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Article: Volumetric analysis of tumor extent in nasopharyngeal carcinoma and correlation with treatment outcome
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TitleVolumetric analysis of tumor extent in nasopharyngeal carcinoma and correlation with treatment outcome
 
AuthorsChua, DTT
Sham, JST1
Kwong, DLW
Tai, KS
Wu, PM
Lo, M
Yung, A
Choy, D
Leong, L
 
KeywordsComputed tomography
Local control
Nasopharyngeal carcinoma
Radiotherapy
Tumor volume
 
Issue Date1997
 
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/ijrobp
 
CitationInternational Journal Of Radiation Oncology Biology Physics, 1997, v. 39 n. 3, p. 711-719 [How to Cite?]
DOI: http://dx.doi.org/10.1016/S0360-3016(97)00374-X
 
AbstractPurpose: To investigate the variability of tumor volume in nasopharyngeal carcinoma using quantitative measurements of tumor hulk derived from computed tomography, and to study the prognostic value of tumor volume in comparison with other variables. Methods and Materials: Two hundred ninety patients with newly diagnosed nasopharyngeal carcinoma were included in the study. The primary tumor volume (PTV) and nodal tumor volume (NTV) were obtained by outlining the tumor contour followed by summation of areas in sequential pretreatment computed tomography axial scans. Total tumor volume (TTV) was obtained by adding the PTV and NTV. All patients had radiotherapy as the primary treatment, 67 patients also received cisplatin- based neoadjuvant chemotheraphy. Results: A large variation in tumor volume was observed, especially in advanced stage disease. The median PTV (cc) in Ho's T1, T2, and T3 disease were: 6.9 (range: 0.9 - 42.7), 18.8 (1.6-127.9), and 52.4 (3.3-166.8). The median TTV (cc) in Ho's stage I to IV disease were: 7.6 (range: 1.3-42.7), 19.8 (3.2-55.7), 40.7 (4.1-222.7), and 51.1 (3.1- 274.7). Patients with a large PTV (>60 cc) were associated with significantly poorer local control (5-year local control rate: 56%) and disease-specific survival (5-year survival rate: 53%). In patients with a small PTV (≤20 cc), there were no significant differences in local control among different T stages. Large NTV (>30 cc) was associated with significantly higher distant failure rate (5-year distant relapse-free survival rate: 54%) and lower disease-specific survival (5-year survival rate: 40%). In multivariate analysis, only PTV was found to be an independent factor in predicting local control. Conclusion: A large variation of tumor volume was present in different T stage disease of nasopharyngeal carcinoma, and PTV represents an independent prognostic factor of local control that appears to be more predictive than Ho's T stage classification.
 
ISSN0360-3016
2012 Impact Factor: 4.524
2012 SCImago Journal Rankings: 2.237
 
DOIhttp://dx.doi.org/10.1016/S0360-3016(97)00374-X
 
ISI Accession Number IDWOS:A1997YA91700027
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorChua, DTT
 
