Article: Volumetric analysis of tumor extent in nasopharyngeal carcinoma and correlation with treatment outcome

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TitleVolumetric analysis of tumor extent in nasopharyngeal carcinoma and correlation with treatment outcome
AuthorsChua, DTT
Sham, JST1
Kwong, DLW
Tai, KS
Wu, PM
Lo, M
Yung, A
Choy, D
Leong, L
KeywordsComputed tomography
Local control
Nasopharyngeal carcinoma
Radiotherapy
Tumor volume
Issue Date1997
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/ijrobp
CitationInternational Journal Of Radiation Oncology Biology Physics, 1997, v. 39 n. 3, p. 711-719 [How to Cite?]
DOI: http://dx.doi.org/10.1016/S0360-3016(97)00374-X
AbstractPurpose: To investigate the variability of tumor volume in nasopharyngeal carcinoma using quantitative measurements of tumor hulk derived from computed tomography, and to study the prognostic value of tumor volume in comparison with other variables. Methods and Materials: Two hundred ninety patients with newly diagnosed nasopharyngeal carcinoma were included in the study. The primary tumor volume (PTV) and nodal tumor volume (NTV) were obtained by outlining the tumor contour followed by summation of areas in sequential pretreatment computed tomography axial scans. Total tumor volume (TTV) was obtained by adding the PTV and NTV. All patients had radiotherapy as the primary treatment, 67 patients also received cisplatin- based neoadjuvant chemotheraphy. Results: A large variation in tumor volume was observed, especially in advanced stage disease. The median PTV (cc) in Ho's T1, T2, and T3 disease were: 6.9 (range: 0.9 - 42.7), 18.8 (1.6-127.9), and 52.4 (3.3-166.8). The median TTV (cc) in Ho's stage I to IV disease were: 7.6 (range: 1.3-42.7), 19.8 (3.2-55.7), 40.7 (4.1-222.7), and 51.1 (3.1- 274.7). Patients with a large PTV (>60 cc) were associated with significantly poorer local control (5-year local control rate: 56%) and disease-specific survival (5-year survival rate: 53%). In patients with a small PTV (≤20 cc), there were no significant differences in local control among different T stages. Large NTV (>30 cc) was associated with significantly higher distant failure rate (5-year distant relapse-free survival rate: 54%) and lower disease-specific survival (5-year survival rate: 40%). In multivariate analysis, only PTV was found to be an independent factor in predicting local control. Conclusion: A large variation of tumor volume was present in different T stage disease of nasopharyngeal carcinoma, and PTV represents an independent prognostic factor of local control that appears to be more predictive than Ho's T stage classification.
ISSN0360-3016
2011 Impact Factor: 4.105
2011 SCImago Journal Rankings: 0.402
DOIhttp://dx.doi.org/10.1016/S0360-3016(97)00374-X
ISI Accession Number IDWOS:A1997YA91700027
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorChua, DTT
dc.contributor.authorSham, JST
dc.contributor.authorKwong, DLW
dc.contributor.authorTai, KS
dc.contributor.authorWu, PM
dc.contributor.authorLo, M
dc.contributor.authorYung, A
dc.contributor.authorChoy, D
dc.contributor.authorLeong, L
dc.date.accessioned2010-09-06T06:36:50Z
dc.date.available2010-09-06T06:36:50Z
dc.date.issued1997
dc.description.abstractPurpose: To investigate the variability of tumor volume in nasopharyngeal carcinoma using quantitative measurements of tumor hulk derived from computed tomography, and to study the prognostic value of tumor volume in comparison with other variables. Methods and Materials: Two hundred ninety patients with newly diagnosed nasopharyngeal carcinoma were included in the study. The primary tumor volume (PTV) and nodal tumor volume (NTV) were obtained by outlining the tumor contour followed by summation of areas in sequential pretreatment computed tomography axial scans. Total tumor volume (TTV) was obtained by adding the PTV and NTV. All patients had radiotherapy as the primary treatment, 67 patients also received cisplatin- based neoadjuvant chemotheraphy. Results: A large variation in tumor volume was observed, especially in advanced stage disease. The median PTV (cc) in Ho's T1, T2, and T3 disease were: 6.9 (range: 0.9 - 42.7), 18.8 (1.6-127.9), and 52.4 (3.3-166.8). The median TTV (cc) in Ho's stage I to IV disease were: 7.6 (range: 1.3-42.7), 19.8 (3.2-55.7), 40.7 (4.1-222.7), and 51.1 (3.1- 274.7). Patients with a large PTV (>60 cc) were associated with significantly poorer local control (5-year local control rate: 56%) and disease-specific survival (5-year survival rate: 53%). In patients with a small PTV (≤20 cc), there were no significant differences in local control among different T stages. Large NTV (>30 cc) was associated with significantly higher distant failure rate (5-year distant relapse-free survival rate: 54%) and lower disease-specific survival (5-year survival rate: 40%). In multivariate analysis, only PTV was found to be an independent factor in predicting local control. Conclusion: A large variation of tumor volume was present in different T stage disease of nasopharyngeal carcinoma, and PTV represents an independent prognostic factor of local control that appears to be more predictive than Ho's T stage classification.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationInternational Journal Of Radiation Oncology Biology Physics, 1997, v. 39 n. 3, p. 711-719 [How to Cite?]
DOI: http://dx.doi.org/10.1016/S0360-3016(97)00374-X
dc.identifier.doihttp://dx.doi.org/10.1016/S0360-3016(97)00374-X
dc.identifier.epage719
dc.identifier.hkuros34746
dc.identifier.isiWOS:A1997YA91700027
dc.identifier.issn0360-3016
2011 Impact Factor: 4.105
2011 SCImago Journal Rankings: 0.402
dc.identifier.issue3
dc.identifier.openurl
dc.identifier.pmid9336154
dc.identifier.scopuseid_2-s2.0-0030986414
dc.identifier.spage711
dc.identifier.urihttp://hdl.handle.net/10722/71951
dc.identifier.volume39
dc.languageeng
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/ijrobp
dc.publisher.placeUnited States
dc.relation.ispartofInternational Journal of Radiation Oncology Biology Physics
dc.relation.referencesReferences in Scopus
dc.rightsInternational Journal of Radiation: Oncology - Biology - Physics. Copyright © Elsevier Inc.
dc.subject.meshAdult
dc.subject.meshAnalysis of Variance
dc.subject.meshAntineoplastic Combined Chemotherapy Protocols - therapeutic use
dc.subject.meshCarcinoma - drug therapy - pathology - radiography - radiotherapy
dc.subject.meshChemotherapy, Adjuvant
dc.subject.meshCisplatin - administration & dosage
dc.subject.meshDose Fractionation
dc.subject.meshEpirubicin - administration & dosage
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshNasopharyngeal Neoplasms - drug therapy - pathology - radiography - radiotherapy
dc.subject.meshNeoplasm Staging
dc.subject.meshPrognosis
dc.subject.meshRandomized Controlled Trials as Topic
dc.subject.meshRetrospective Studies
dc.subject.meshTomography, X-Ray Computed
dc.subject.meshTreatment Outcome
dc.subjectComputed tomography
dc.subjectLocal control
dc.subjectNasopharyngeal carcinoma
dc.subjectRadiotherapy
dc.subjectTumor volume
dc.titleVolumetric analysis of tumor extent in nasopharyngeal carcinoma and correlation with treatment outcome
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong