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Article: Volumetric analysis of tumor extent in nasopharyngeal carcinoma and correlation with treatment outcome

TitleVolumetric analysis of tumor extent in nasopharyngeal carcinoma and correlation with treatment outcome
Authors
KeywordsComputed tomography
Local control
Nasopharyngeal carcinoma
Radiotherapy
Tumor volume
Issue Date1997
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/ijrobp
Citation
International Journal Of Radiation Oncology Biology Physics, 1997, v. 39 n. 3, p. 711-719 How to Cite?
Abstract
Purpose: To investigate the variability of tumor volume in nasopharyngeal carcinoma using quantitative measurements of tumor hulk derived from computed tomography, and to study the prognostic value of tumor volume in comparison with other variables. Methods and Materials: Two hundred ninety patients with newly diagnosed nasopharyngeal carcinoma were included in the study. The primary tumor volume (PTV) and nodal tumor volume (NTV) were obtained by outlining the tumor contour followed by summation of areas in sequential pretreatment computed tomography axial scans. Total tumor volume (TTV) was obtained by adding the PTV and NTV. All patients had radiotherapy as the primary treatment, 67 patients also received cisplatin- based neoadjuvant chemotheraphy. Results: A large variation in tumor volume was observed, especially in advanced stage disease. The median PTV (cc) in Ho's T1, T2, and T3 disease were: 6.9 (range: 0.9 - 42.7), 18.8 (1.6-127.9), and 52.4 (3.3-166.8). The median TTV (cc) in Ho's stage I to IV disease were: 7.6 (range: 1.3-42.7), 19.8 (3.2-55.7), 40.7 (4.1-222.7), and 51.1 (3.1- 274.7). Patients with a large PTV (>60 cc) were associated with significantly poorer local control (5-year local control rate: 56%) and disease-specific survival (5-year survival rate: 53%). In patients with a small PTV (≤20 cc), there were no significant differences in local control among different T stages. Large NTV (>30 cc) was associated with significantly higher distant failure rate (5-year distant relapse-free survival rate: 54%) and lower disease-specific survival (5-year survival rate: 40%). In multivariate analysis, only PTV was found to be an independent factor in predicting local control. Conclusion: A large variation of tumor volume was present in different T stage disease of nasopharyngeal carcinoma, and PTV represents an independent prognostic factor of local control that appears to be more predictive than Ho's T stage classification.
Persistent Identifierhttp://hdl.handle.net/10722/71951
ISSN
2013 Impact Factor: 4.176
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChua, DTTen_HK
dc.contributor.authorSham, JSTen_HK
dc.contributor.authorKwong, DLWen_HK
dc.contributor.authorTai, KSen_HK
dc.contributor.authorWu, PMen_HK
dc.contributor.authorLo, Men_HK
dc.contributor.authorYung, Aen_HK
dc.contributor.authorChoy, Den_HK
dc.contributor.authorLeong, Len_HK
dc.date.accessioned2010-09-06T06:36:50Z-
dc.date.available2010-09-06T06:36:50Z-
dc.date.issued1997en_HK
dc.identifier.citationInternational Journal Of Radiation Oncology Biology Physics, 1997, v. 39 n. 3, p. 711-719en_HK
dc.identifier.issn0360-3016en_HK
dc.identifier.urihttp://hdl.handle.net/10722/71951-
dc.description.abstractPurpose: To investigate the variability of tumor volume in nasopharyngeal carcinoma using quantitative measurements of tumor hulk derived from computed tomography, and to study the prognostic value of tumor volume in comparison with other variables. Methods and Materials: Two hundred ninety patients with newly diagnosed nasopharyngeal carcinoma were included in the study. The primary tumor volume (PTV) and nodal tumor volume (NTV) were obtained by outlining the tumor contour followed by summation of areas in sequential pretreatment computed tomography axial scans. Total tumor volume (TTV) was obtained by adding the PTV and NTV. All patients had radiotherapy as the primary treatment, 67 patients also received