLen_HK
dc.contributor.authorFang, Yen_HK
dc.contributor.authorSham, JSTen_HK
dc.date.accessioned2010-09-06T06:37:07Z-
dc.date.available2010-09-06T06:37:07Z-
dc.date.issued2004en_HK
dc.identifier.citationCancer Research, 2004, v. 64 n. 12, p. 4197-4200en_HK
dc.identifier.issn0008-5472en_HK
dc.identifier.urihttp://hdl.handle.net/10722/71979-
dc.description.abstractAmplification of 3q26 is one of the most frequent chromosomal alterations in many solid tumors, including ovarian, lung, esophageal, prostate, breast, and nasopharyngeal cancers. A candidate oncogene to eukaryotic initiation factor 5A2 (eIF-5A2), a member of eukaryotic initiation factor 5A subfamily, has been isolated from a frequently amplified region at 3q26.2. In this work, the tumorigenic ability of eIF-5A2 was demonstrated by anchorage-independent growth in soft agar and tumor formation in nude mice. Furthermore, antisense DNA against eIF-5A2 could inhibit cell growth in ovarian cancer cell line UACC-1598 with amplification of eIF-5A2 in form of double minutes. Cell growth rate in UACC-1598 was also inhibited when the expression level of EIF-5A2 was decreased by the reduction of the copy number of double minutes. The correlation of EIF-5A2 overexpression and clinical features of ovarian cancer was investigated using tissue microarray, and the result showed that eIF-5A2 overexpression was significantly associated with the advanced stage of ovarian cancer. These findings suggest that eIF-5A2 plays important roles in ovarian pathogenesis.en_HK
dc.languageengen_HK
dc.publisherAmerican Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/en_HK
dc.relation.ispartofCancer Researchen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshCell Division - geneticsen_HK
dc.subject.meshCell Line, Tumoren_HK
dc.subject.meshChromosome Mappingen_HK
dc.subject.meshDNA, Antisense - geneticsen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMiceen_HK
dc.subject.meshNIH 3T3 Cellsen_HK
dc.subject.meshOvarian Neoplasms - genetics - metabolism - pathologyen_HK
dc.subject.meshPeptide Initiation Factors - antagonists & inhibitors - biosynthesis - geneticsen_HK
dc.subject.meshSignal Transduction - geneticsen_HK
dc.titleOncogenic role of eIF-5A2 in the development of ovarian canceren_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0008-5472&volume=64&spage=4197&epage=4200&date=2004&atitle=Oncogenic+role+of+eIF-5A2+in+the+development+of+ovarian+cancer.en_HK
dc.identifier.emailGuan, XY:xyguan@hkucc.hku.hken_HK
dc.identifier.authorityGuan, XY=rp00454en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1158/0008-5472.CAN-03-3747en_HK
dc.identifier.pmid15205331en_HK
dc.identifier.scopuseid_2-s2.0-3042616347en_HK
dc.identifier.hkuros96145en_HK
dc.identifier.hkuros115334-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-3042616347&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume64en_HK
dc.identifier.issue12en_HK
dc.identifier.spage4197en_HK
dc.identifier.epage4200en_HK
dc.identifier.isiWOS:000222077900021-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridGuan, XY=7201463221en_HK
dc.identifier.scopusauthoridFung, JMW=23469161200en_HK
dc.identifier.scopusauthoridMa, NF=35731661400en_HK
dc.identifier.scopusauthoridLau, SH=7401596190en_HK
dc.identifier.scopusauthoridTai, LS=7004457333en_HK
dc.identifier.scopusauthoridXie, D=35070710200en_HK
dc.identifier.scopusauthoridZhang, Y=15841225400en_HK
dc.identifier.scopusauthoridHu, L=34770075600en_HK
dc.identifier.scopusauthoridWu, QL=7404602639en_HK
dc.identifier.scopusauthoridFang, Y=7403457405en_HK
dc.identifier.scopusauthoridSham, JST=7101655565en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats