File Download
 
Links for fulltext
(May Require Subscription)
 
Supplementary

Article: Intensive expression of Bmi-1 is a new independent predictor of poor outcome in patients with ovarian carcinoma
  • Basic View
  • Metadata View
  • XML View
TitleIntensive expression of Bmi-1 is a new independent predictor of poor outcome in patients with ovarian carcinoma
 
AuthorsYang, GF1
He, WP1
Cai, MY1
He, LR1
Luo, JH1
Deng, HX1
Guan, XY1
Zeng, MS1
Zeng, YX1
Xie, D1
 
Issue Date2010
 
PublisherBioMed Central Ltd. The Journal's web site is located at http://www.biomedcentral.com/bmccancer/
 
CitationBmc Cancer, 2010, v. 10 [How to Cite?]
DOI: http://dx.doi.org/10.1186/1471-2407-10-133
 
AbstractBackground: It has been suggested that the B-cell specific moloney leukemia virus insertion site 1 (Bmi-1) gene plays an oncogenic role in several types of human cancer, but the status of Bmi-1 amplification and expression in ovarian cancer and its clinical/prognostic significance are unclear.Methods: The methods of immunohistochemistry and fluorescence in situ hybridization were utilized to examine protein expression and amplification of Bmi-1 in 30 normal ovaries, 30 ovarian cystadenomas, 40 borderline ovarian tumors and 179 ovarian carcinomas.Results: Intensive expression of Bmi-1 was detected in none of the normal ovaries, 3% cystadenomas, 10% borderline tumors, and 37% ovarian carcinomas, respectively. Amplification of Bmi-1 was detected in 8% of ovarian carcinomas. In ovarian carcinomas, significant positive associations were found between intensive expression of Bmi-1 and the tumors ascending histological grade, later pT/pN/pM and FIGO stages (P < 0.05). In univariate survival analysis of the ovarian carcinoma cohorts, a significant association of intensive expression of Bmi-1 with shortened patient survival (mean 49.3 months versus 100.3 months, p < 0.001) was demonstrated. Importantly, Bmi-1 expression provided significant independent prognostic parameters in multivariate analysis (p = 0.005).Conclusions: These findings provide evidence that intensive expression of Bmi-1 might be important in the acquisition of an invasive and/or aggressive phenotype of ovarian carcinoma, and serve as a independent biomarker for shortened survival time of patients. © 2010 Yang et al; licensee BioMed Central Ltd.
 
ISSN1471-2407
2012 Impact Factor: 3.333
2012 SCImago Journal Rankings: 1.331
 
DOIhttp://dx.doi.org/10.1186/1471-2407-10-133
 
PubMed Central IDPMC2858112
 
ISI Accession Number IDWOS:000277008400001
Funding AgencyGrant Number
Major State Basic Research Program of China2006CB910104
Nature Science Foundation of China30772334
Project of Guangdong Science and Technology Agency2004B35001004
2005A30801001
Funding Information:

This study was supported by the grants from the the Major State Basic Research Program of China (2006CB910104), the Nature Science Foundation of China (No. 30772334) and Project of Guangdong Science and Technology Agency (No. 2004B35001004 and 2005A30801001).

