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Article: Overexpression of clusterin correlates with tumor progression, metastasis in gastric cancer: A study on tissue microarrays

TitleOverexpression of clusterin correlates with tumor progression, metastasis in gastric cancer: A study on tissue microarrays
Authors
KeywordsClusterin
Gastric carcinoma
Tissue microarray
Issue Date2010
PublisherVydavatel'stvo Slovenskej Akademie Vied Veda. The Journal's web site is located at http://www.neoplasma.sk
Citation
Neoplasma, 2010, v. 57 n. 3, p. 191-197 How to Cite?
AbstractClusterin (CLU) is expressed in a wide variety of human tissues and fluids. Overexpression of cytoplasmic clusterin (sCLU) has been implicated in cancer development and progression. The aim of the present study is to evaluate the association of sCLU overexpression with clinicopathological features of human gastric carcinomas (GC).We constructed a gastric cancer tissue microarray containing 173 primary gastric carcinomas and 70 paired non-neoplastic mucosa specimens. The expression of sCLU was studied by immunohistochemistry. The correlations between sCLU expression and clinicopathological features, p53 abnormality, as well as Ki67 activation were analyzed. Overexpressions of sCLU was detected in 28.5% (n=165) of primary GCs by immunohistochemical staining, but not in non-neoplastic mucosa. Clinical association study found that overexpression of sCLU was significantly correlated with lymph-node metastasis (p < 0.001), tumor invasion (p < 0.001) and TNM stage (p < 0.001). In Kaplan-Meier survival analysis, overexpression of sCLU was significantly correlated with unfavorable survival in advanced GCs (p < 0.03). Furthermore, the association of sCLU with abnormal expression of p53 was ascertained. These results suggested that overexpression of sCLU was involved in the progression of GC and it's oncogenic function might be associated with p53 abnormality. Overexpression of sCLU seems to be related with patient's shorter survival in late stage GC.
Persistent Identifierhttp://hdl.handle.net/10722/71972
ISSN
2015 Impact Factor: 1.961
2015 SCImago Journal Rankings: 0.726
ISI Accession Number ID
Funding AgencyGrant Number
Guang Dong Natural Science Foundation07117381
9451008901002106
06020986
Guang Dong province2009B030801014
Funding Information:

This work was supported by Key project of Guang Dong Natural Science Foundation (07117381), Guang Dong Natural Science Foundation (9451008901002106, 06020986) and Science & Technology Projects of Guang Dong province (2009B030801014).

References

 

DC FieldValueLanguage
dc.contributor.authorBi, Jen_HK
dc.contributor.authorGuo, ALen_HK
dc.contributor.authorLai, YRen_HK
dc.contributor.authorLi, Ben_HK
dc.contributor.authorZhong, JMen_HK
dc.contributor.authorWu, HQen_HK
dc.contributor.authorXie, Zen_HK
dc.contributor.authorHe, YLen_HK
dc.contributor.authorLv, ZLen_HK
dc.contributor.authorLau, SHen_HK
dc.contributor.authorWang, Qen_HK
dc.contributor.authorHuang, XHen_HK
dc.contributor.authorZhang, LJen_HK
dc.contributor.authorWen, JMen_HK
dc.contributor.authorGuan, XYen_HK
dc.date.accessioned2010-09-06T06:37:03Z-
dc.date.available2010-09-06T06:37:03Z-
dc.date.issued2010en_HK
dc.identifier.citationNeoplasma, 2010, v. 57 n. 3, p. 191-197en_HK
dc.identifier.issn0028-2685en_HK
dc.identifier.urihttp://hdl.handle.net/10722/71972-
dc.description.abstractClusterin (CLU) is expressed in a wide variety of human tissues and fluids. Overexpression of cytoplasmic clusterin (sCLU) has been implicated in cancer development and progression. The aim of the present study is to evaluate the association of sCLU overexpression with clinicopathological features of human gastric carcinomas (GC).We constructed a gastric cancer tissue microarray containing 173 primary gastric carcinomas and 70 paired non-neoplastic mucosa specimens. The expression of sCLU was studied by immunohistochemistry. The correlations between sCLU expression and clinicopathological features, p53 abnormality, as well as Ki67 activation were analyzed. Overexpressions of sCLU was detected in 28.5% (n=165) of primary GCs by immunohistochemical staining, but not in non-neoplastic mucosa. Clinical association study found that overexpression of sCLU was significantly correlated with lymph-node metastasis (p < 0.001), tumor invasion (p < 0.001) and TNM stage (p < 0.001). In Kaplan-Meier survival analysis, overexpression of sCLU was significantly correlated with unfavorable survival in advanced GCs (p < 0.03). Furthermore, the association of sCLU with abnormal expression of p53 was ascertained. These results suggested that overexpression of sCLU was involved in the progression of GC and it's oncogenic function might be associated with p53 abnormality. Overexpression of sCLU seems to be related with patient's shorter survival in late stage GC.en_HK
dc.languageengen_HK
dc.publisherVydavatel'stvo Slovenskej Akademie Vied Veda. The Journal's web site is located at http://www.neoplasma.sken_HK
dc.relation.ispartofNeoplasmaen_HK
dc.subjectClusterinen_HK
dc.subjectGastric carcinomaen_HK
dc.subjectTissue microarrayen_HK
dc.subject.meshClusterin - analysis - physiology-
dc.subject.meshStomach Neoplasms - chemistry - mortality - pathology-
dc.subject.meshTissue Array Analysis - methods-
dc.subject.meshCytoplasm/chemistry-
dc.subject.meshNeoplasm Metastasis-
dc.titleOverexpression of clusterin correlates with tumor progression, metastasis in gastric cancer: A study on tissue microarraysen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0028-2685&volume=57&issue=3&spage=191&epage=197&date=2010&atitle=Overexpression+of+clusterin+correlates+with+tumor+progression,+metastasis+in+gastric+cancer:+a+study+on+tissue+microarraysen_HK
dc.identifier.emailGuan, XY:xyguan@hkucc.hku.hken_HK
dc.identifier.authorityGuan, XY=rp00454en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.4149/neo_2010_03_191en_HK
dc.identifier.pmid20353268-
dc.identifier.scopuseid_2-s2.0-77954655294en_HK
dc.identifier.hkuros169644en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77954655294&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume57en_HK
dc.identifier.issue3en_HK
dc.identifier.spage191en_HK
dc.identifier.epage197en_HK
dc.identifier.isiWOS:000277412800001-
dc.publisher.placeSlovakiaen_HK
dc.identifier.scopusauthoridBi, J=7103093361en_HK
dc.identifier.scopusauthoridGuo, AL=12793848000en_HK
dc.identifier.scopusauthoridLai, YR=55052959600en_HK
dc.identifier.scopusauthoridLi, B=55046897900en_HK
dc.identifier.scopusauthoridZhong, JM=55053704000en_HK
dc.identifier.scopusauthoridWu, HQ=55048793900en_HK
dc.identifier.scopusauthoridXie, Z=55055002400en_HK
dc.identifier.scopusauthoridHe, YL=55047050700en_HK
dc.identifier.scopusauthoridLv, ZL=25522189000en_HK
dc.identifier.scopusauthoridLau, SH=55054463300en_HK
dc.identifier.scopusauthoridWang, Q=55049037200en_HK
dc.identifier.scopusauthoridHuang, XH=8057162600en_HK
dc.identifier.scopusauthoridZhang, LJ=55052201200en_HK
dc.identifier.scopusauthoridWen, JM=55054619600en_HK
dc.identifier.scopusauthoridGuan, XY=7201463221en_HK

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