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Article: White-matter diffusion anisotropy after chemo-irradiation: A statistical parametric mapping study and histogram analysis

TitleWhite-matter diffusion anisotropy after chemo-irradiation: A statistical parametric mapping study and histogram analysis
Authors
KeywordsMedulloblastoma survivors
Neurotoxicity
White-matter diffusion anisotrophy
Issue Date2004
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ynimg
Citation
Neuroimage, 2004, v. 21 n. 1, p. 261-268 How to Cite?
AbstractThe aim of the study was to evaluate white-matter (WM) diffusion anisotropy in medulloblastoma survivors after cranial irradiation and chemotherapy using voxel-based analysis with SPM99 and fractional anisotropy (FA) histogram-derived indices, and to identify quantitative indices for detecting and monitoring children with treatment-induced white-matter injury. Familywise error rate (FWE) that corrects for multiple comparisons was used to locate statistically significant regions of P < 0.05 in voxel-based analysis. Subsequently, the false discovery rate (FDR) controlling procedure (corrected P < 0.05) was used. FA map histogram analysis of histogram-derived indices, mean FA, mean FA peak height, and peak location was performed. Two-sample t test was used in all analyses. Using FWE-corrected P < 0.05, there was a cluster of reduced anisotropy in the periventricular white matter lateral to the left ventricular atrium. When FDR-corrected P < 0.05 was used, there were multiple clusters of reduced anisotropy in the periventricular white matter, the corpus callosum, and corona radiata. Simplified voxel-based morphometry (VBM)-like analysis of cerebrospinal fluid (CSF) did not show significant differences between patient and control subjects. 'White-matter FA map' histogram showed significant reduction in mean FA and mean FA peak location and significant increase in mean FA peak height in the patient group compared to control subjects (P = 0.003, P = 0.003, and P = 0.014, respectively). This approach of quantifying FA can be applied to characterize anisotropy in the white matter after cranial irradiation and chemotherapy and can potentially be used to detect and monitor treatment-induced neurotoxicity. © 2003 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/71948
ISSN
2014 Impact Factor: 6.357
2014 SCImago Journal Rankings: 3.549
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLeung, LHTen_HK
dc.contributor.authorOoi, GCen_HK
dc.contributor.authorKwong, DLWen_HK
dc.contributor.authorChan, GCFen_HK
dc.contributor.authorCao, Gen_HK
dc.contributor.authorKhong, PLen_HK
dc.date.accessioned2010-09-06T06:36:48Z-
dc.date.available2010-09-06T06:36:48Z-
dc.date.issued2004en_HK
dc.identifier.citationNeuroimage, 2004, v. 21 n. 1, p. 261-268en_HK
dc.identifier.issn1053-8119en_HK
dc.identifier.urihttp://hdl.handle.net/10722/71948-
dc.description.abstractThe aim of the study was to evaluate white-matter (WM) diffusion anisotropy in medulloblastoma survivors after cranial irradiation and chemotherapy using voxel-based analysis with SPM99 and fractional anisotropy (FA) histogram-derived indices, and to identify quantitative indices for detecting and monitoring children with treatment-induced white-matter injury. Familywise error rate (FWE) that corrects for multiple comparisons was used to locate statistically significant regions of P < 0.05 in voxel-based analysis. Subsequently, the false discovery rate (FDR) controlling procedure (corrected P < 0.05) was used. FA map histogram analysis of histogram-derived indices, mean FA, mean FA peak height, and peak location was performed. Two-sample t test was used in all analyses. Using FWE-corrected P < 0.05, there was a cluster of reduced anisotropy in the periventricular white matter lateral to the left ventricular atrium. When FDR-corrected P < 0.05 was used, there were multiple clusters of reduced anisotropy in the periventricular white matter, the corpus callosum, and corona radiata. Simplified voxel-based morphometry (VBM)-like analysis of cerebrospinal fluid (CSF) did not show significant differences between patient and control subjects. 'White-matter FA map' histogram showed significant reduction in mean FA and mean FA peak location and significant increase in mean FA peak height in the patient group compared to control subjects (P = 0.003, P = 0.003, and P = 0.014, respectively). This approach of quantifying FA can be applied to characterize anisotropy in the white matter after cranial irradiation and chemotherapy and can potentially be used to detect and monitor treatment-induced neurotoxicity. © 2003 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ynimgen_HK
dc.relation.ispartofNeuroImageen_HK
dc.subjectMedulloblastoma survivorsen_HK
dc.subjectNeurotoxicityen_HK
dc.subjectWhite-matter diffusion anisotrophyen_HK
dc.subject.meshAdolescenten_HK
dc.subject.meshAnisotropyen_HK
dc.subject.meshAntineoplastic Combined Chemotherapy Protocols - administration & dosageen_HK
dc.subject.meshCerebellar Neoplasms - diagnosis - drug therapy - radiotherapyen_HK
dc.subject.meshChemotherapy, Adjuvanten_HK
dc.subject.meshChilden_HK
dc.subject.meshChild, Preschoolen_HK
dc.subject.meshCohort Studiesen_HK
dc.subject.meshCombined Modality Therapyen_HK
dc.subject.meshCranial Irradiationen_HK
dc.subject.meshDiffusion Magnetic Resonance Imagingen_HK
dc.subject.meshDominance, Cerebral - physiologyen_HK
dc.subject.meshDose Fractionationen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshFollow-Up Studiesen_HK
dc.subject.meshHumansen_HK
dc.subject.meshImage Enhancementen_HK
dc.subject.meshImage Processing, Computer-Assisteden_HK
dc.subject.meshMagnetic Resonance Imagingen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMedulloblastoma - diagnosis - drug therapy - radiotherapyen_HK
dc.subject.meshNerve Fibers, Myelinated - drug effects - pathology - radiation effectsen_HK
dc.titleWhite-matter diffusion anisotropy after chemo-irradiation: A statistical parametric mapping study and histogram analysisen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1053-8119&volume=21&issue=1&spage=261&epage=268&date=2004&atitle=White-matter+diffusion+anisotropy+after+chemo-irradiation:+a+statistical+parametric+mapping+study+and+histogram+analysisen_HK
dc.identifier.emailKwong, DLW:dlwkwong@hku.hken_HK
dc.identifier.emailChan, GCF:gcfchan@hkucc.hku.hken_HK
dc.identifier.emailKhong, PL:plkhong@hkucc.hku.hken_HK
dc.identifier.authorityKwong, DLW=rp00414en_HK
dc.identifier.authorityChan, GCF=rp00431en_HK
dc.identifier.authorityKhong, PL=rp00467en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.neuroimage.2003.09.020en_HK
dc.identifier.pmid14741664-
dc.identifier.scopuseid_2-s2.0-1642451926en_HK
dc.identifier.hkuros85586en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-1642451926&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume21en_HK
dc.identifier.issue1en_HK
dc.identifier.spage261en_HK
dc.identifier.epage268en_HK
dc.identifier.isiWOS:000188597500028-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLeung, LHT=7202048113en_HK
dc.identifier.scopusauthoridOoi, GC=16239781100en_HK
dc.identifier.scopusauthoridKwong, DLW=15744231600en_HK
dc.identifier.scopusauthoridChan, GCF=16160154400en_HK
dc.identifier.scopusauthoridCao, G=12776387400en_HK
dc.identifier.scopusauthoridKhong, PL=7006693233en_HK

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