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorYang, GF
 
dc.contributor.authorHe, WP
 
dc.contributor.authorCai, MY
 
dc.contributor.authorHe, LR
 
dc.contributor.authorLuo, JH
 
dc.contributor.authorDeng, HX
 
dc.contributor.authorGuan, XY
 
dc.contributor.authorZeng, MS
 
dc.contributor.authorZeng, YX
 
dc.contributor.authorXie, D
 
dc.date.accessioned2010-09-06T06:36:36Z
 
dc.date.available2010-09-06T06:36:36Z
 
dc.date.issued2010
 
dc.description.abstractBackground: It has been suggested that the B-cell specific moloney leukemia virus insertion site 1 (Bmi-1) gene plays an oncogenic role in several types of human cancer, but the status of Bmi-1 amplification and expression in ovarian cancer and its clinical/prognostic significance are unclear.Methods: The methods of immunohistochemistry and fluorescence in situ hybridization were utilized to examine protein expression and amplification of Bmi-1 in 30 normal ovaries, 30 ovarian cystadenomas, 40 borderline ovarian tumors and 179 ovarian carcinomas.Results: Intensive expression of Bmi-1 was detected in none of the normal ovaries, 3% cystadenomas, 10% borderline tumors, and 37% ovarian carcinomas, respectively. Amplification of Bmi-1 was detected in 8% of ovarian carcinomas. In ovarian carcinomas, significant positive associations were found between intensive expression of Bmi-1 and the tumors ascending histological grade, later pT/pN/pM and FIGO stages (P < 0.05). In univariate survival analysis of the ovarian carcinoma cohorts, a significant association of intensive expression of Bmi-1 with shortened patient survival (mean 49.3 months versus 100.3 months, p < 0.001) was demonstrated. Importantly, Bmi-1 expression provided significant independent prognostic parameters in multivariate analysis (p = 0.005).Conclusions: These findings provide evidence that intensive expression of Bmi-1 might be important in the acquisition of an invasive and/or aggressive phenotype of ovarian carcinoma, and serve as a independent biomarker for shortened survival time of patients. © 2010 Yang et al; licensee BioMed Central Ltd.
 
dc.description.naturepublished_or_final_version
 
dc.identifier.citationBmc Cancer, 2010, v. 10 [How to Cite?]
DOI: http://dx.doi.org/10.1186/1471-2407-10-133
 
dc.identifier.citeulike7017250
 
dc.identifier.doihttp://dx.doi.org/10.1186/1471-2407-10-133
 
dc.identifier.hkuros169643
 
dc.identifier.isiWOS:000277008400001
Funding AgencyGrant Number
Major State Basic Research Program of China2006CB910104
Nature Science Foundation of China30772334
Project of Guangdong Science and Technology Agency2004B35001004
2005A30801001
Funding Information:

This study was supported by the grants from the the Major State Basic Research Program of China (2006CB910104), the Nature Science Foundation of China (No. 30772334) and Project of Guangdong Science and Technology Agency (No. 2004B35001004 and 2005A30801001).

 
dc.identifier.issn1471-2407
2012 Impact Factor: 3.333
2012 SCImago Journal Rankings: 1.331
 
dc.identifier.openurl
 
dc.identifier.pmcidPMC2858112
 
dc.identifier.pmid20377880
 
dc.identifier.scopuseid_2-s2.0-77950657234
 
dc.identifier.urihttp://hdl.handle.net/10722/71929
 
dc.identifier.volume10
 
dc.languageeng
 
dc.publisherBioMed Central Ltd. The Journal's web site is located at http://www.biomedcentral.com/bmccancer/
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofBMC Cancer
 
dc.relation.referencesReferences in Scopus
 
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
 
dc.subject.meshNuclear Proteins - biosynthesis - genetics
 
dc.subject.meshOvarian Neoplasms - genetics - metabolism - pathology
 
dc.subject.meshProto-Oncogene Proteins - biosynthesis - genetics
 
dc.subject.meshRepressor Proteins - biosynthesis - genetics
 
dc.subject.meshTumor Markers, Biological - biosynthesis - genetics
 
dc.titleIntensive expression of Bmi-1 is a new independent predictor of poor outcome in patients with ovarian carcinoma
 
