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Article: Intensive expression of Bmi-1 is a new independent predictor of poor outcome in patients with ovarian carcinoma

TitleIntensive expression of Bmi-1 is a new independent predictor of poor outcome in patients with ovarian carcinoma
Authors
Issue Date2010
PublisherBioMed Central Ltd. The Journal's web site is located at http://www.biomedcentral.com/bmccancer/
Citation
Bmc Cancer, 2010, v. 10 How to Cite?
AbstractBackground: It has been suggested that the B-cell specific moloney leukemia virus insertion site 1 (Bmi-1) gene plays an oncogenic role in several types of human cancer, but the status of Bmi-1 amplification and expression in ovarian cancer and its clinical/prognostic significance are unclear.Methods: The methods of immunohistochemistry and fluorescence in situ hybridization were utilized to examine protein expression and amplification of Bmi-1 in 30 normal ovaries, 30 ovarian cystadenomas, 40 borderline ovarian tumors and 179 ovarian carcinomas.Results: Intensive expression of Bmi-1 was detected in none of the normal ovaries, 3% cystadenomas, 10% borderline tumors, and 37% ovarian carcinomas, respectively. Amplification of Bmi-1 was detected in 8% of ovarian carcinomas. In ovarian carcinomas, significant positive associations were found between intensive expression of Bmi-1 and the tumors ascending histological grade, later pT/pN/pM and FIGO stages (P < 0.05). In univariate survival analysis of the ovarian carcinoma cohorts, a significant association of intensive expression of Bmi-1 with shortened patient survival (mean 49.3 months versus 100.3 months, p < 0.001) was demonstrated. Importantly, Bmi-1 expression provided significant independent prognostic parameters in multivariate analysis (p = 0.005).Conclusions: These findings provide evidence that intensive expression of Bmi-1 might be important in the acquisition of an invasive and/or aggressive phenotype of ovarian carcinoma, and serve as a independent biomarker for shortened survival time of patients. © 2010 Yang et al; licensee BioMed Central Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/71929
ISSN
2014 Impact Factor: 3.362
2014 SCImago Journal Rankings: 1.403
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
Major State Basic Research Program of China2006CB910104
Nature Science Foundation of China30772334
Project of Guangdong Science and Technology Agency2004B35001004
2005A30801001
Funding Information:

This study was supported by the grants from the the Major State Basic Research Program of China (2006CB910104), the Nature Science Foundation of China (No. 30772334) and Project of Guangdong Science and Technology Agency (No. 2004B35001004 and 2005A30801001).

References

 

DC FieldValueLanguage
dc.contributor.authorYang, GFen_HK
dc.contributor.authorHe, WPen_HK
dc.contributor.authorCai, MYen_HK
dc.contributor.authorHe, LRen_HK
dc.contributor.authorLuo, JHen_HK
dc.contributor.authorDeng, HXen_HK
dc.contributor.authorGuan, XYen_HK
dc.contributor.authorZeng, MSen_HK
dc.contributor.authorZeng, YXen_HK
dc.contributor.authorXie, Den_HK
dc.date.accessioned2010-09-06T06:36:36Z-
dc.date.available2010-09-06T06:36:36Z-
dc.date.issued2010en_HK
dc.identifier.citationBmc Cancer, 2010, v. 10en_HK
dc.identifier.issn1471-2407en_HK
dc.identifier.urihttp://hdl.handle.net/10722/71929-
dc.description.abstractBackground: It has been suggested that the B-cell specific moloney leukemia virus insertion site 1 (Bmi-1) gene plays an oncogenic role in several types of human cancer, but the status of Bmi-1 amplification and expression in ovarian cancer and its clinical/prognostic significance are unclear.Methods: The methods of immunohistochemistry and fluorescence in situ hybridization were utilized to examine protein expression and amplification of Bmi-1 in 30 normal ovaries, 30 ovarian cystadenomas, 40 borderline ovarian tumors and 179 ovarian carcinomas.Results: Intensive expression of Bmi-1 was detected in none of the normal ovaries, 3% cystadenomas, 10% borderline tumors, and 37% ovarian carcinomas, respectively. Amplification of Bmi-1 was detected in 8% of ovarian carcinomas. In ovarian carcinomas, significant positive associations were found between intensive expression of Bmi-1 and the tumors ascending histological grade, later pT/pN/pM and FIGO stages (P < 0.05). In univariate survival analysis of the ovarian carcinoma cohorts, a significant association of intensive expression of Bmi-1 with shortened patient survival (mean 49.3 months versus 100.3 months, p < 0.001) was demonstrated. Importantly, Bmi-1 expression provided significant independent prognostic parameters in multivariate analysis (p = 0.005).Conclusions: These findings provide evidence that intensive expression of Bmi-1 might be important in the acquisition of an invasive and/or aggressive phenotype of ovarian carcinoma, and serve as a independent biomarker for shortened survival time of patients. © 2010 Yang et al; licensee BioMed Central Ltd.en_HK
dc.languageengen_HK
dc.publisherBioMed Central Ltd. The Journal's web site is located at http://www.biomedcentral.com/bmccancer/en_HK
dc.relation.ispartofBMC Canceren_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshNuclear Proteins - biosynthesis - genetics-
dc.subject.meshOvarian Neoplasms - genetics - metabolism - pathology-
dc.subject.meshProto-Oncogene Proteins - biosynthesis - genetics-
dc.subject.meshRepressor Proteins - biosynthesis - genetics-
dc.subject.meshTumor Markers, Biological - biosynthesis - genetics-
dc.titleIntensive expression of Bmi-1 is a new independent predictor of poor outcome in patients with ovarian carcinomaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1471-2407&volume=10 article no. 133&spage=&epage=&date=2010&atitle=Intensive+expression+of+Bmi-1+is+a+new+independent+predictor+of+poor+outcome+in+patients+with+ovarian+carcinomaen_HK
dc.identifier.emailGuan, XY:xyguan@hkucc.hku.hken_HK
dc.identifier.authorityGuan, XY=rp00454en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1186/1471-2407-10-133en_HK
dc.identifier.pmid20377880-
dc.identifier.pmcidPMC2858112-
dc.identifier.scopuseid_2-s2.0-77950657234en_HK
dc.identifier.hkuros169643en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77950657234&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume10en_HK
dc.identifier.isiWOS:000277008400001-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridYang, GF=16064823400en_HK
dc.identifier.scopusauthoridHe, WP=35185088700en_HK
dc.identifier.scopusauthoridCai, MY=23388510500en_HK
dc.identifier.scopusauthoridHe, LR=35069492500en_HK
dc.identifier.scopusauthoridLuo, JH=7404183419en_HK
dc.identifier.scopusauthoridDeng, HX=24079601100en_HK
dc.identifier.scopusauthoridGuan, XY=7201463221en_HK
dc.identifier.scopusauthoridZeng, MS=10642267400en_HK
dc.identifier.scopusauthoridZeng, YX=7402981579en_HK
dc.identifier.scopusauthoridXie, D=35070710200en_HK
dc.identifier.citeulike7017250-

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