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Article: The significance of LMO2 expression in the progression of prostate cancer

TitleThe significance of LMO2 expression in the progression of prostate cancer
Authors
KeywordsE-cadherin
LMO2
Metastasis
Prostate cancer
Issue Date2007
PublisherJohn Wiley & Sons. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/1130
Citation
Journal Of Pathology, 2007, v. 211 n. 3, p. 278-285 How to Cite?
AbstractLIM domain only 2 (LMO2) proteins are important regulators in determining cell fate and controlling cell growth and differentiation. This study has investigated LMO2 expression in human prostatic tissue specimens, prostate cancer cell lines, and xenografts; and has assessed the possible role and mechanism of LMO2 in prostate carcinogenesis. Immunohistochemical analysis on a tissue microarray consisting of 91 human prostate specimens, including normal, prostatic hyperplasia, high-grade prostatic intraepithelial neoplasia, and invasive carcinoma, revealed that overexpression of LMO2 was significantly associated with advanced tumour stage, as measured by Gleason score (p = 0.012), as well as with the development of distant metastasis (p = 0.018). These data were supported by quantitative real-time PCR experiments, where LMO2 mRNA levels were found to be significantly higher in prostate tumour specimen than in normal epithelium (p = 0.037). The expression of LMO2 in cell lines and xenografts representing androgen-dependent (AD) and androgen-independent (AI) prostate cancer stages was further studied. Consistent with the in vivo data, LMO2 mRNA and protein were found to be overexpressed in the more aggressive AI cells (PC3, DU145, and AI CWR22 xenografts) compared with less aggressive AD cells (LNCaP and AD CWR22 xenografts). Furthermore, stable introduction of LMO2 into LNCaP cells conferred enhanced cell motility and invasiveness in vitro, accompanied by down-regulation of E-cadherin expression. Taken together, these findings provide the first evidence to support the hvpothesis that LMO2 may play an important role in prostate cancer progression, possibly via repression of E-cadherin expression. Copyright © 2006 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/71925
ISSN
2015 Impact Factor: 7.381
2015 SCImago Journal Rankings: 4.176
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMa, Sen_HK
dc.contributor.authorGuan, XYen_HK
dc.contributor.authorBeh, PSLen_HK
dc.contributor.authorWong, KYen_HK
dc.contributor.authorChan, YPen_HK
dc.contributor.authorYuen, HFen_HK
dc.contributor.authorVielkind, Jen_HK
dc.contributor.authorChan, KWen_HK
dc.date.accessioned2010-09-06T06:36:33Z-
dc.date.available2010-09-06T06:36:33Z-
dc.date.issued2007en_HK
dc.identifier.citationJournal Of Pathology, 2007, v. 211 n. 3, p. 278-285en_HK
dc.identifier.issn0022-3417en_HK
dc.identifier.urihttp://hdl.handle.net/10722/71925-
dc.description.abstractLIM domain only 2 (LMO2) proteins are important regulators in determining cell fate and controlling cell growth and differentiation. This study has investigated LMO2 expression in human prostatic tissue specimens, prostate cancer cell lines, and xenografts; and has assessed the possible role and mechanism of LMO2 in prostate carcinogenesis. Immunohistochemical analysis on a tissue microarray consisting of 91 human prostate specimens, including normal, prostatic hyperplasia, high-grade prostatic intraepithelial neoplasia, and invasive carcinoma, revealed that overexpression of LMO2 was significantly associated with advanced tumour stage, as measured by Gleason score (p = 0.012), as well as with the development of distant metastasis (p = 0.018). These data were supported by quantitative real-time PCR experiments, where LMO2 mRNA levels were found to be significantly