dc.contributor.authorSham, JST
 
dc.contributor.authorKwong, DLW
 
dc.contributor.authorTai, KS
 
dc.contributor.authorWu, PM
 
dc.contributor.authorLo, M
 
dc.contributor.authorYung, A
 
dc.contributor.authorChoy, D
 
dc.contributor.authorLeong, L
 
dc.date.accessioned2010-09-06T06:36:50Z
 
dc.date.available2010-09-06T06:36:50Z
 
dc.date.issued1997
 
dc.description.abstractPurpose: To investigate the variability of tumor volume in nasopharyngeal carcinoma using quantitative measurements of tumor hulk derived from computed tomography, and to study the prognostic value of tumor volume in comparison with other variables. Methods and Materials: Two hundred ninety patients with newly diagnosed nasopharyngeal carcinoma were included in the study. The primary tumor volume (PTV) and nodal tumor volume (NTV) were obtained by outlining the tumor contour followed by summation of areas in sequential pretreatment computed tomography axial scans. Total tumor volume (TTV) was obtained by adding the PTV and NTV. All patients had radiotherapy as the primary treatment, 67 patients also received cisplatin- based neoadjuvant chemotheraphy. Results: A large variation in tumor volume was observed, especially in advanced stage disease. The median PTV (cc) in Ho's T1, T2, and T3 disease were: 6.9 (range: 0.9 - 42.7), 18.8 (1.6-127.9), and 52.4 (3.3-166.8). The median TTV (cc) in Ho's stage I to IV disease were: 7.6 (range: 1.3-42.7), 19.8 (3.2-55.7), 40.7 (4.1-222.7), and 51.1 (3.1- 274.7). Patients with a large PTV (>60 cc) were associated with significantly poorer local control (5-year local control rate: 56%) and disease-specific survival (5-year survival rate: 53%). In patients with a small PTV (≤20 cc), there were no significant differences in local control among different T stages. Large NTV (>30 cc) was associated with significantly higher distant failure rate (5-year distant relapse-free survival rate: 54%) and lower disease-specific survival (5-year survival rate: 40%). In multivariate analysis, only PTV was found to be an independent factor in predicting local control. Conclusion: A large variation of tumor volume was present in different T stage disease of nasopharyngeal carcinoma, and PTV represents an independent prognostic factor of local control that appears to be more predictive than Ho's T stage classification.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationInternational Journal Of Radiation Oncology Biology Physics, 1997, v. 39 n. 3, p. 711-719 [How to Cite?]
DOI: http://dx.doi.org/10.1016/S0360-3016(97)00374-X
 
dc.identifier.doihttp://dx.doi.org/10.1016/S0360-3016(97)00374-X
 
dc.identifier.epage719
 
dc.identifier.hkuros34746
 
dc.identifier.isiWOS:A1997YA91700027
 
dc.identifier.issn0360-3016
2012 Impact Factor: 4.524
2012 SCImago Journal Rankings: 2.237
 
dc.identifier.issue3
 
dc.identifier.openurl
 
dc.identifier.pmid9336154
 
dc.identifier.scopuseid_2-s2.0-0030986414
 
dc.identifier.spage711
 
dc.identifier.urihttp://hdl.handle.net/10722/71951
 
dc.identifier.volume39
 
dc.languageeng
 
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/ijrobp
 
dc.publisher.placeUnited States
 
dc.relation.ispartofInternational Journal of Radiation Oncology Biology Physics
 
dc.relation.referencesReferences in Scopus
 
dc.rightsInternational Journal of Radiation: Oncology - Biology - Physics. Copyright © Elsevier Inc.
 
dc.subject.meshAdult
 
dc.subject.meshAnalysis of Variance
 
dc.subject.meshAntineoplastic Combined Chemotherapy Protocols - therapeutic use
 
dc.subject.meshCarcinoma - drug therapy - pathology - radiography - radiotherapy
 
dc.subject.meshChemotherapy, Adjuvant
 
dc.subject.meshCisplatin - administration & dosage
 
dc.subject.meshDose Fractionation
 
dc.subject.meshEpirubicin - administration & dosage
 
dc.subject.meshFemale
 
dc.subject.meshHumans
 
dc.subject.meshMale
 
dc.subject.meshMiddle Aged
 
dc.subject.meshNasopharyngeal Neoplasms - drug therapy - pathology - radiography - radiotherapy
 
dc.subject.meshNeoplasm Staging
 
dc.subject.meshPrognosis
 
dc.subject.meshRandomized Controlled Trials as Topic
 
dc.subject.meshRetrospective Studies
 
dc.subject.meshTomography, X-Ray Computed
 
dc.subject.meshTreatment Outcome
 
dc.subjectComputed tomography
 
dc.subjectLocal control
 
dc.subjectNasopharyngeal carcinoma
 
dc.subjectRadiotherapy
 
dc.subjectTumor volume
 
dc.titleVolumetric analysis of tumor extent in nasopharyngeal carcinoma and correlation with treatment outcome
 
dc.typeArticle
 
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<contributor.author>Sham, JST</contributor.author>
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<contributor.author>Wu, PM</contributor.author>
<contributor.author>Lo, M</contributor.author>
<contributor.author>Yung, A</contributor.author>
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Author Affiliations
  1. The University of Hong Kong