cisplatin- based neoadjuvant chemotheraphy. Results: A large variation in tumor volume was observed, especially in advanced stage disease. The median PTV (cc) in Ho's T1, T2, and T3 disease were: 6.9 (range: 0.9 - 42.7), 18.8 (1.6-127.9), and 52.4 (3.3-166.8). The median TTV (cc) in Ho's stage I to IV disease were: 7.6 (range: 1.3-42.7), 19.8 (3.2-55.7), 40.7 (4.1-222.7), and 51.1 (3.1- 274.7). Patients with a large PTV (>60 cc) were associated with significantly poorer local control (5-year local control rate: 56%) and disease-specific survival (5-year survival rate: 53%). In patients with a small PTV (≤20 cc), there were no significant differences in local control among different T stages. Large NTV (>30 cc) was associated with significantly higher distant failure rate (5-year distant relapse-free survival rate: 54%) and lower disease-specific survival (5-year survival rate: 40%). In multivariate analysis, only PTV was found to be an independent factor in predicting local control. Conclusion: A large variation of tumor volume was present in different T stage disease of nasopharyngeal carcinoma, and PTV represents an independent prognostic factor of local control that appears to be more predictive than Ho's T stage classification.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/ijrobpen_HK
dc.relation.ispartofInternational Journal of Radiation Oncology Biology Physicsen_HK
dc.rightsInternational Journal of Radiation: Oncology - Biology - Physics. Copyright © Elsevier Inc.en_HK
dc.subjectComputed tomographyen_HK
dc.subjectLocal controlen_HK
dc.subjectNasopharyngeal carcinomaen_HK
dc.subjectRadiotherapyen_HK
dc.subjectTumor volumeen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAnalysis of Varianceen_HK
dc.subject.meshAntineoplastic Combined Chemotherapy Protocols - therapeutic useen_HK
dc.subject.meshCarcinoma - drug therapy - pathology - radiography - radiotherapyen_HK
dc.subject.meshChemotherapy, Adjuvanten_HK
dc.subject.meshCisplatin - administration & dosageen_HK
dc.subject.meshDose Fractionationen_HK
dc.subject.meshEpirubicin - administration & dosageen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshNasopharyngeal Neoplasms - drug therapy - pathology - radiography - radiotherapyen_HK
dc.subject.meshNeoplasm Stagingen_HK
dc.subject.meshPrognosisen_HK
dc.subject.meshRandomized Controlled Trials as Topicen_HK
dc.subject.meshRetrospective Studiesen_HK
dc.subject.meshTomography, X-Ray Computeden_HK
dc.subject.meshTreatment Outcomeen_HK
dc.titleVolumetric analysis of tumor extent in nasopharyngeal carcinoma and correlation with treatment outcomeen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0360-3016&volume=39&spage=703&epage=710&date=1997&atitle=Volumetric+analysis+of+tumor+extent+in+nasopharyngeal+carcinoma+and+correlation+with+treatment+outcomeen_HK
dc.identifier.emailChua, DTT: dttchua@hkucc.hku.hken_HK
dc.identifier.emailKwong, DLW: dlwkwong@hku.hken_HK
dc.identifier.authorityChua, DTT=rp00415en_HK
dc.identifier.authorityKwong, DLW=rp00414en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0360-3016(97)00374-Xen_HK
dc.identifier.pmid9336154en_HK
dc.identifier.scopuseid_2-s2.0-0030986414en_HK
dc.identifier.hkuros34746en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030986414&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume39en_HK
dc.identifier.issue3en_HK
dc.identifier.spage711en_HK
dc.identifier.epage719en_HK
dc.identifier.isiWOS:A1997YA91700027-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridChua, DTT=7006773480en_HK
dc.identifier.scopusauthoridSham, JST=24472255400en_HK
dc.identifier.scopusauthoridKwong, DLW=15744231600en_HK
dc.identifier.scopusauthoridTai, KS=7101738949en_HK
dc.identifier.scopusauthoridWu, PM=8663653900en_HK
dc.identifier.scopusauthoridLo, M=7101897477en_HK
dc.identifier.scopusauthoridYung, A=17837027200en_HK
dc.identifier.scopusauthoridChoy, D=7102939127en_HK
dc.identifier.scopusauthoridLeong, L=7004323766en_HK

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