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Article: Up-regulated expression of cytoplasmic clusterin in human ovarian carcinoma

TitleUp-regulated expression of cytoplasmic clusterin in human ovarian carcinoma
Authors
Issue Date2005
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/28741
Citation
Cancer, 2005, v. 103 n. 2, p. 277-283 How to Cite?
AbstractBACKGROUND. Recently, tumorigenic roles of the clusterin gene in several human malignancies have been suggested, but its potential role in the development and progression of ovarian carcinoma is unclear. METHODS. In the current study, immunohistochemistry was used to examine the expression status of clusterin in 10 normal ovaries, 20 ovarian cystadenomas, 15 borderline ovarian tumors, and 240 ovarian carcinomas (nonmetastatic and metastatic) by tissue microarray. In addition, the apoptotic index of each tumor was assessed with a terminal deoxyuridine triphosphate nick-end labeling assay. RESULTS. Positive staining for clusterin in different ovarian tissues was observed primarily a cytoplasmic pattern. Cytoplasmic overexpression of clusterin was detected in none of the normal ovaries, in 17% of cystadenomas, in 38% of borderline tumors, and in 58% of invasive ovarian carcinomas. A significant association was observed (P < 0.001) between the overexpression of clusterin and late clinical stage according to the International Federation of Gynecology and Obstetrics staging system. In addition, the overexpression of clusterin was detected more frequently in metastatic lesions than that in their matched primary tumors. The current results also provided evidence that the overexpression of cytoplasmic clusterin in carcinomas was correlated inversely with the tumors' apoptotic index, demonstrating an antiapoptotic function of cytoplasmic clusterin in ovarian carcinomas. CONCLUSIONS. The current results suggested that the overexpression of cytoplasmic clusterin may represent an acquired malignant phenotypic feature of ovarian carcinoma and may be one of the important factors in determining the aggressive nature of ovarian carcinoma. © 2004 American Cancer Society.
Persistent Identifierhttp://hdl.handle.net/10722/71928
ISSN
2015 Impact Factor: 5.649
2015 SCImago Journal Rankings: 3.188
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorXie, Den_HK
dc.contributor.authorSze, HLen_HK
dc.contributor.authorSham, JSTen_HK
dc.contributor.authorWu, QLen_HK
dc.contributor.authorFang, Yen_HK
dc.contributor.authorLiang, LZen_HK
dc.contributor.authorChe, LHen_HK
dc.contributor.authorZeng, YXen_HK
dc.contributor.authorGuan, XYen_HK
dc.date.accessioned2010-09-06T06:36:35Z-
dc.date.available2010-09-06T06:36:35Z-
dc.date.issued2005en_HK
dc.identifier.citationCancer, 2005, v. 103 n. 2, p. 277-283en_HK
dc.identifier.issn0008-543Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/71928-
dc.description.abstractBACKGROUND. Recently, tumorigenic roles of the clusterin gene in several human malignancies have been suggested, but its potential role in the development and progression of ovarian carcinoma is unclear. METHODS. In the current study, immunohistochemistry was used to examine the expression status of clusterin in 10 normal ovaries, 20 ovarian cystadenomas, 15 borderline ovarian tumors, and 240 ovarian carcinomas (nonmetastatic and metastatic) by tissue microarray. In addition, the apoptotic index of each tumor was assessed with a terminal deoxyuridine triphosphate nick-end labeling assay. RESULTS. Positive staining for clusterin in different ovarian tissues was observed primarily a cytoplasmic pattern. Cytoplasmic overexpression of clusterin was detected in none of the normal ovaries, in 17% of cystadenomas, in 38% of borderline tumors, and in 58% of invasive ovarian carcinomas. A significant association was observed (P < 0.001) between the overexpression of clusterin and late clinical stage according to the International Federation of Gynecology and Obstetrics staging system. In addition, the overexpression of clusterin was detected more frequently in metastatic lesions than that in their matched primary tumors. The current results also provided evidence that the overexpression of cytoplasmic clusterin in carcinomas was correlated inversely with the tumors' apoptotic index, demonstrating an antiapoptotic function of cytoplasmic clusterin in ovarian carcinomas. CONCLUSIONS. The current results suggested that the overexpression of cytoplasmic clusterin may represent an acquired malignant phenotypic feature of ovarian carcinoma and may be one of the important factors in determining the aggressive nature of ovarian carcinoma. © 2004 American Cancer Society.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/28741en_HK
dc.relation.ispartofCanceren_HK
dc.rightsCancer. Copyright © John Wiley & Sons, Inc.en_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshBiopsy, Needleen_HK
dc.subject.meshCarcinoma - genetics - pathologyen_HK
dc.subject.meshCase-Control Studiesen_HK
dc.subject.meshChi-Square Distributionen_HK
dc.subject.meshClusterinen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGene Expression Regulation, Neoplasticen_HK
dc.subject.meshGlycoproteins - genetics - metabolismen_HK
dc.subject.meshHumansen_HK
dc.subject.meshImmunohistochemistryen_HK
dc.subject.meshIn Situ Nick-End Labelingen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshMolecular Chaperones - genetics - metabolismen_HK
dc.subject.meshNeoplasm Stagingen_HK
dc.subject.meshOvarian Neoplasms - genetics - pathologyen_HK
dc.subject.meshProbabilityen_HK
dc.subject.meshPrognosisen_HK
dc.subject.meshReference Valuesen_HK
dc.subject.meshSensitivity and Specificityen_HK
dc.subject.meshTumor Markers, Biological - analysisen_HK
dc.subject.meshUp-Regulationen_HK
dc.titleUp-regulated expression of cytoplasmic clusterin in human ovarian carcinomaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0008-543X&volume=103&issue=2&spage=277&epage=283&date=2005&atitle=Up-regulated+expression+of+cytoplasmic+clusterin+in+human+ovarian+carcinomaen_HK
dc.identifier.emailGuan, XY:xyguan@hkucc.hku.hken_HK
dc.identifier.authorityGuan, XY=rp00454en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/cncr.20765en_HK
dc.identifier.pmid15578711-
dc.identifier.scopuseid_2-s2.0-12344322308en_HK
dc.identifier.hkuros100393en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-12344322308&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume103en_HK
dc.identifier.issue2en_HK
dc.identifier.spage277en_HK
dc.identifier.epage283en_HK
dc.identifier.isiWOS:000226379000009-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridXie, D=35070710200en_HK
dc.identifier.scopusauthoridSze, HL=16640294000en_HK
dc.identifier.scopusauthoridSham, JST=7101655565en_HK
dc.identifier.scopusauthoridWu, QL=7404602639en_HK
dc.identifier.scopusauthoridFang, Y=7403457405en_HK
dc.identifier.scopusauthoridLiang, LZ=7202069553en_HK
dc.identifier.scopusauthoridChe, LH=7003959690en_HK
dc.identifier.scopusauthoridZeng, YX=7402981579en_HK
dc.identifier.scopusauthoridGuan, XY=7201463221en_HK

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