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Article: Pulmonary sequelae of treatment for breast cancer: A prospective study

TitlePulmonary sequelae of treatment for breast cancer: A prospective study
Authors
KeywordsBreast
Cancer
Loco-regional
Radiotherapy effects
Issue Date2001
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/ijrobp
Citation
International Journal of Radiation Oncology - Biology - Physics, 2001, v. 50 n. 2, p. 411-419 How to Cite?
AbstractPurpose: To prospectively study the effects of loco-regional radiotherapy in women with breast cancer. Methods and Materials: Thirty consecutive patients with breast resection underwent clinical, lung function, radiographic, and thoracic high-resolution computed tomography evaluation before and at 1, 3, 6, and 12 months after adjuvant radiotherapy. Chemotherapy was also administered to 15 patients. Results: Nineteen patients reported mild respiratory symptoms at 1 month, which resolved completely at 6 months after radiotherapy. Opacities were present on 80% of chest radiographs and in all patients on high-resolution computed tomography by 3 months. These opacities became compact and persisted on high-resolution computed tomography at 12 months. Lung function indices, including FEV1, FVC, TLC, and DLCO, progressively declined after radiotherapy, and was irreversible at 12 months (p < 0.05). Patients who received chemotherapy did not have significantly different lung function indices compared with their counterparts at all time points (p > 0.05). Conclusions: Our results have shown that adjuvant loco-regional radiotherapy, a common practice in breast cancer treatment, is associated with irreversible reduction in lung function parameters. These changes are accompanied by radiological evidence of persistent lung injury. Further studies should be performed to evaluate the incidence and long-term pulmonary sequelae of current treatment for breast cancer. Copyright © 2001 Elsevier Science Inc.
Persistent Identifierhttp://hdl.handle.net/10722/71976
ISSN
2015 Impact Factor: 4.495
2015 SCImago Journal Rankings: 2.274
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorOoi, GCen_HK
dc.contributor.authorKwong, DLen_HK
dc.contributor.authorHo, JCen_HK
dc.contributor.authorLock, DTen_HK
dc.contributor.authorChan, FLen_HK
dc.contributor.authorLam, WKen_HK
dc.contributor.authorNgan, Hen_HK
dc.contributor.authorAu, Gen_HK
dc.contributor.authorTsang, KWen_HK
dc.date.accessioned2010-09-06T06:37:05Z-
dc.date.available2010-09-06T06:37:05Z-
dc.date.issued2001en_HK
dc.identifier.citationInternational Journal of Radiation Oncology - Biology - Physics, 2001, v. 50 n. 2, p. 411-419en_HK
dc.identifier.issn0360-3016en_HK
dc.identifier.urihttp://hdl.handle.net/10722/71976-
dc.description.abstractPurpose: To prospectively study the effects of loco-regional radiotherapy in women with breast cancer. Methods and Materials: Thirty consecutive patients with breast resection underwent clinical, lung function, radiographic, and thoracic high-resolution computed tomography evaluation before and at 1, 3, 6, and 12 months after adjuvant radiotherapy. Chemotherapy was also administered to 15 patients. Results: Nineteen patients reported mild respiratory symptoms at 1 month, which resolved completely at 6 months after radiotherapy. Opacities were present on 80% of chest radiographs and in all patients on high-resolution computed tomography by 3 months. These opacities became compact and persisted on high-resolution computed tomography at 12 months. Lung function indices, including FEV1, FVC, TLC, and DLCO, progressively declined after radiotherapy, and was irreversible at 12 months (p < 0.05). Patients who received chemotherapy did not have significantly different lung function indices compared with their counterparts at all time points (p > 0.05). Conclusions: Our results have shown that adjuvant loco-regional radiotherapy, a common practice in breast cancer treatment, is associated with irreversible reduction in lung function parameters. These changes are accompanied by radiological evidence of persistent lung injury. Further studies should be performed to evaluate the incidence and long-term pulmonary sequelae of current treatment for breast cancer. Copyright © 2001 Elsevier Science Inc.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/ijrobpen_HK
dc.relation.ispartofInternational Journal of Radiation Oncology - Biology - Physicsen_HK
dc.rightsInternational Journal of Radiation: Oncology - Biology - Physics. Copyright © Elsevier Inc.en_HK
dc.subjectBreasten_HK
dc.subjectCanceren_HK
dc.subjectLoco-regionalen_HK
dc.subjectRadiotherapy effectsen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshBreast Neoplasms - physiopathology - radiotherapy - surgeryen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshForced Expiratory Flow Rates - radiation effectsen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLongitudinal Studiesen_HK
dc.subject.meshLung - physiopathology - radiation effects - radiographyen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshProspective Studiesen_HK
dc.subject.meshRadiation Injuries - etiology - physiopathologyen_HK
dc.subject.meshRadiotherapy, Adjuvanten_HK
dc.subject.meshRespiration Disorders - etiology - physiopathologyen_HK
dc.subject.meshTomography, X-Ray Computeden_HK
dc.subject.meshTotal Lung Capacity - radiation effectsen_HK
dc.subject.meshVital Capacity - radiation effectsen_HK
dc.titlePulmonary sequelae of treatment for breast cancer: A prospective studyen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0360-3016&volume=50&issue=2&spage=411&epage=419&date=2001&atitle=Pulmonary+sequelae+of+treatment+for+breast+cancer:+a+prospective+study.en_HK
dc.identifier.emailKwong, DL:dlwkwong@hku.hken_HK
dc.identifier.emailHo, JC:jhocm@hku.hken_HK
dc.identifier.authorityKwong, DL=rp00414en_HK
dc.identifier.authorityHo, JC=rp00258en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0360-3016(01)01438-9en_HK
dc.identifier.pmid11380228-
dc.identifier.scopuseid_2-s2.0-0035371552en_HK
dc.identifier.hkuros61799en_HK
dc.identifier.hkuros68262-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035371552&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume50en_HK
dc.identifier.issue2en_HK
dc.identifier.spage411en_HK
dc.identifier.epage419en_HK
dc.identifier.isiWOS:000168781000016-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridOoi, GC=7006176119en_HK
dc.identifier.scopusauthoridKwong, DL=15744231600en_HK
dc.identifier.scopusauthoridHo, JC=7402649981en_HK
dc.identifier.scopusauthoridLock, DT=7003694952en_HK
dc.identifier.scopusauthoridChan, FL=7202586444en_HK
dc.identifier.scopusauthoridLam, WK=7203021937en_HK
dc.identifier.scopusauthoridNgan, H=7102173824en_HK
dc.identifier.scopusauthoridAu, G=7003748615en_HK
dc.identifier.scopusauthoridTsang, KW=7201555024en_HK

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