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Article: White matter anisotropy in childhood medulloblastoma survivors: Association with neurotoxicity risk factors
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TitleWhite matter anisotropy in childhood medulloblastoma survivors: Association with neurotoxicity risk factors
 
AuthorsKhong, PL1
Leung, LHT1
Chan, GCF1
Kwong, DLW1
Wong, WHS1
Cao, G2
Ooi, GC1
 
Issue Date2005
 
PublisherRadiological Society of North America, Inc. The Journal's web site is located at http://radiology.rsnajnls.org
 
CitationRadiology, 2005, v. 236 n. 2, p. 647-652 [How to Cite?]
DOI: http://dx.doi.org/10.1148/radiol.2362041066
 
AbstractPURPOSE: To prospectively evaluate the relationships between change in white matter (WM) anisotropy and (a) patient age at craniospinal irradiation (CSI), (b) CSI dose, and (c) time of magnetic resonance (MR) imaging since CSI and to determine the effect of these neurotoxicity risk factors on WM anisotropy in posttreatment medulloblastoma survivors. MATERIALS AND METHODS: Informed consent was obtained from the patients, control subjects, or their parents, and the study was approved by the institutional review board. Twenty consecutive medulloblastoma survivors (14 male, six female; mean age, 11.0 years ± 4.6 [standard deviation]) and 36 control subjects (14 male, 22 female; mean age, 10.7 years ± 3.5) were examined. Control subjects were divided into four groups according to age: 5.0-7.9 years, 8.0-10.9 years, 11.0-13.9 years, and 14.0-18.9 years. The authors calculated the histogram-derived mean WM fractional anisotropy (FA) value for each patient and compared it with the mean WM FA value for the control subjects in the corresponding age group to evaluate the percentage change in WM FA (ΔFA) in each patient. Spearman rank correlation analysis was used to analyze the relationships between ΔFA and (a) age at CSI, (b) CSI dose, and (c) time of MR imaging since CSI. Then, multiple linear regression analysis was performed to study the simultaneous influence of these factors on ΔFA. RESULTS: There were significant correlations between ΔFA and both age at CSI (r = 0.631, P = .003) and CSI dose (r = -0.586, P = .007) but not between ΔFA and time of MR imaging since CSI. Multiple linear regression analysis revealed age at CSI to be the only independent variable that significantly affected ΔFA (adjusted r 2 = 0.391, P = .012). CONCLUSION: Loss of WM anisotropy is significantly affected by age at CSI, and there is a trend toward increasing anisotropy loss with larger CSI dose. Both age at CSI and CSI dose are known risk factors of neurotoxicity. © RSNA, 2005.
 
ISSN0033-8419
2013 Impact Factor: 6.214
 
DOIhttp://dx.doi.org/10.1148/radiol.2362041066
 
ISI Accession Number IDWOS:000230670200038
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorKhong, PL
 
dc.contributor.authorLeung, LHT
 
dc.contributor.authorChan, GCF
 
dc.contributor.authorKwong, DLW
 
dc.contributor.authorWong, WHS
 
dc.contributor.authorCao, G
 
dc.contributor.authorOoi, GC
 
dc.date.accessioned2010-09-06T06:36:32Z
 
dc.date.available2010-09-06T06:36:32Z
 
dc.date.issued2005
 
dc.description.abstractPURPOSE: To prospectively evaluate the relationships between change in white matter (WM) anisotropy and (a) patient age at craniospinal irradiation (CSI), (b) CSI dose, and (c) time of magnetic resonance (MR) imaging since CSI and to determine the effect of these neurotoxicity risk factors on WM anisotropy in posttreatment medulloblastoma survivors. MATERIALS AND METHODS: Informed consent was obtained from the patients, control subjects, or their parents, and the study was approved by the institutional review board. Twenty consecutive medulloblastoma survivors (14 male, six female; mean age, 11.0 years ± 4.6 [standard deviation]) and 36 control subjects (14 male, 22 female; mean age, 10.7 years ± 3.5) were examined. Control subjects were divided into four groups according to age: 5.0-7.9 years, 8.0-10.9 years, 11.0-13.9 years, and 14.0-18.9 years. The authors calculated the histogram-derived mean WM fractional anisotropy (FA) value for each patient and compared it with the mean WM FA value for the control subjects in the corresponding age group to evaluate the percentage change in WM FA (ΔFA) in each patient. Spearman rank correlation analysis was used to analyze the relationships between ΔFA and (a) age at CSI, (b) CSI dose, and (c) time of MR imaging since CSI. Then, multiple linear regression analysis was performed to study the simultaneous influence of these factors on ΔFA. RESULTS: There were significant correlations between ΔFA and both age at CSI (r = 0.631, P = .003) and CSI dose (r = -0.586, P = .007) but not between ΔFA and time of MR imaging since CSI. Multiple linear regression analysis revealed age at CSI to be the only independent variable that significantly affected ΔFA (adjusted r 2 = 0.391, P = .012). CONCLUSION: Loss of WM anisotropy is significantly affected by age at CSI, and there is a trend toward increasing anisotropy loss with larger CSI dose. Both age at CSI and CSI dose are known risk factors of neurotoxicity. © RSNA, 2005.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationRadiology, 2005, v. 236 n. 2, p. 647-652 [How to Cite?]
DOI: http://dx.doi.org/10.1148/radiol.2362041066
 
