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Article: Preliminary study of in vivo autofluorescence of nasopharyngeal carcinoma and normal tissue

TitlePreliminary study of in vivo autofluorescence of nasopharyngeal carcinoma and normal tissue
Authors
KeywordsEndoscopy
In vivo diagnosis
LIF spectroscopy
Nasopharyngeal cancer
Issue Date2000
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/34073
Citation
Lasers In Surgery And Medicine, 2000, v. 26 n. 5, p. 432-440 How to Cite?
AbstractBackground and Objective: In nasopharyngeal cancer, conventional white light endoscopy does not provide adequate information to detect the flat/small lesion and identify the margin of observable tumor. In the present study, we evaluate the potential of light-induced fluorescence spectroscopic imaging for the localization of cancerous nasopharyngeal tissue. Study Design/Materials and Methods: We built a multiple channel spectrometer specifically for the investigation of fluorescence collected by a conventional endoscopic system. Nasopharyngeal fluorescence were measured in vivo from 27 subjects during the routine endoscopy. The biopsy specimens for histologic analysis were taken from the tissue sites where the fluorescence were measured. Results: Two algorithms to discriminate the nasopharyngeal carcinoma from normal tissue were created based on the good correlation between the tissue autofluorescence and histologic diagnosis. For the two- wavelength algorithm, carcinoma can be differentiated from normal tissue with a sensitivity and specificity of 93% and 92%, respectively. For the three- wavelength algorithm with compensation of variation of blood content in tissue, a sensitivity of 98% and specificity of 95% were achieved. Conclusion: Fluorescence endoscopic imaging used with the algorithms developed in this report is an efficient method for detecting the nasopharyngeal carcinoma. (C) 2000 Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/71926
ISSN
2015 Impact Factor: 2.135
2015 SCImago Journal Rankings: 0.977
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorQu, JYen_HK
dc.contributor.authorWing, Pen_HK
dc.contributor.authorHuang, Zen_HK
dc.contributor.authorKwong, Den_HK
dc.contributor.authorSham, Jen_HK
dc.contributor.authorLee, SLen_HK
dc.contributor.authorHo, WKen_HK
dc.contributor.authorWei, WIen_HK
dc.date.accessioned2010-09-06T06:36:34Z-
dc.date.available2010-09-06T06:36:34Z-
dc.date.issued2000en_HK
dc.identifier.citationLasers In Surgery And Medicine, 2000, v. 26 n. 5, p. 432-440en_HK
dc.identifier.issn0196-8092en_HK
dc.identifier.urihttp://hdl.handle.net/10722/71926-
dc.description.abstractBackground and Objective: In nasopharyngeal cancer, conventional white light endoscopy does not provide adequate information to detect the flat/small lesion and identify the margin of observable tumor. In the present study, we evaluate the potential of light-induced fluorescence spectroscopic imaging for the localization of cancerous nasopharyngeal tissue. Study Design/Materials and Methods: We built a multiple channel spectrometer specifically for the investigation of fluorescence collected by a conventional endoscopic system. Nasopharyngeal fluorescence were measured in vivo from 27 subjects during the routine endoscopy. The biopsy specimens for histologic analysis were taken from the tissue sites where the fluorescence were measured. Results: Two algorithms to discriminate the nasopharyngeal carcinoma from normal tissue were created based on the good correlation between the tissue autofluorescence and histologic diagnosis. For the two- wavelength algorithm, carcinoma can be differentiated from normal tissue with a sensitivity and specificity of 93% and 92%, respectively. For the three- wavelength algorithm with compensation of variation of blood content in tissue, a sensitivity of 98% and specificity of 95% were achieved. Conclusion: Fluorescence endoscopic imaging used with the algorithms developed in this report is an efficient method for detecting the nasopharyngeal carcinoma. (C) 2000 Wiley-Liss, Inc.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/34073en_HK
dc.relation.ispartofLasers in Surgery and Medicineen_HK
dc.rightsLasers in Surgery and Medicine. Copyright © John Wiley & Sons, Inc.en_HK
dc.subjectEndoscopyen_HK
dc.subjectIn vivo diagnosisen_HK
dc.subjectLIF spectroscopyen_HK
dc.subjectNasopharyngeal canceren_HK
dc.subject.meshAlgorithmsen_HK
dc.subject.meshCarcinoma - diagnosis - physiopathologyen_HK
dc.subject.meshEndoscopy - methodsen_HK
dc.subject.meshHumansen_HK
dc.subject.meshNasopharyngeal Neoplasms - diagnosis - physiopathologyen_HK
dc.subject.meshNasopharynx - physiologyen_HK
dc.subject.meshSensitivity and Specificityen_HK
dc.subject.meshSpectrometry, Fluorescence - instrumentation - methodsen_HK
dc.titlePreliminary study of in vivo autofluorescence of nasopharyngeal carcinoma and normal tissueen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0196-8092&volume=26&spage=432&epage=440&date=2000&atitle=Preliminary+study+of+in+vivo+autofluorescence+of+nasopharyngeal+carcinoma+and+normal+tissueen_HK
dc.identifier.emailKwong, D: dlwkwong@hku.hken_HK
dc.identifier.emailWei, WI: hrmswwi@hku.hken_HK
dc.identifier.authorityKwong, D=rp00414en_HK
dc.identifier.authorityWei, WI=rp00323en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/1096-9101(2000)26:5<432::AID-LSM2>3.0.CO;2-1en_HK
dc.identifier.pmid10861698-
dc.identifier.scopuseid_2-s2.0-0033931289en_HK
dc.identifier.hkuros52437en_HK
dc.identifier.hkuros108522-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033931289&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume26en_HK
dc.identifier.issue5en_HK
dc.identifier.spage432en_HK
dc.identifier.epage440en_HK
dc.identifier.isiWOS:000087754900002-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridQu, JY=7201534954en_HK
dc.identifier.scopusauthoridWing, P=7005813469en_HK
dc.identifier.scopusauthoridHuang, Z=26662208200en_HK
dc.identifier.scopusauthoridKwong, D=15744231600en_HK
dc.identifier.scopusauthoridSham, J=24472255400en_HK
dc.identifier.scopusauthoridLee, SL=8369148500en_HK
dc.identifier.scopusauthoridHo, WK=7402968844en_HK
dc.identifier.scopusauthoridWei, WI=7403321552en_HK

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