Article: White-matter diffusion anisotropy after chemo-irradiation: A statistical parametric mapping study and histogram analysis

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TitleWhite-matter diffusion anisotropy after chemo-irradiation: A statistical parametric mapping study and histogram analysis
AuthorsLeung, LHT2
Ooi, GC2
Kwong, DLW2
Chan, GCF2
Cao, G1
Khong, PL2
KeywordsMedulloblastoma survivors
Neurotoxicity
White-matter diffusion anisotrophy
Issue Date2004
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ynimg
CitationNeuroimage, 2004, v. 21 n. 1, p. 261-268 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.neuroimage.2003.09.020
AbstractThe aim of the study was to evaluate white-matter (WM) diffusion anisotropy in medulloblastoma survivors after cranial irradiation and chemotherapy using voxel-based analysis with SPM99 and fractional anisotropy (FA) histogram-derived indices, and to identify quantitative indices for detecting and monitoring children with treatment-induced white-matter injury. Familywise error rate (FWE) that corrects for multiple comparisons was used to locate statistically significant regions of P < 0.05 in voxel-based analysis. Subsequently, the false discovery rate (FDR) controlling procedure (corrected P < 0.05) was used. FA map histogram analysis of histogram-derived indices, mean FA, mean FA peak height, and peak location was performed. Two-sample t test was used in all analyses. Using FWE-corrected P < 0.05, there was a cluster of reduced anisotropy in the periventricular white matter lateral to the left ventricular atrium. When FDR-corrected P < 0.05 was used, there were multiple clusters of reduced anisotropy in the periventricular white matter, the corpus callosum, and corona radiata. Simplified voxel-based morphometry (VBM)-like analysis of cerebrospinal fluid (CSF) did not show significant differences between patient and control subjects. 'White-matter FA map' histogram showed significant reduction in mean FA and mean FA peak location and significant increase in mean FA peak height in the patient group compared to control subjects (P = 0.003, P = 0.003, and P = 0.014, respectively). This approach of quantifying FA can be applied to characterize anisotropy in the white matter after cranial irradiation and chemotherapy and can potentially be used to detect and monitor treatment-induced neurotoxicity. © 2003 Elsevier Inc. All rights reserved.
ISSN1053-8119
2011 Impact Factor: 5.895
2011 SCImago Journal Rankings: 0.450
DOIhttp://dx.doi.org/10.1016/j.neuroimage.2003.09.020
ISI Accession Number IDWOS:000188597500028
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorLeung, LHT
dc.contributor.authorOoi, GC
dc.contributor.authorKwong, DLW
dc.contributor.authorChan, GCF
dc.contributor.authorCao, G
dc.contributor.authorKhong, PL
dc.date.accessioned2010-09-06T06:36:48Z
dc.date.available2010-09-06T06:36:48Z
dc.date.issued2004
dc.description.abstractThe aim of the study was to evaluate white-matter (WM) diffusion anisotropy in medulloblastoma survivors after cranial irradiation and chemotherapy using voxel-based analysis with SPM99 and fractional anisotropy (FA) histogram-derived indices, and to identify quantitative indices for detecting and monitoring children with treatment-induced white-matter injury. Familywise error rate (FWE) that corrects for multiple comparisons was used to locate statistically significant regions of P < 0.05 in voxel-based analysis. Subsequently, the false discovery rate (FDR) controlling procedure (corrected P < 0.05) was used. FA map histogram analysis of histogram-derived indices, mean FA, mean FA peak height, and peak location was performed. Two-sample t test was used in all analyses. Using FWE-corrected P < 0.05, there was a cluster of reduced anisotropy in the periventricular white matter lateral to the left ventricular atrium. When FDR-corrected P < 0.05 was used, there were multiple clusters of reduced anisotropy in the periventricular white matter, the corpus callosum, and corona radiata. Simplified voxel-based morphometry (VBM)-like analysis of cerebrospinal fluid (CSF) did not show significant differences between patient and control subjects. 'White-matter FA map' histogram showed significant reduction in mean FA and mean FA peak location and significant increase in mean FA peak height in the patient group compared to control subjects (P = 0.003, P = 0.003, and P = 0.014, respectively). This approach of quantifying FA can be applied to characterize anisotropy in the white matter after cranial irradiation and chemotherapy and can potentially be used to detect and monitor treatment-induced neurotoxicity. © 2003 Elsevier Inc. All rights reserved.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationNeuroimage, 2004, v. 21 n. 1, p. 261-268 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.neuroimage.2003.09.020
dc.identifier.doihttp://dx.doi.org/10.1016/j.neuroimage.2003.09.020
dc.identifier.epage268
dc.identifier.hkuros85586
dc.identifier.isiWOS:000188597500028
dc.identifier.issn1053-8119
2011 Impact Factor: 5.895
2011 SCImago Journal Rankings: 0.450
dc.identifier.issue1
dc.identifier.openurl
dc.identifier.pmid14741664
dc.identifier.scopuseid_2-s2.0-1642451926
dc.identifier.spage261
dc.identifier.urihttp://hdl.handle.net/10722/71948
dc.identifier.volume21
dc.languageeng
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ynimg
dc.publisher.placeUnited States
dc.relation.ispartofNeuroImage
dc.relation.referencesReferences in Scopus
dc.subject.meshAdolescent
dc.subject.meshAnisotropy
dc.subject.meshAntineoplastic Combined Chemotherapy Protocols - administration & dosage
dc.subject.meshCerebellar Neoplasms - diagnosis - drug therapy - radiotherapy
dc.subject.meshChemotherapy, Adjuvant
dc.subject.meshChild
dc.subject.meshChild, Preschool
dc.subject.meshCohort Studies
dc.subject.meshCombined Modality Therapy
dc.subject.meshCranial Irradiation
dc.subject.meshDiffusion Magnetic Resonance Imaging
dc.subject.meshDominance, Cerebral - physiology
dc.subject.meshDose Fractionation
dc.subject.meshFemale
dc.subject.meshFollow-Up Studies
dc.subject.meshHumans
dc.subject.meshImage Enhancement
dc.subject.meshImage Processing, Computer-Assisted
dc.subject.meshMagnetic Resonance Imaging
dc.subject.meshMale
dc.subject.meshMedulloblastoma - diagnosis - drug therapy - radiotherapy
dc.subject.meshNerve Fibers, Myelinated - drug effects - pathology - radiation effects
dc.subjectMedulloblastoma survivors
dc.subjectNeurotoxicity
dc.subjectWhite-matter diffusion anisotrophy
dc.titleWhite-matter diffusion anisotropy after chemo-irradiation: A statistical parametric mapping study and histogram analysis
dc.typeArticle
Author Affiliations
  1. GE Medical Systems
  2. The University of Hong Kong