File Download
 
Links for fulltext
(May Require Subscription)
 
Supplementary

Article: Evaluation of cervical nodal necrosis in nasopharyngeal carcinoma by computed tomography: Incidence and prognostic significance
  • Basic View
  • Metadata View
  • XML View
TitleEvaluation of cervical nodal necrosis in nasopharyngeal carcinoma by computed tomography: Incidence and prognostic significance
 
AuthorsChua, DTT1
Sham, JST1
Kwong, DLW1
Choy, DTK1
Leong, L2
Chan, FL2
 
KeywordsChemotherapy
Computed tomography
Nasopharyngeal carcinoma
Nodal necrosis
Radiotherapy
 
Issue Date1997
 
PublisherJohn Wiley & Sons, Inc.. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38137
 
CitationHead And Neck, 1997, v. 19 n. 4, p. 266-275 [How to Cite?]
 
AbstractPurpose. The purpose was to study the prognostic value of contrast- enhanced computed tomography (CT) nodal necrosis in nasopharyngeal carcinoma. Patients and methods. One hundred sixty-one patients with newly diagnosed nasopharyngeal carcinoma and nodal metastases were reviewed. Forty patients also received cisplatin-based neoadjuvant chemotherapy in addition to radiotherapy. Nodal necrosis was defined as presence of hypodense areas in more than 33% of the node. Nodal response rate to chemotherapy, overall nodal control rate, local control rate, distant failure rate, overall relapse-free survival rate, and overall and cause-specific survival rates were compared between patients with and without nodal necrosis. Multivariate analysis was also performed. Results. The incidence of nodal necrosis was 22.9%. Overall nodal response rates to chemotherapy were 88.9% (8/9) in patients with nodal necrosis and 74.2% (23/31) in those without. NO significant differences in nodal control rate, local control rate, distant failure rate, and overall and cause-specific survival rates were found. Five-year overall relapse-free survival rate was lower in patients with cervical nodal necrosis (36%) as compared with those without (53%, p = .04). Multivariate analysis, however, did not confirm cervical nodal necrosis to be an independent prognostic factor. Conclusions. Presence of nodal necrosis in nasopparyngeal carcinoma does not affect nodal response to chemotherapy and nodal control by radiotherapy with or without chemotherapy. Cervical nodal necrosis does not appear to be an independent factor in predicting treatment outcome. Further studies to correlate nodal density with oxygenation status as well as tumor cell kinetics are warranted.
 
ISSN0148-6403
 
ISI Accession Number IDWOS:A1997XG72600004
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorChua, DTT
 
dc.contributor.authorSham, JST
 
dc.contributor.authorKwong, DLW
 
dc.contributor.authorChoy, DTK
 
dc.contributor.authorLeong, L
 
dc.contributor.authorChan, FL
 
dc.date.accessioned2010-09-06T06:36:24Z
 
dc.date.available2010-09-06T06:36:24Z
 
dc.date.issued1997
 
dc.description.abstractPurpose. The purpose was to study the prognostic value of contrast- enhanced computed tomography (CT) nodal necrosis in nasopharyngeal carcinoma. Patients and methods. One hundred sixty-one patients with newly diagnosed nasopharyngeal carcinoma and nodal metastases were reviewed. Forty patients also received cisplatin-based neoadjuvant chemotherapy in addition to radiotherapy. Nodal necrosis was defined as presence of hypodense areas in more than 33% of the node. Nodal response rate to chemotherapy, overall nodal control rate, local control rate, distant failure rate, overall relapse-free survival rate, and overall and cause-specific survival rates were compared between patients with and without nodal necrosis. Multivariate analysis was also performed. Results. The incidence of nodal necrosis was 22.9%. Overall nodal response rates to chemotherapy were 88.9% (8/9) in patients with nodal necrosis and 74.2% (23/31) in those without. NO significant differences in nodal control rate, local control rate, distant failure rate, and overall and cause-specific survival rates were found. Five-year overall relapse-free survival rate was lower in patients with cervical nodal necrosis (36%) as compared with those without (53%, p = .04). Multivariate analysis, however, did not confirm cervical nodal necrosis to be an independent prognostic factor. Conclusions. Presence of nodal necrosis in nasopparyngeal carcinoma does not affect nodal response to chemotherapy and nodal control by radiotherapy with or without chemotherapy. Cervical nodal necrosis does not appear to be an independent factor in predicting treatment outcome. Further studies to correlate nodal density with oxygenation status as well as tumor cell kinetics are warranted.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationHead And Neck, 1997, v. 19 n. 4, p. 266-275 [How to Cite?]
 
dc.identifier.epage275
 
dc.identifier.hkuros34745
 
dc.identifier.isiWOS:A1997XG72600004
 
dc.identifier.issn0148-6403
 
dc.identifier.issue4
 
dc.identifier.openurl
 
dc.identifier.pmid9213104
 
dc.identifier.scopuseid_2-s2.0-0030955654
 
dc.identifier.spage266
 
dc.identifier.urihttp://hdl.handle.net/10722/71911
 
dc.identifier.volume19
 
dc.languageeng
 
dc.publisherJohn Wiley & Sons, Inc.. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38137
 
dc.publisher.placeUnited States
 
dc.relation.ispartofHead and Neck
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAdult
 
dc.subject.meshAnalysis of Variance
 
dc.subject.meshChemotherapy, Adjuvant
 
dc.subject.meshCombined Modality Therapy
 
dc.subject.meshFemale
 
dc.subject.meshHumans
 
dc.subject.meshLymphatic Metastasis - pathology
 
dc.subject.meshMale
 
dc.subject.meshMiddle Aged
 
dc.subject.meshNasopharyngeal Neoplasms - drug therapy - pathology - radiography - radiotherapy
 