higher in prostate tumour specimen than in normal epithelium (p = 0.037). The expression of LMO2 in cell lines and xenografts representing androgen-dependent (AD) and androgen-independent (AI) prostate cancer stages was further studied. Consistent with the in vivo data, LMO2 mRNA and protein were found to be overexpressed in the more aggressive AI cells (PC3, DU145, and AI CWR22 xenografts) compared with less aggressive AD cells (LNCaP and AD CWR22 xenografts). Furthermore, stable introduction of LMO2 into LNCaP cells conferred enhanced cell motility and invasiveness in vitro, accompanied by down-regulation of E-cadherin expression. Taken together, these findings provide the first evidence to support the hvpothesis that LMO2 may play an important role in prostate cancer progression, possibly via repression of E-cadherin expression. Copyright © 2006 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/1130en_HK
dc.relation.ispartofJournal of Pathologyen_HK
dc.rightsJournal of Pathology. Copyright © John Wiley & Sons Ltd.en_HK
dc.subjectE-cadherinen_HK
dc.subjectLMO2en_HK
dc.subjectMetastasisen_HK
dc.subjectProstate canceren_HK
dc.subject.meshAdaptor Proteins, Signal Transducingen_HK
dc.subject.meshAdenocarcinoma - pathologyen_HK
dc.subject.meshAgeden_HK
dc.subject.meshAged, 80 and overen_HK
dc.subject.meshBlotting, Western - methodsen_HK
dc.subject.meshCell Line, Tumoren_HK
dc.subject.meshChi-Square Distributionen_HK
dc.subject.meshDNA-Binding Proteins - geneticsen_HK
dc.subject.meshGene Expression Profilingen_HK
dc.subject.meshGene Expression Regulation, Neoplasticen_HK
dc.subject.meshHumansen_HK
dc.subject.meshImmunohistochemistry - methodsen_HK
dc.subject.meshLIM Domain Proteinsen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMetalloproteins - geneticsen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshNeoplasm Stagingen_HK
dc.subject.meshOligonucleotide Array Sequence Analysisen_HK
dc.subject.meshPrognosisen_HK
dc.subject.meshProstatic Neoplasms - pathologyen_HK
dc.subject.meshProto-Oncogene Proteinsen_HK
dc.subject.meshRNA, Messenger - analysisen_HK
dc.subject.meshReverse Transcriptase Polymerase Chain Reactionen_HK
dc.titleThe significance of LMO2 expression in the progression of prostate canceren_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-3417&volume=211&issue=3&spage=278&epage=85&date=2007&atitle=The+significance+of+LMO2+expression+in+the+progression+of+prostate+canceren_HK
dc.identifier.emailMa, S:sma@pathology.hku.hken_HK
dc.identifier.emailGuan, XY:xyguan@hkucc.hku.hken_HK
dc.identifier.emailBeh, PSL:philipbeh@pathology.hku.hken_HK
dc.identifier.emailChan, KW:hrmtckw@hku.hken_HK
dc.identifier.authorityMa, S=rp00506en_HK
dc.identifier.authorityGuan, XY=rp00454en_HK
dc.identifier.authorityBeh, PSL=rp00409en_HK
dc.identifier.authorityChan, KW=rp00330en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/path.2109en_HK
dc.identifier.pmid17167821en_HK
dc.identifier.scopuseid_2-s2.0-33846563501en_HK
dc.identifier.hkuros140888en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33846563501&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume211en_HK
dc.identifier.issue3en_HK
dc.identifier.spage278en_HK
dc.identifier.epage285en_HK
dc.identifier.eissn1096-9896-
dc.identifier.isiWOS:000244237800003-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridMa, S=16444895800en_HK
dc.identifier.scopusauthoridGuan, XY=7201463221en_HK
dc.identifier.scopusauthoridBeh, PSL=6603146797en_HK
dc.identifier.scopusauthoridWong, KY=7404758500en_HK
dc.identifier.scopusauthoridChan, YP=14009821700en_HK
dc.identifier.scopusauthoridYuen, HF=14018633400en_HK
dc.identifier.scopusauthoridVielkind, J=7004097540en_HK
dc.identifier.scopusauthoridChan, KW=16444133100en_HK

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