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Article: The effect of loco-regional control on distant metastatic dissemination in carcinoma of the nasopharynx: An analysis of 1301 patients

TitleThe effect of loco-regional control on distant metastatic dissemination in carcinoma of the nasopharynx: An analysis of 1301 patients
Authors
Issue Date1994
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/ijrobp
Citation
International Journal of Radiation Oncology - Biology - Physics, 1994, v. 30 n. 5, p. 1029-1036 How to Cite?
AbstractPurpose: This study evaluated the effect of loco-regional control on incidence of distant metastases in patients with nasopharyngeal carcinoma. Methods and Materials: Retrospective analysis was performed on 1301 patients with nasopharyngeal carcinoma treated from 1976-1989 in our hospital. The effect of different prognostic indicators on distant metastases free survival (DMFS) was analyzed, including T stage, N stage, sex, and loco-regional control. The significance of loco-regional control in distant metastatic dissemination was further studied with period and subgroup analysis. Cox regression was performed to identify the independent prognostic variables. Results: Patients with loco-regional relapse had significantly higher distant metastases rate than patients with loco-regional control (time-adjusted distant metastases rate at 5 years was 40.7% vs. 29.4%, p = 0.0012). By period analysis, the effect of loco-regional control on distant metastases was found to be significant in the first 2 years from diagnosis. Subgroup analysis showed that loco-regional relapse was associated with significantly higher distant metastases rate in patients with T1, N0, and N1 disease (p = 0.001, 0.001, 0.0226, respectively). The Cox regression model also confirmed loco-regional control as an independent prognostic indicator of distant metastases (p = 0.0001) besides T stage (p = 0.0006) and N stage (p = 0.0001). Conclusion: Loco-regional relapse is a significant risk factor for development of distant metastases. Further effort should be made to improve loco-regional control and to eradicate distant metastases.
Persistent Identifierhttp://hdl.handle.net/10722/71934
ISSN
2015 Impact Factor: 4.495
2015 SCImago Journal Rankings: 2.274
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKwong, Den_HK
dc.contributor.authorSham, Jen_HK
dc.contributor.authorChoy, Den_HK
dc.date.accessioned2010-09-06T06:36:39Z-
dc.date.available2010-09-06T06:36:39Z-
dc.date.issued1994en_HK
dc.identifier.citationInternational Journal of Radiation Oncology - Biology - Physics, 1994, v. 30 n. 5, p. 1029-1036en_HK
dc.identifier.issn0360-3016en_HK
dc.identifier.urihttp://hdl.handle.net/10722/71934-
dc.description.abstractPurpose: This study evaluated the effect of loco-regional control on incidence of distant metastases in patients with nasopharyngeal carcinoma. Methods and Materials: Retrospective analysis was performed on 1301 patients with nasopharyngeal carcinoma treated from 1976-1989 in our hospital. The effect of different prognostic indicators on distant metastases free survival (DMFS) was analyzed, including T stage, N stage, sex, and loco-regional control. The significance of loco-regional control in distant metastatic dissemination was further studied with period and subgroup analysis. Cox regression was performed to identify the independent prognostic variables. Results: Patients with loco-regional relapse had significantly higher distant metastases rate than patients with loco-regional control (time-adjusted distant metastases rate at 5 years was 40.7% vs. 29.4%, p = 0.0012). By period analysis, the effect of loco-regional control on distant metastases was found to be significant in the first 2 years from diagnosis. Subgroup analysis showed that loco-regional relapse was associated with significantly higher distant metastases rate in patients with T1, N0, and N1 disease (p = 0.001, 0.001, 0.0226, respectively). The Cox regression model also confirmed loco-regional control as an independent prognostic indicator of distant metastases (p = 0.0001) besides T stage (p = 0.0006) and N stage (p = 0.0001). Conclusion: Loco-regional relapse is a significant risk factor for development of distant metastases. Further effort should be made to improve loco-regional control and to eradicate distant metastases.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/ijrobpen_HK
dc.relation.ispartofInternational Journal of Radiation Oncology - Biology - Physicsen_HK
dc.rightsInternational Journal of Radiation: Oncology - Biology - Physics. Copyright © Elsevier Inc.en_HK
dc.subject.meshAdolescenten_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshAged, 80 and overen_HK
dc.subject.meshDisease-Free Survivalen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshNasopharyngeal Neoplasms - mortality - pathology - radiotherapyen_HK
dc.subject.meshNeoplasm Metastasis - prevention & controlen_HK
dc.subject.meshNeoplasm Stagingen_HK
dc.subject.meshPrognosisen_HK
dc.subject.meshProportional Hazards Modelsen_HK
dc.subject.meshRecurrenceen_HK
dc.subject.meshRegression Analysisen_HK
dc.subject.meshRetrospective Studiesen_HK
dc.subject.meshSex Characteristicsen_HK
dc.titleThe effect of loco-regional control on distant metastatic dissemination in carcinoma of the nasopharynx: An analysis of 1301 patientsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0360-3016&volume=30&spage=1029&epage=1036&date=1994&atitle=The+effect+of+loco-regional+control+on+distant+metastatic+dissemination+in+carcinoma+of+the+nasopharynx:+an+analysis+of+1301+patientsen_HK
dc.identifier.emailKwong, D:dlwkwong@hku.hken_HK
dc.identifier.authorityKwong, D=rp00414en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid7961008-
dc.identifier.scopuseid_2-s2.0-0027939102en_HK
dc.identifier.hkuros2558en_HK
dc.identifier.volume30en_HK
dc.identifier.issue5en_HK
dc.identifier.spage1029en_HK
dc.identifier.epage1036en_HK
dc.identifier.isiWOS:A1994PT59800003-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridKwong, D=15744231600en_HK
dc.identifier.scopusauthoridSham, J=7101655565en_HK
dc.identifier.scopusauthoridChoy, D=7102939127en_HK

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