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Article: Recurrent chromosome alterations in primary ovarian carcinoma in Chinese women

TitleRecurrent chromosome alterations in primary ovarian carcinoma in Chinese women
Authors
Issue Date2002
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergene
Citation
Cancer Genetics And Cytogenetics, 2002, v. 133 n. 1, p. 39-44 How to Cite?
AbstractOvarian cancer is one of the most frequent gynecological malignancies worldwide with a poor prognosis. Comparative genomic hybridization has been applied to detect recurrent chromosome alterations in 31 primary ovarian carcinomas in Chinese women. Several nonrandom chromosomal changes were identified including gains of 3q (17 cases, 55%) with a minimum region at 3q25∼q26, 8q (16 cases, 52%), 19q (12 cases, 39%), Xq (11 cases, 35%), 1q (10 cases, 32%), 12p12∼q13 (10 cases, 32%), 17q (10 cases, 32%) with a minimum gain region at 17q21, and 20q (9 cases, 29%); and losses of 16q (9 cases, 29%), 1p (7 cases, 23%), 18q (7 cases, 23%), and 22 (7 cases, 23%). High-copy-number amplification was detected in eleven cases. Amplification of 3q25∼q26 was detected in four cases, and amplifications of 8q24 and 12p11.2∼q12 were observed in three cases each. The recurrent gains and losses of chromosomal regions identified in this study provide candidate regions that may contain oncogenes or tumor suppressor genes involved in the development and progression of ovarian cancer. © 2002 Elsevier Science Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/71947
ISSN
2012 Impact Factor: 1.929
2013 SCImago Journal Rankings: 0.872
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSham, JSTen_HK
dc.contributor.authorTang, TCMen_HK
dc.contributor.authorFang, Yen_HK
dc.contributor.authorSun, Len_HK
dc.contributor.authorQin, LXen_HK
dc.contributor.authorWu, QLen_HK
dc.contributor.authorXie, Den_HK
dc.contributor.authorGuan, XYen_HK
dc.date.accessioned2010-09-06T06:36:47Z-
dc.date.available2010-09-06T06:36:47Z-
dc.date.issued2002en_HK
dc.identifier.citationCancer Genetics And Cytogenetics, 2002, v. 133 n. 1, p. 39-44en_HK
dc.identifier.issn0165-4608en_HK
dc.identifier.urihttp://hdl.handle.net/10722/71947-
dc.description.abstractOvarian cancer is one of the most frequent gynecological malignancies worldwide with a poor prognosis. Comparative genomic hybridization has been applied to detect recurrent chromosome alterations in 31 primary ovarian carcinomas in Chinese women. Several nonrandom chromosomal changes were identified including gains of 3q (17 cases, 55%) with a minimum region at 3q25∼q26, 8q (16 cases, 52%), 19q (12 cases, 39%), Xq (11 cases, 35%), 1q (10 cases, 32%), 12p12∼q13 (10 cases, 32%), 17q (10 cases, 32%) with a minimum gain region at 17q21, and 20q (9 cases, 29%); and losses of 16q (9 cases, 29%), 1p (7 cases, 23%), 18q (7 cases, 23%), and 22 (7 cases, 23%). High-copy-number amplification was detected in eleven cases. Amplification of 3q25∼q26 was detected in four cases, and amplifications of 8q24 and 12p11.2∼q12 were observed in three cases each. The recurrent gains and losses of chromosomal regions identified in this study provide candidate regions that may contain oncogenes or tumor suppressor genes involved in the development and progression of ovarian cancer. © 2002 Elsevier Science Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergeneen_HK
dc.relation.ispartofCancer Genetics and Cytogeneticsen_HK
dc.rightsCancer Genetics and Cytogenetics. Copyright © Elsevier Inc.en_HK
dc.subject.meshAdenocarcinoma - geneticsen_HK
dc.subject.meshChinaen_HK
dc.subject.meshChromosome Aberrationsen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGene Amplificationen_HK
dc.subject.meshGenetic Markersen_HK
dc.subject.meshHumansen_HK
dc.subject.meshNucleic Acid Hybridizationen_HK
dc.subject.meshOvarian Neoplasms - geneticsen_HK
dc.titleRecurrent chromosome alterations in primary ovarian carcinoma in Chinese womenen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0165-4608&volume=133&spage=39&epage=44&date=2002&atitle=Recurrent+chromosome+alterations+in+primary+ovarian+carcinoma+in+Chinese+womenen_HK
dc.identifier.emailGuan, XY:xyguan@hkucc.hku.hken_HK
dc.identifier.authorityGuan, XY=rp00454en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0165-4608(01)00567-2en_HK
dc.identifier.pmid11890988-
dc.identifier.scopuseid_2-s2.0-0036118750en_HK
dc.identifier.hkuros72182en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036118750&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume133en_HK
dc.identifier.issue1en_HK
dc.identifier.spage39en_HK
dc.identifier.epage44en_HK
dc.identifier.isiWOS:000174390600005-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridSham, JST=7101655565en_HK
dc.identifier.scopusauthoridTang, TCM=36867093400en_HK
dc.identifier.scopusauthoridFang, Y=7403457405en_HK
dc.identifier.scopusauthoridSun, L=37060226200en_HK
dc.identifier.scopusauthoridQin, LX=16747601200en_HK
dc.identifier.scopusauthoridWu, QL=7404602639en_HK
dc.identifier.scopusauthoridXie, D=35070710200en_HK
dc.identifier.scopusauthoridGuan, XY=7201463221en_HK

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