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Article: Staging of nasopharyngeal carcinoma: Suggestions for improving the current UICC/AJCC Staging System

TitleStaging of nasopharyngeal carcinoma: Suggestions for improving the current UICC/AJCC Staging System
Authors
KeywordsNasopharyngeal carcinoma
Prognostication
TNM staging
Issue Date2004
PublisherWB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/clon
Citation
Clinical Oncology, 2004, v. 16 n. 4, p. 269-276 How to Cite?
AbstractAims: To evaluate the current UICC/AJCC Staging System for nasopharyngeal carcinoma and to search for ways of improving the system. Materials and methods: This is a retrospective analysis of 2687 consecutive patients treated in five public centres in Hong Kong during the period 1996-2000. All patients were staged by computed tomography, magnetic resonance imaging, or both. The prognostic significance of the current stage assignment on various aspects of tumour control was evaluated. Results: T-category, N-category and stage-group were all significant prognostic factors for major end points (P<0.01). However, the distinction of prognosis between Stage I and II was insignificant (5-year cancer-specific survival being 92% vs 95%; P=0.13). Multivariate analyses (corrected for age and sex) revealed lack of significance between T2a and T1 in hazards of local and distant failures, N3a and N2 in distant failure and subgroups of T1-2N0 in cancer-specific deaths. Corresponding down-staging of T2a to T1, N3a to N2, and subgroup T2N0 to stage I, resulted in more even and orderly increase in the hazard ratio of cancer-specific deaths (from 1 for stage I to 1.98 for II, 3.5 for III, 6.08 for IVA and 8.62 for IVB), better hazard consistency among subgroups of the same stage and more balanced stage distribution. Conclusions: The current UICC/AJCC staging System could be further improved by the modifications suggested; validation of the current proposal by external data is urgently awaited. © 2004 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/71977
ISSN
2015 Impact Factor: 3.212
2015 SCImago Journal Rankings: 1.194
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLee, AWMen_HK
dc.contributor.authorAu, JSKen_HK
dc.contributor.authorTeo, PMLen_HK
dc.contributor.authorLeung, TWen_HK
dc.contributor.authorChua, DTTen_HK
dc.contributor.authorSze, WMen_HK
dc.contributor.authorZee, BCYen_HK
dc.contributor.authorLaw, SCKen_HK
dc.contributor.authorLeung, SFen_HK
dc.contributor.authorTung, SYen_HK
dc.contributor.authorKwong, DLWen_HK
dc.contributor.authorLau, WHen_HK
dc.date.accessioned2010-09-06T06:37:06Z-
dc.date.available2010-09-06T06:37:06Z-
dc.date.issued2004en_HK
dc.identifier.citationClinical Oncology, 2004, v. 16 n. 4, p. 269-276en_HK
dc.identifier.issn0936-6555en_HK
dc.identifier.urihttp://hdl.handle.net/10722/71977-
dc.description.abstractAims: To evaluate the current UICC/AJCC Staging System for nasopharyngeal carcinoma and to search for ways of improving the system. Materials and methods: This is a retrospective analysis of 2687 consecutive patients treated in five public centres in Hong Kong during the period 1996-2000. All patients were staged by computed tomography, magnetic resonance imaging, or both. The prognostic significance of the current stage assignment on various aspects of tumour control was evaluated. Results: T-category, N-category and stage-group were all significant prognostic factors for major end points (P<0.01). However, the distinction of prognosis between Stage I and II was insignificant (5-year cancer-specific survival being 92% vs 95%; P=0.13). Multivariate analyses (corrected for age and sex) revealed lack of significance between T2a and T1 in hazards of local and distant failures, N3a and N2 in distant failure and subgroups of T1-2N0 in cancer-specific deaths. Corresponding down-staging of T2a to T1, N3a to N2, and subgroup T2N0 to stage I, resulted in more even and orderly increase in the hazard ratio of cancer-specific deaths (from 1 for stage I to 1.98 for II, 3.5 for III, 6.08 for IVA and 8.62 for IVB), better hazard consistency among subgroups of the same stage and more balanced stage distribution. Conclusions: The current UICC/AJCC staging System could be further improved by the modifications suggested; validation of the current proposal by external data is urgently awaited. © 2004 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherWB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/clonen_HK
dc.relation.ispartofClinical Oncologyen_HK
dc.subjectNasopharyngeal carcinomaen_HK
dc.subjectPrognosticationen_HK
dc.subjectTNM stagingen_HK
dc.subject.meshAdolescenten_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshAged, 80 and overen_HK
dc.subject.meshDisease-Free Survivalen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHong Kong - epidemiologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMedical Recordsen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshNasopharyngeal Neoplasms - epidemiology - mortality - pathologyen_HK
dc.subject.meshNeoplasm Stagingen_HK
dc.subject.meshPrognosisen_HK
dc.subject.meshRetrospective Studiesen_HK
dc.subject.meshSurvival Analysisen_HK
dc.titleStaging of nasopharyngeal carcinoma: Suggestions for improving the current UICC/AJCC Staging Systemen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0936-6555&volume=16&spage=269&epage=76&date=2004&atitle=Staging+of+nasopharyngeal+carcinoma:+suggestions+for+improving+the+current+UICC/AJCC+Staging+Systemen_HK
dc.identifier.emailChua, DTT: dttchua@hkucc.hku.hken_HK
dc.identifier.emailKwong, DLW: dlwkwong@hku.hken_HK
dc.identifier.authorityChua, DTT=rp00415en_HK
dc.identifier.authorityKwong, DLW=rp00414en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.clon.2004.01.008en_HK
dc.identifier.pmid15214651-
dc.identifier.scopuseid_2-s2.0-2542519941en_HK
dc.identifier.hkuros90189en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-2542519941&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume16en_HK
dc.identifier.issue4en_HK
dc.identifier.spage269en_HK
dc.identifier.epage276en_HK
dc.identifier.isiWOS:000221629300007-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLee, AWN=14820702400en_HK
dc.identifier.scopusauthoridAu, JSK=7101921203en_HK
dc.identifier.scopusauthoridTeo, PML=7006685066en_HK
dc.identifier.scopusauthoridLeung, TW=7202110934en_HK
dc.identifier.scopusauthoridChua, DTT=7006773480en_HK
dc.identifier.scopusauthoridSze, WM=7003795941en_HK
dc.identifier.scopusauthoridZee, BCY=7006378172en_HK
dc.identifier.scopusauthoridLaw, SCK=7202241299en_HK
dc.identifier.scopusauthoridLeung, SF=7202044876en_HK
dc.identifier.scopusauthoridTung, SY=7102858954en_HK
dc.identifier.scopusauthoridKwong, DLW=15744231600en_HK
dc.identifier.scopusauthoridLau, WH=7402933278en_HK

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