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Article: White-matter diffusion anisotropy after chemo-irradiation: A statistical parametric mapping study and histogram analysis
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TitleWhite-matter diffusion anisotropy after chemo-irradiation: A statistical parametric mapping study and histogram analysis
 
AuthorsLeung, LHT2
Ooi, GC2
Kwong, DLW2
Chan, GCF2
Cao, G1
Khong, PL2
 
KeywordsMedulloblastoma survivors
Neurotoxicity
White-matter diffusion anisotrophy
 
Issue Date2004
 
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ynimg
 
CitationNeuroimage, 2004, v. 21 n. 1, p. 261-268 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.neuroimage.2003.09.020
 
AbstractThe aim of the study was to evaluate white-matter (WM) diffusion anisotropy in medulloblastoma survivors after cranial irradiation and chemotherapy using voxel-based analysis with SPM99 and fractional anisotropy (FA) histogram-derived indices, and to identify quantitative indices for detecting and monitoring children with treatment-induced white-matter injury. Familywise error rate (FWE) that corrects for multiple comparisons was used to locate statistically significant regions of P < 0.05 in voxel-based analysis. Subsequently, the false discovery rate (FDR) controlling procedure (corrected P < 0.05) was used. FA map histogram analysis of histogram-derived indices, mean FA, mean FA peak height, and peak location was performed. Two-sample t test was used in all analyses. Using FWE-corrected P < 0.05, there was a cluster of reduced anisotropy in the periventricular white matter lateral to the left ventricular atrium. When FDR-corrected P < 0.05 was used, there were multiple clusters of reduced anisotropy in the periventricular white matter, the corpus callosum, and corona radiata. Simplified voxel-based morphometry (VBM)-like analysis of cerebrospinal fluid (CSF) did not show significant differences between patient and control subjects. 'White-matter FA map' histogram showed significant reduction in mean FA and mean FA peak location and significant increase in mean FA peak height in the patient group compared to control subjects (P = 0.003, P = 0.003, and P = 0.014, respectively). This approach of quantifying FA can be applied to characterize anisotropy in the white matter after cranial irradiation and chemotherapy and can potentially be used to detect and monitor treatment-induced neurotoxicity. © 2003 Elsevier Inc. All rights reserved.
 
ISSN1053-8119
2013 Impact Factor: 6.132
 
DOIhttp://dx.doi.org/10.1016/j.neuroimage.2003.09.020
 
ISI Accession Number IDWOS:000188597500028
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorLeung, LHT
 
dc.contributor.authorOoi, GC
 
dc.contributor.authorKwong, DLW
 
dc.contributor.authorChan, GCF
 
dc.contributor.authorCao, G
 
dc.contributor.authorKhong, PL
 
dc.date.accessioned2010-09-06T06:36:48Z
 
dc.date.available2010-09-06T06:36:48Z
 
dc.date.issued2004
 
dc.description.abstractThe aim of the study was to evaluate white-matter (WM) diffusion anisotropy in medulloblastoma survivors after cranial irradiation and chemotherapy using voxel-based analysis with SPM99 and fractional anisotropy (FA) histogram-derived indices, and to identify quantitative indices for detecting and monitoring children with treatment-induced white-matter injury. Familywise error rate (FWE) that corrects for multiple comparisons was used to locate statistically significant regions of P < 0.05 in voxel-based analysis. Subsequently, the false discovery rate (FDR) controlling procedure (corrected P < 0.05) was used. FA map histogram analysis of histogram-derived indices, mean FA, mean FA peak height, and peak location was performed. Two-sample t test was used in all analyses. Using FWE-corrected P < 0.05, there was a cluster of reduced anisotropy in the periventricular white matter lateral to the left ventricular atrium. When FDR-corrected P < 0.05 was used, there were multiple clusters of reduced anisotropy in the periventricular white matter, the corpus callosum, and corona radiata. Simplified voxel-based morphometry (VBM)-like analysis of cerebrospinal fluid (CSF) did not show significant differences between patient and control subjects. 'White-matter FA map' histogram showed significant reduction in mean FA and mean FA peak location and significant increase in mean FA peak height in the patient group compared to control subjects (P = 0.003, P = 0.003, and P = 0.014, respectively). This approach of quantifying FA can be applied to characterize anisotropy in the white matter after cranial irradiation and chemotherapy and can potentially be used to detect and monitor treatment-induced neurotoxicity. © 2003 Elsevier Inc. All rights reserved.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationNeuroimage, 2004, v. 21 n. 1, p. 261-268 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.neuroimage.2003.09.020
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.neuroimage.2003.09.020
 
dc.identifier.epage268
 
dc.identifier.hkuros85586
 
dc.identifier.isiWOS:000188597500028
 
dc.identifier.issn1053-8119
2013 Impact Factor: 6.132
 
dc.identifier.issue1
 
dc.identifier.openurl
 
dc.identifier.pmid14741664
 
dc.identifier.scopuseid_2-s2.0-1642451926
 
dc.identifier.spage261
 
dc.identifier.urihttp://hdl.handle.net/10722/71948
 
dc.identifier.volume21
 
dc.languageeng
 
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ynimg
 
dc.publisher.placeUnited States
 
dc.relation.ispartofNeuroImage
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAdolescent
 
dc.subject.meshAnisotropy
 
dc.subject.meshAntineoplastic Combined Chemotherapy Protocols - administration & dosage
 
dc.subject.meshCerebellar Neoplasms - diagnosis - drug therapy - radiotherapy
 
dc.subject.meshChemotherapy, Adjuvant
 
dc.subject.meshChild
 
dc.subject.meshChild, Preschool
 
dc.subject.meshCohort Studies
 
dc.subject.meshCombined Modality Therapy
 
dc.subject.meshCranial Irradiation
 
dc.subject.meshDiffusion Magnetic Resonance Imaging
 
dc.subject.meshDominance, Cerebral - physiology
 
dc.subject.meshDose Fractionation
 
dc.subject.meshFemale
 
dc.subject.meshFollow-Up Studies
 
dc.subject.meshHumans
 
dc.subject.meshImage Enhancement
 
dc.subject.meshImage Processing, Computer-Assisted
 
dc.subject.meshMagnetic Resonance Imaging
 
dc.subject.meshMale
 
dc.subject.meshMedulloblastoma - diagnosis - drug therapy - radiotherapy
 
dc.subject.meshNerve Fibers, Myelinated - drug effects - pathology - radiation effects
 
dc.subjectMedulloblastoma survivors
 
dc.subjectNeurotoxicity
 
dc.subjectWhite-matter diffusion anisotrophy
 
dc.titleWhite-matter diffusion anisotropy after chemo-irradiation: A statistical parametric mapping study and histogram analysis
 
dc.typeArticle
 
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Author Affiliations
  1. GE Medical Systems
  2. The University of Hong Kong