dc.subject.meshNecrosis
 
dc.subject.meshNeoplasm Staging
 
dc.subject.meshPrognosis
 
dc.subject.meshSurvival Rate
 
dc.subject.meshTomography, X-Ray Computed
 
dc.subjectChemotherapy
 
dc.subjectComputed tomography
 
dc.subjectNasopharyngeal carcinoma
 
dc.subjectNodal necrosis
 
dc.subjectRadiotherapy
 
dc.titleEvaluation of cervical nodal necrosis in nasopharyngeal carcinoma by computed tomography: Incidence and prognostic significance
 
dc.typeArticle
 
<?xml encoding="utf-8" version="1.0"?>
<item><contributor.author>Chua, DTT</contributor.author>
<contributor.author>Sham, JST</contributor.author>
<contributor.author>Kwong, DLW</contributor.author>
<contributor.author>Choy, DTK</contributor.author>
<contributor.author>Leong, L</contributor.author>
<contributor.author>Chan, FL</contributor.author>
<date.accessioned>2010-09-06T06:36:24Z</date.accessioned>
<date.available>2010-09-06T06:36:24Z</date.available>
<date.issued>1997</date.issued>
<identifier.citation>Head And Neck, 1997, v. 19 n. 4, p. 266-275</identifier.citation>
<identifier.issn>0148-6403</identifier.issn>
<identifier.uri>http://hdl.handle.net/10722/71911</identifier.uri>
<description.abstract>Purpose. The purpose was to study the prognostic value of contrast- enhanced computed tomography (CT) nodal necrosis in nasopharyngeal carcinoma. Patients and methods. One hundred sixty-one patients with newly diagnosed nasopharyngeal carcinoma and nodal metastases were reviewed. Forty patients also received cisplatin-based neoadjuvant chemotherapy in addition to radiotherapy. Nodal necrosis was defined as presence of hypodense areas in more than 33% of the node. Nodal response rate to chemotherapy, overall nodal control rate, local control rate, distant failure rate, overall relapse-free survival rate, and overall and cause-specific survival rates were compared between patients with and without nodal necrosis. Multivariate analysis was also performed. Results. The incidence of nodal necrosis was 22.9%. Overall nodal response rates to chemotherapy were 88.9% (8/9) in patients with nodal necrosis and 74.2% (23/31) in those without. NO significant differences in nodal control rate, local control rate, distant failure rate, and overall and cause-specific survival rates were found. Five-year overall relapse-free survival rate was lower in patients with cervical nodal necrosis (36%) as compared with those without (53%, p = .04). Multivariate analysis, however, did not confirm cervical nodal necrosis to be an independent prognostic factor. Conclusions. Presence of nodal necrosis in nasopparyngeal carcinoma does not affect nodal response to chemotherapy and nodal control by radiotherapy with or without chemotherapy. Cervical nodal necrosis does not appear to be an independent factor in predicting treatment outcome. Further studies to correlate nodal density with oxygenation status as well as tumor cell kinetics are warranted.</description.abstract>
<language>eng</language>
<publisher>John Wiley &amp; Sons, Inc.. The Journal&apos;s web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38137</publisher>
<relation.ispartof>Head and Neck</relation.ispartof>
<subject>Chemotherapy</subject>
<subject>Computed tomography</subject>
<subject>Nasopharyngeal carcinoma</subject>
<subject>Nodal necrosis</subject>
<subject>Radiotherapy</subject>
<subject.mesh>Adult</subject.mesh>
<subject.mesh>Analysis of Variance</subject.mesh>
<subject.mesh>Chemotherapy, Adjuvant</subject.mesh>
<subject.mesh>Combined Modality Therapy</subject.mesh>
<subject.mesh>Female</subject.mesh>
<subject.mesh>Humans</subject.mesh>
<subject.mesh>Lymphatic Metastasis - pathology</subject.mesh>
<subject.mesh>Male</subject.mesh>
<subject.mesh>Middle Aged</subject.mesh>
<subject.mesh>Nasopharyngeal Neoplasms - drug therapy - pathology - radiography - radiotherapy</subject.mesh>
<subject.mesh>Necrosis</subject.mesh>
<subject.mesh>Neoplasm Staging</subject.mesh>
<subject.mesh>Prognosis</subject.mesh>
<subject.mesh>Survival Rate</subject.mesh>
<subject.mesh>Tomography, X-Ray Computed</subject.mesh>
<title>Evaluation of cervical nodal necrosis in nasopharyngeal carcinoma by computed tomography: Incidence and prognostic significance</title>
<type>Article</type>
<identifier.openurl>http://library.hku.hk:4550/resserv?sid=HKU:IR&amp;issn=0017-8748&amp;volume=19&amp;spage=266&amp;epage=275&amp;date=1997&amp;atitle=Evaluation+of+cervical+nodal+necrosis+in+nasopharyngeal+carcinoma+by+computed+tomography:+Incidence+and+prognostic+significance</identifier.openurl>
<description.nature>Link_to_subscribed_fulltext</description.nature>
<identifier.pmid>9213104</identifier.pmid>
<identifier.scopus>eid_2-s2.0-0030955654</identifier.scopus>
<identifier.hkuros>34745</identifier.hkuros>
<relation.references>http://www.scopus.com/mlt/select.url?eid=2-s2.0-0030955654&amp;selection=ref&amp;src=s&amp;origin=recordpage</relation.references>
<identifier.volume>19</identifier.volume>
<identifier.issue>4</identifier.issue>
<identifier.spage>266</identifier.spage>
<identifier.epage>275</identifier.epage>
<identifier.isi>WOS:A1997XG72600004</identifier.isi>
<publisher.place>United States</publisher.place>
</item>
Author Affiliations
  1. The University of Hong Kong
  2. Queen Mary Hospital Hong Kong