Article: Recurrent Chromosomal Imbalances in Nonsmall Cell Lung Carcinoma: The Association between 1q Amplification and Tumor Recurrence

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TitleRecurrent Chromosomal Imbalances in Nonsmall Cell Lung Carcinoma: The Association between 1q Amplification and Tumor Recurrence
AuthorsTai, ALS1
Yan, WS2
Fang, Y2
Xie, D1
Sham, JST1
Guan, XY1
Issue Date2004
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/28741
CitationCancer, 2004, v. 100 n. 9, p. 1918-1927 [How to Cite?]
DOI: http://dx.doi.org/10.1002/cncr.20190
AbstractBACKGROUND. Lung carcinoma is a leading cause of cancer deaths worldwide. To better understand this disease, the authors studied genetic alterations in nonsmall cell lung carcinoma (NSCLC) and the association between genetic changes and clinical features. METHODS. Genetic alterations in 30 patients with adenocarcinoma (AC) and 39 patients with squamous cell carcinoma (SCC) were analyzed by comparative genomic hybridization. The genetic changes in patients with AC and SCC were compared and the associations of these changes with clinical features were studied. RESULTS. A gain of 3q with a minimal amplified region at 3q25.3-qter was significantly higher in patients with SCC compared with patients with AC (72% vs. 27%; P < 0.001). A gain of 20q and loss of chromosome 9 were detected more frequently in patients with AC compared with patients with SCC (P < 0.05). Gains of 5p and 20q and loss of 5q were significantly correlated with an advanced stage of NSCLC (P < 0.05). Amplification of 1q was significantly associated with NSCLC recurrence (P = 0.04). CONCLUSIONS. The results of the current study suggested that different chromosomal aberrations may contribute to the types and pathologic stages of NSCLC. © 2004 American Cancer Society.
ISSN0008-543X
2011 Impact Factor: 4.771
2011 SCImago Journal Rankings: 0.578
DOIhttp://dx.doi.org/10.1002/cncr.20190
ISI Accession Number IDWOS:000220929000019
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorTai, ALS
dc.contributor.authorYan, WS
dc.contributor.authorFang, Y
dc.contributor.authorXie, D
dc.contributor.authorSham, JST
dc.contributor.authorGuan, XY
dc.date.accessioned2010-09-06T06:36:28Z
dc.date.available2010-09-06T06:36:28Z
dc.date.issued2004
dc.description.abstractBACKGROUND. Lung carcinoma is a leading cause of cancer deaths worldwide. To better understand this disease, the authors studied genetic alterations in nonsmall cell lung carcinoma (NSCLC) and the association between genetic changes and clinical features. METHODS. Genetic alterations in 30 patients with adenocarcinoma (AC) and 39 patients with squamous cell carcinoma (SCC) were analyzed by comparative genomic hybridization. The genetic changes in patients with AC and SCC were compared and the associations of these changes with clinical features were studied. RESULTS. A gain of 3q with a minimal amplified region at 3q25.3-qter was significantly higher in patients with SCC compared with patients with AC (72% vs. 27%; P < 0.001). A gain of 20q and loss of chromosome 9 were detected more frequently in patients with AC compared with patients with SCC (P < 0.05). Gains of 5p and 20q and loss of 5q were significantly correlated with an advanced stage of NSCLC (P < 0.05). Amplification of 1q was significantly associated with NSCLC recurrence (P = 0.04). CONCLUSIONS. The results of the current study suggested that different chromosomal aberrations may contribute to the types and pathologic stages of NSCLC. © 2004 American Cancer Society.
dc.description.natureLink_to_OA_fulltext
dc.identifier.citationCancer, 2004, v. 100 n. 9, p. 1918-1927 [How to Cite?]
DOI: http://dx.doi.org/10.1002/cncr.20190
dc.identifier.doihttp://dx.doi.org/10.1002/cncr.20190
dc.identifier.epage1927
dc.identifier.hkuros115339
dc.identifier.hkuros96139
dc.identifier.isiWOS:000220929000019
dc.identifier.issn0008-543X
2011 Impact Factor: 4.771
2011 SCImago Journal Rankings: 0.578
dc.identifier.issue9
dc.identifier.openurl
dc.identifier.pmid15112273
dc.identifier.scopuseid_2-s2.0-1942499002
dc.identifier.spage1918
dc.identifier.urihttp://hdl.handle.net/10722/71917
dc.identifier.volume100
dc.languageeng
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/28741
dc.publisher.placeUnited States
dc.relation.ispartofCancer
dc.relation.referencesReferences in Scopus
dc.rightsCancer. Copyright © John Wiley & Sons, Inc.
dc.subject.meshAdenocarcinoma - genetics - mortality - therapy
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshBlotting, Southern
dc.subject.meshCarcinoma, Non-Small-Cell Lung - genetics - mortality - therapy
dc.subject.meshCarcinoma, Squamous Cell - genetics - mortality - therapy
dc.subject.meshChromosome Aberrations
dc.subject.meshCohort Studies
dc.subject.meshCombined Modality Therapy
dc.subject.meshDNA, Neoplasm - analysis
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshLung Neoplasms - genetics - mortality - therapy
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshNeoplasm Recurrence, Local - epidemiology - genetics
dc.subject.meshNucleic Acid Hybridization
dc.subject.meshProbability
dc.subject.meshPrognosis
dc.subject.meshRisk Assessment
dc.subject.meshSensitivity and Specificity
dc.subject.meshSurvival Analysis
dc.titleRecurrent Chromosomal Imbalances in Nonsmall Cell Lung Carcinoma: The Association between 1q Amplification and Tumor Recurrence
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong
  2. Sun Yat-Sen University