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Article: Recurrent Chromosomal Imbalances in Nonsmall Cell Lung Carcinoma: The Association between 1q Amplification and Tumor Recurrence

TitleRecurrent Chromosomal Imbalances in Nonsmall Cell Lung Carcinoma: The Association between 1q Amplification and Tumor Recurrence
Authors
Issue Date2004
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/28741
Citation
Cancer, 2004, v. 100 n. 9, p. 1918-1927 How to Cite?
Abstract
BACKGROUND. Lung carcinoma is a leading cause of cancer deaths worldwide. To better understand this disease, the authors studied genetic alterations in nonsmall cell lung carcinoma (NSCLC) and the association between genetic changes and clinical features. METHODS. Genetic alterations in 30 patients with adenocarcinoma (AC) and 39 patients with squamous cell carcinoma (SCC) were analyzed by comparative genomic hybridization. The genetic changes in patients with AC and SCC were compared and the associations of these changes with clinical features were studied. RESULTS. A gain of 3q with a minimal amplified region at 3q25.3-qter was significantly higher in patients with SCC compared with patients with AC (72% vs. 27%; P < 0.001). A gain of 20q and loss of chromosome 9 were detected more frequently in patients with AC compared with patients with SCC (P < 0.05). Gains of 5p and 20q and loss of 5q were significantly correlated with an advanced stage of NSCLC (P < 0.05). Amplification of 1q was significantly associated with NSCLC recurrence (P = 0.04). CONCLUSIONS. The results of the current study suggested that different chromosomal aberrations may contribute to the types and pathologic stages of NSCLC. © 2004 American Cancer Society.
Persistent Identifierhttp://hdl.handle.net/10722/71917
ISSN
2013 Impact Factor: 4.901
ISI Accession Number ID
References

 

Author Affiliations
  1. The University of Hong Kong
  2. Sun Yat-Sen University
DC FieldValueLanguage
dc.contributor.authorTai, ALSen_HK
dc.contributor.authorYan, WSen_HK
dc.contributor.authorFang, Yen_HK
dc.contributor.authorXie, Den_HK
dc.contributor.authorSham, JSTen_HK
dc.contributor.authorGuan, XYen_HK
dc.date.accessioned2010-09-06T06:36:28Z-
dc.date.available2010-09-06T06:36:28Z-
dc.date.issued2004en_HK
dc.identifier.citationCancer, 2004, v. 100 n. 9, p. 1918-1927en_HK
dc.identifier.issn0008-543Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/71917-
dc.description.abstractBACKGROUND. Lung carcinoma is a leading cause of cancer deaths worldwide. To better understand this disease, the authors studied genetic alterations in nonsmall cell lung carcinoma (NSCLC) and the association between genetic changes and clinical features. METHODS. Genetic alterations in 30 patients with adenocarcinoma (AC) and 39 patients with squamous cell carcinoma (SCC) were analyzed by comparative genomic hybridization. The genetic changes in patients with AC and SCC were compared and the associations of these changes with clinical features were studied. RESULTS. A gain of 3q with a minimal amplified region at 3q25.3-qter was significantly higher in patients with SCC compared with patients with AC (72% vs. 27%; P < 0.001). A gain of 20q and loss of chromosome 9 were detected more frequently in patients with AC compared with patients with SCC (P < 0.05). Gains of 5p and 20q and loss of 5q were significantly correlated with an advanced stage of NSCLC (P < 0.05). Amplification of 1q was significantly associated with NSCLC recurrence (P = 0.04). CONCLUSIONS. The results of the current study suggested that different chromosomal aberrations may contribute to the types and pathologic stages of NSCLC. © 2004 American Cancer Society.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/28741en_HK
dc.relation.ispartofCanceren_HK
dc.rightsCancer. Copyright © John Wiley & Sons, Inc.en_HK
dc.subject.meshAdenocarcinoma - genetics - mortality - therapyen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshBlotting, Southernen_HK
dc.subject.meshCarcinoma, Non-Small-Cell Lung - genetics - mortality - therapyen_HK
dc.subject.meshCarcinoma, Squamous Cell - genetics - mortality - therapyen_HK
dc.subject.meshChromosome Aberrationsen_HK
dc.subject.meshCohort Studiesen_HK
dc.subject.meshCombined Modality Therapyen_HK
dc.subject.meshDNA, Neoplasm - analysisen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLung Neoplasms - genetics - mortality - therapyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshNeoplasm Recurrence, Local - epidemiology - geneticsen_HK
dc.subject.meshNucleic Acid Hybridizationen_HK
dc.subject.meshProbabilityen_HK
dc.subject.meshPrognosisen_HK
dc.subject.meshRisk Assessmenten_HK
dc.subject.meshSensitivity and Specificityen_HK
dc.subject.meshSurvival Analysisen_HK
dc.titleRecurrent Chromosomal Imbalances in Nonsmall Cell Lung Carcinoma: The Association between 1q Amplification and Tumor Recurrenceen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0008-543X&volume=100&issue=9&spage=1918&epage=1927&date=2004&atitle=Recurrent+chromosomal+imbalances+in+nonsmall+cell+lung+carcinoma:+the+association+between+1q+amplification+and+tumor+recurrenceen_HK
dc.identifier.emailGuan, XY:xyguan@hkucc.hku.hken_HK
dc.identifier.authorityGuan, XY=rp00454en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1002/cncr.20190en_HK
dc.identifier.pmid15112273en_HK
dc.identifier.scopuseid_2-s2.0-1942499002en_HK
dc.identifier.hkuros115339en_HK
dc.identifier.hkuros96139-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-1942499002&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume100en_HK
dc.identifier.issue9en_HK
dc.identifier.spage1918en_HK
dc.identifier.epage1927en_HK
dc.identifier.isiWOS:000220929000019-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridTai, ALS=8234187900en_HK
dc.identifier.scopusauthoridYan, WS=9234252900en_HK
dc.identifier.scopusauthoridFang, Y=7403457405en_HK
dc.identifier.scopusauthoridXie, D=35070710200en_HK
dc.identifier.scopusauthoridSham, JST=24472255400en_HK
dc.identifier.scopusauthoridGuan, XY=7201463221en_HK

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