Article: White matter anisotropy in childhood medulloblastoma survivors: Association with neurotoxicity risk factors

File Download Links for fulltext
(May Require Subscription)
  • Basic View
  • Metadata View
  • XML View
TitleWhite matter anisotropy in childhood medulloblastoma survivors: Association with neurotoxicity risk factors
AuthorsKhong, PL1
Leung, LHT1
Chan, GCF1
Kwong, DLW1
Wong, WHS1
Cao, G2
Ooi, GC1
Issue Date2005
PublisherRadiological Society of North America, Inc. The Journal's web site is located at http://radiology.rsnajnls.org
CitationRadiology, 2005, v. 236 n. 2, p. 647-652 [How to Cite?]
DOI: http://dx.doi.org/10.1148/radiol.2362041066
AbstractPURPOSE: To prospectively evaluate the relationships between change in white matter (WM) anisotropy and (a) patient age at craniospinal irradiation (CSI), (b) CSI dose, and (c) time of magnetic resonance (MR) imaging since CSI and to determine the effect of these neurotoxicity risk factors on WM anisotropy in posttreatment medulloblastoma survivors. MATERIALS AND METHODS: Informed consent was obtained from the patients, control subjects, or their parents, and the study was approved by the institutional review board. Twenty consecutive medulloblastoma survivors (14 male, six female; mean age, 11.0 years ± 4.6 [standard deviation]) and 36 control subjects (14 male, 22 female; mean age, 10.7 years ± 3.5) were examined. Control subjects were divided into four groups according to age: 5.0-7.9 years, 8.0-10.9 years, 11.0-13.9 years, and 14.0-18.9 years. The authors calculated the histogram-derived mean WM fractional anisotropy (FA) value for each patient and compared it with the mean WM FA value for the control subjects in the corresponding age group to evaluate the percentage change in WM FA (ΔFA) in each patient. Spearman rank correlation analysis was used to analyze the relationships between ΔFA and (a) age at CSI, (b) CSI dose, and (c) time of MR imaging since CSI. Then, multiple linear regression analysis was performed to study the simultaneous influence of these factors on ΔFA. RESULTS: There were significant correlations between ΔFA and both age at CSI (r = 0.631, P = .003) and CSI dose (r = -0.586, P = .007) but not between ΔFA and time of MR imaging since CSI. Multiple linear regression analysis revealed age at CSI to be the only independent variable that significantly affected ΔFA (adjusted r 2 = 0.391, P = .012). CONCLUSION: Loss of WM anisotropy is significantly affected by age at CSI, and there is a trend toward increasing anisotropy loss with larger CSI dose. Both age at CSI and CSI dose are known risk factors of neurotoxicity. © RSNA, 2005.
ISSN0033-8419
2011 Impact Factor: 5.726
2011 SCImago Journal Rankings: 0.475
DOIhttp://dx.doi.org/10.1148/radiol.2362041066
ISI Accession Number IDWOS:000230670200038
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorKhong, PL
dc.contributor.authorLeung, LHT
dc.contributor.authorChan, GCF
dc.contributor.authorKwong, DLW
dc.contributor.authorWong, WHS
dc.contributor.authorCao, G
dc.contributor.authorOoi, GC
dc.date.accessioned2010-09-06T06:36:32Z
dc.date.available2010-09-06T06:36:32Z
dc.date.issued2005
dc.description.abstractPURPOSE: To prospectively evaluate the relationships between change in white matter (WM) anisotropy and (a) patient age at craniospinal irradiation (CSI), (b) CSI dose, and (c) time of magnetic resonance (MR) imaging since CSI and to determine the effect of these neurotoxicity risk factors on WM anisotropy in posttreatment medulloblastoma survivors. MATERIALS AND METHODS: Informed consent was obtained from the patients, control subjects, or their parents, and the study was approved by the institutional review board. Twenty consecutive medulloblastoma survivors (14 male, six female; mean age, 11.0 years ± 4.6 [standard deviation]) and 36 control subjects (14 male, 22 female; mean age, 10.7 years ± 3.5) were examined. Control subjects were divided into four groups according to age: 5.0-7.9 years, 8.0-10.9 years, 11.0-13.9 years, and 14.0-18.9 years. The authors calculated the histogram-derived mean WM fractional anisotropy (FA) value for each patient and compared it with the mean WM FA value for the control subjects in the corresponding age group to evaluate the percentage change in WM FA (ΔFA) in each patient. Spearman rank correlation analysis was used to analyze the relationships between ΔFA and (a) age at CSI, (b) CSI dose, and (c) time of MR imaging since CSI. Then, multiple linear regression analysis was performed to study the simultaneous influence of these factors on ΔFA. RESULTS: There were significant correlations between ΔFA and both age at CSI (r = 0.631, P = .003) and CSI dose (r = -0.586, P = .007) but not between ΔFA and time of MR imaging since CSI. Multiple linear regression analysis revealed age at CSI to be the only independent variable that significantly affected ΔFA (adjusted r 2 = 0.391, P = .012). CONCLUSION: Loss of WM anisotropy is significantly affected by age at CSI, and there is a trend toward increasing anisotropy loss with larger CSI dose. Both age at CSI and CSI dose are known risk factors of neurotoxicity. © RSNA, 2005.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationRadiology, 2005, v. 236 n. 2, p. 647-652 [How to Cite?]
DOI: http://dx.doi.org/10.1148/radiol.2362041066
dc.identifier.doihttp://dx.doi.org/10.1148/radiol.2362041066
dc.identifier.epage652
dc.identifier.hkuros100349
dc.identifier.isiWOS:000230670200038
dc.identifier.issn0033-8419
2011 Impact Factor: 5.726
2011 SCImago Journal Rankings: 0.475
dc.identifier.issue2
dc.identifier.openurl
dc.identifier.pmid16040920
dc.identifier.scopuseid_2-s2.0-22544444501
dc.identifier.spage647
dc.identifier.urihttp://hdl.handle.net/10722/71923
dc.identifier.volume236
dc.languageeng
dc.publisherRadiological Society of North America, Inc. The Journal's web site is located at http://radiology.rsnajnls.org
dc.publisher.placeUnited States
dc.relation.ispartofRadiology
dc.relation.referencesReferences in Scopus
dc.subject.meshAdolescent
dc.subject.meshAnisotropy
dc.subject.meshCerebellar Neoplasms - pathology
dc.subject.meshChild
dc.subject.meshChild, Preschool
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshMagnetic Resonance Imaging
dc.subject.meshMale
dc.subject.meshMedulloblastoma - pathology
dc.subject.meshNeurotoxicity Syndromes
dc.subject.meshProspective Studies
dc.subject.meshRisk Factors
dc.subject.meshSurvivors
dc.titleWhite matter anisotropy in childhood medulloblastoma survivors: Association with neurotoxicity risk factors
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong
  2. GE Medical System Asia