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Article: White matter anisotropy in childhood medulloblastoma survivors: Association with neurotoxicity risk factors

TitleWhite matter anisotropy in childhood medulloblastoma survivors: Association with neurotoxicity risk factors
Authors
Issue Date2005
PublisherRadiological Society of North America, Inc. The Journal's web site is located at http://radiology.rsnajnls.org
Citation
Radiology, 2005, v. 236 n. 2, p. 647-652 How to Cite?
AbstractPURPOSE: To prospectively evaluate the relationships between change in white matter (WM) anisotropy and (a) patient age at craniospinal irradiation (CSI), (b) CSI dose, and (c) time of magnetic resonance (MR) imaging since CSI and to determine the effect of these neurotoxicity risk factors on WM anisotropy in posttreatment medulloblastoma survivors. MATERIALS AND METHODS: Informed consent was obtained from the patients, control subjects, or their parents, and the study was approved by the institutional review board. Twenty consecutive medulloblastoma survivors (14 male, six female; mean age, 11.0 years ± 4.6 [standard deviation]) and 36 control subjects (14 male, 22 female; mean age, 10.7 years ± 3.5) were examined. Control subjects were divided into four groups according to age: 5.0-7.9 years, 8.0-10.9 years, 11.0-13.9 years, and 14.0-18.9 years. The authors calculated the histogram-derived mean WM fractional anisotropy (FA) value for each patient and compared it with the mean WM FA value for the control subjects in the corresponding age group to evaluate the percentage change in WM FA (ΔFA) in each patient. Spearman rank correlation analysis was used to analyze the relationships between ΔFA and (a) age at CSI, (b) CSI dose, and (c) time of MR imaging since CSI. Then, multiple linear regression analysis was performed to study the simultaneous influence of these factors on ΔFA. RESULTS: There were significant correlations between ΔFA and both age at CSI (r = 0.631, P = .003) and CSI dose (r = -0.586, P = .007) but not between ΔFA and time of MR imaging since CSI. Multiple linear regression analysis revealed age at CSI to be the only independent variable that significantly affected ΔFA (adjusted r 2 = 0.391, P = .012). CONCLUSION: Loss of WM anisotropy is significantly affected by age at CSI, and there is a trend toward increasing anisotropy loss with larger CSI dose. Both age at CSI and CSI dose are known risk factors of neurotoxicity. © RSNA, 2005.
Persistent Identifierhttp://hdl.handle.net/10722/71923
ISSN
2015 Impact Factor: 6.798
2015 SCImago Journal Rankings: 3.414
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorKhong, PLen_HK
dc.contributor.authorLeung, LHTen_HK
dc.contributor.authorChan, GCFen_HK
dc.contributor.authorKwong, DLWen_HK
dc.contributor.authorWong, WHSen_HK
dc.contributor.authorCao, Gen_HK
dc.contributor.authorOoi, GCen_HK
dc.date.accessioned2010-09-06T06:36:32Z-
dc.date.available2010-09-06T06:36:32Z-
dc.date.issued2005en_HK
dc.identifier.citationRadiology, 2005, v. 236 n. 2, p. 647-652en_HK
dc.identifier.issn0033-8419en_HK
dc.identifier.urihttp://hdl.handle.net/10722/71923-
dc.description.abstractPURPOSE: To prospectively evaluate the relationships between change in white matter (WM) anisotropy and (a) patient age at craniospinal irradiation (CSI), (b) CSI dose, and (c) time of magnetic resonance (MR) imaging since CSI and to determine the effect of these neurotoxicity risk factors on WM anisotropy in posttreatment medulloblastoma survivors. MATERIALS AND METHODS: Informed consent was obtained from the patients, control subjects, or their parents, and the study was approved by the institutional review board. Twenty consecutive medulloblastoma survivors (14 male, six female; mean age, 11.0 years ± 4.6 [standard deviation]) and 36 control subjects (14 male, 22 female; mean age, 10.7 years ± 3.5) were examined. Control subjects were divided into four groups according to age: 5.0-7.9 years, 8.0-10.9 years, 11.0-13.9 years, and 14.0-18.9 years. The authors calculated the histogram-derived mean WM fractional anisotropy (FA) value for each patient and compared it with the mean WM FA value for the control subjects in the corresponding age group to evaluate the percentage change in WM FA (ΔFA) in each patient. Spearman rank correlation analysis was used to analyze the relationships between ΔFA and (a) age at CSI, (b) CSI dose, and (c) time of MR imaging since CSI. Then, multiple linear regression analysis was performed to study the simultaneous influence of these factors on ΔFA. RESULTS: There were significant correlations between ΔFA and both age at CSI (r = 0.631, P = .003) and CSI dose (r = -0.586, P = .007) but not between ΔFA and time of MR imaging since CSI. Multiple linear regression analysis revealed age at CSI to be the only independent variable that significantly affected ΔFA (adjusted r 2 = 0.391, P = .012). CONCLUSION: Loss of WM anisotropy is significantly affected by age at CSI, and there is a trend toward increasing anisotropy loss with larger CSI dose. Both age at CSI and CSI dose are known risk factors of neurotoxicity. © RSNA, 2005.en_HK
dc.languageengen_HK
dc.publisherRadiological Society of North America, Inc. The Journal's web site is located at http://radiology.rsnajnls.orgen_HK
dc.relation.ispartofRadiologyen_HK
dc.subject.meshAdolescenten_HK
dc.subject.meshAnisotropyen_HK
dc.subject.meshCerebellar Neoplasms - pathologyen_HK
dc.subject.meshChilden_HK
dc.subject.meshChild, Preschoolen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMagnetic Resonance Imagingen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMedulloblastoma - pathologyen_HK
dc.subject.meshNeurotoxicity Syndromesen_HK
dc.subject.meshProspective Studiesen_HK
dc.subject.meshRisk Factorsen_HK
dc.subject.meshSurvivorsen_HK
dc.titleWhite matter anisotropy in childhood medulloblastoma survivors: Association with neurotoxicity risk factorsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0033-8419&volume=236&spage=647&epage=652&date=2005&atitle=White+matter+anisotropy+in+childhood+medulloblastoma+survivors:+association+with+neurotoxicity+risk+factorsen_HK
dc.identifier.emailKhong, PL:plkhong@hkucc.hku.hken_HK
dc.identifier.emailChan, GCF:gcfchan@hkucc.hku.hken_HK
dc.identifier.emailKwong, DLW:dlwkwong@hku.hken_HK
dc.identifier.authorityKhong, PL=rp00467en_HK
dc.identifier.authorityChan, GCF=rp00431en_HK
dc.identifier.authorityKwong, DLW=rp00414en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1148/radiol.2362041066en_HK
dc.identifier.pmid16040920-
dc.identifier.scopuseid_2-s2.0-22544444501en_HK
dc.identifier.hkuros100349en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-22544444501&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume236en_HK
dc.identifier.issue2en_HK
dc.identifier.spage647en_HK
dc.identifier.epage652en_HK
dc.identifier.isiWOS:000230670200038-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridKhong, PL=7006693233en_HK
dc.identifier.scopusauthoridLeung, LHT=7202048113en_HK
dc.identifier.scopusauthoridChan, GCF=16160154400en_HK
dc.identifier.scopusauthoridKwong, DLW=15744231600en_HK
dc.identifier.scopusauthoridWong, WHS=13310222200en_HK
dc.identifier.scopusauthoridCao, G=12776387400en_HK
dc.identifier.scopusauthoridOoi, GC=16239781100en_HK

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