dc.identifier.doihttp://dx.doi.org/10.1148/radiol.2362041066
 
dc.identifier.epage652
 
dc.identifier.hkuros100349
 
dc.identifier.isiWOS:000230670200038
 
dc.identifier.issn0033-8419
2013 Impact Factor: 6.214
 
dc.identifier.issue2
 
dc.identifier.openurl
 
dc.identifier.pmid16040920
 
dc.identifier.scopuseid_2-s2.0-22544444501
 
dc.identifier.spage647
 
dc.identifier.urihttp://hdl.handle.net/10722/71923
 
dc.identifier.volume236
 
dc.languageeng
 
dc.publisherRadiological Society of North America, Inc. The Journal's web site is located at http://radiology.rsnajnls.org
 
dc.publisher.placeUnited States
 
dc.relation.ispartofRadiology
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAdolescent
 
dc.subject.meshAnisotropy
 
dc.subject.meshCerebellar Neoplasms - pathology
 
dc.subject.meshChild
 
dc.subject.meshChild, Preschool
 
dc.subject.meshFemale
 
dc.subject.meshHumans
 
dc.subject.meshMagnetic Resonance Imaging
 
dc.subject.meshMale
 
dc.subject.meshMedulloblastoma - pathology
 
dc.subject.meshNeurotoxicity Syndromes
 
dc.subject.meshProspective Studies
 
dc.subject.meshRisk Factors
 
dc.subject.meshSurvivors
 
dc.titleWhite matter anisotropy in childhood medulloblastoma survivors: Association with neurotoxicity risk factors
 
dc.typeArticle
 
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<contributor.author>Leung, LHT</contributor.author>
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<contributor.author>Kwong, DLW</contributor.author>
<contributor.author>Wong, WHS</contributor.author>
<contributor.author>Cao, G</contributor.author>
<contributor.author>Ooi, GC</contributor.author>
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<description.abstract>PURPOSE: To prospectively evaluate the relationships between change in white matter (WM) anisotropy and (a) patient age at craniospinal irradiation (CSI), (b) CSI dose, and (c) time of magnetic resonance (MR) imaging since CSI and to determine the effect of these neurotoxicity risk factors on WM anisotropy in posttreatment medulloblastoma survivors. MATERIALS AND METHODS: Informed consent was obtained from the patients, control subjects, or their parents, and the study was approved by the institutional review board. Twenty consecutive medulloblastoma survivors (14 male, six female; mean age, 11.0 years &#177; 4.6 [standard deviation]) and 36 control subjects (14 male, 22 female; mean age, 10.7 years &#177; 3.5) were examined. Control subjects were divided into four groups according to age: 5.0-7.9 years, 8.0-10.9 years, 11.0-13.9 years, and 14.0-18.9 years. The authors calculated the histogram-derived mean WM fractional anisotropy (FA) value for each patient and compared it with the mean WM FA value for the control subjects in the corresponding age group to evaluate the percentage change in WM FA (&#916;FA) in each patient. Spearman rank correlation analysis was used to analyze the relationships between &#916;FA and (a) age at CSI, (b) CSI dose, and (c) time of MR imaging since CSI. Then, multiple linear regression analysis was performed to study the simultaneous influence of these factors on &#916;FA. RESULTS: There were significant correlations between &#916;FA and both age at CSI (r = 0.631, P = .003) and CSI dose (r = -0.586, P = .007) but not between &#916;FA and time of MR imaging since CSI. Multiple linear regression analysis revealed age at CSI to be the only independent variable that significantly affected &#916;FA (adjusted r 2 = 0.391, P = .012). CONCLUSION: Loss of WM anisotropy is significantly affected by age at CSI, and there is a trend toward increasing anisotropy loss with larger CSI dose. Both age at CSI and CSI dose are known risk factors of neurotoxicity. &#169; RSNA, 2005.</description.abstract>
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Author Affiliations
  1. The University of Hong Kong
  2. GE Medical System Asia