dc.typeArticle
 
<?xml encoding="utf-8" version="1.0"?>
<item><contributor.author>Yang, GF</contributor.author>
<contributor.author>He, WP</contributor.author>
<contributor.author>Cai, MY</contributor.author>
<contributor.author>He, LR</contributor.author>
<contributor.author>Luo, JH</contributor.author>
<contributor.author>Deng, HX</contributor.author>
<contributor.author>Guan, XY</contributor.author>
<contributor.author>Zeng, MS</contributor.author>
<contributor.author>Zeng, YX</contributor.author>
<contributor.author>Xie, D</contributor.author>
<date.accessioned>2010-09-06T06:36:36Z</date.accessioned>
<date.available>2010-09-06T06:36:36Z</date.available>
<date.issued>2010</date.issued>
<identifier.citation>Bmc Cancer, 2010, v. 10</identifier.citation>
<identifier.issn>1471-2407</identifier.issn>
<identifier.uri>http://hdl.handle.net/10722/71929</identifier.uri>
<description.abstract>Background: It has been suggested that the B-cell specific moloney leukemia virus insertion site 1 (Bmi-1) gene plays an oncogenic role in several types of human cancer, but the status of Bmi-1 amplification and expression in ovarian cancer and its clinical/prognostic significance are unclear.Methods: The methods of immunohistochemistry and fluorescence in situ hybridization were utilized to examine protein expression and amplification of Bmi-1 in 30 normal ovaries, 30 ovarian cystadenomas, 40 borderline ovarian tumors and 179 ovarian carcinomas.Results: Intensive expression of Bmi-1 was detected in none of the normal ovaries, 3% cystadenomas, 10% borderline tumors, and 37% ovarian carcinomas, respectively. Amplification of Bmi-1 was detected in 8% of ovarian carcinomas. In ovarian carcinomas, significant positive associations were found between intensive expression of Bmi-1 and the tumors ascending histological grade, later pT/pN/pM and FIGO stages (P &lt; 0.05). In univariate survival analysis of the ovarian carcinoma cohorts, a significant association of intensive expression of Bmi-1 with shortened patient survival (mean 49.3 months versus 100.3 months, p &lt; 0.001) was demonstrated. Importantly, Bmi-1 expression provided significant independent prognostic parameters in multivariate analysis (p = 0.005).Conclusions: These findings provide evidence that intensive expression of Bmi-1 might be important in the acquisition of an invasive and/or aggressive phenotype of ovarian carcinoma, and serve as a independent biomarker for shortened survival time of patients. &#169; 2010 Yang et al; licensee BioMed Central Ltd.</description.abstract>
<language>eng</language>
<publisher>BioMed Central Ltd. The Journal&apos;s web site is located at http://www.biomedcentral.com/bmccancer/</publisher>
<relation.ispartof>BMC Cancer</relation.ispartof>
<rights>Creative Commons: Attribution 3.0 Hong Kong License</rights>
<subject.mesh>Nuclear Proteins - biosynthesis - genetics</subject.mesh>
<subject.mesh>Ovarian Neoplasms - genetics - metabolism - pathology</subject.mesh>
<subject.mesh>Proto-Oncogene Proteins - biosynthesis - genetics</subject.mesh>
<subject.mesh>Repressor Proteins - biosynthesis - genetics</subject.mesh>
<subject.mesh>Tumor Markers, Biological - biosynthesis - genetics</subject.mesh>
<title>Intensive expression of Bmi-1 is a new independent predictor of poor outcome in patients with ovarian carcinoma</title>
<type>Article</type>
<identifier.openurl>http://library.hku.hk:4550/resserv?sid=HKU:IR&amp;issn=1471-2407&amp;volume=10 article no. 133&amp;spage=&amp;epage=&amp;date=2010&amp;atitle=Intensive+expression+of+Bmi-1+is+a+new+independent+predictor+of+poor+outcome+in+patients+with+ovarian+carcinoma</identifier.openurl>
<description.nature>published_or_final_version</description.nature>
<identifier.doi>10.1186/1471-2407-10-133</identifier.doi>
<identifier.pmid>20377880</identifier.pmid>
<identifier.pmcid>PMC2858112</identifier.pmcid>
<identifier.scopus>eid_2-s2.0-77950657234</identifier.scopus>
<identifier.hkuros>169643</identifier.hkuros>
<relation.references>http://www.scopus.com/mlt/select.url?eid=2-s2.0-77950657234&amp;selection=ref&amp;src=s&amp;origin=recordpage</relation.references>
<identifier.volume>10</identifier.volume>
<identifier.isi>WOS:000277008400001</identifier.isi>
<publisher.place>United Kingdom</publisher.place>
<identifier.citeulike>7017250</identifier.citeulike>
<bitstream.url>http://hub.hku.hk/bitstream/10722/71929/1/1471-2407-10-133.pdf</bitstream.url>
</item>
Author Affiliations
  1. Sun Yat-Sen University