File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Evaluation of cervical nodal necrosis in nasopharyngeal carcinoma by computed tomography: Incidence and prognostic significance

TitleEvaluation of cervical nodal necrosis in nasopharyngeal carcinoma by computed tomography: Incidence and prognostic significance
Authors
KeywordsChemotherapy
Computed tomography
Nasopharyngeal carcinoma
Nodal necrosis
Radiotherapy
Issue Date1997
PublisherJohn Wiley & Sons, Inc.. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38137
Citation
Head And Neck, 1997, v. 19 n. 4, p. 266-275 How to Cite?
Abstract
Purpose. The purpose was to study the prognostic value of contrast- enhanced computed tomography (CT) nodal necrosis in nasopharyngeal carcinoma. Patients and methods. One hundred sixty-one patients with newly diagnosed nasopharyngeal carcinoma and nodal metastases were reviewed. Forty patients also received cisplatin-based neoadjuvant chemotherapy in addition to radiotherapy. Nodal necrosis was defined as presence of hypodense areas in more than 33% of the node. Nodal response rate to chemotherapy, overall nodal control rate, local control rate, distant failure rate, overall relapse-free survival rate, and overall and cause-specific survival rates were compared between patients with and without nodal necrosis. Multivariate analysis was also performed. Results. The incidence of nodal necrosis was 22.9%. Overall nodal response rates to chemotherapy were 88.9% (8/9) in patients with nodal necrosis and 74.2% (23/31) in those without. NO significant differences in nodal control rate, local control rate, distant failure rate, and overall and cause-specific survival rates were found. Five-year overall relapse-free survival rate was lower in patients with cervical nodal necrosis (36%) as compared with those without (53%, p = .04). Multivariate analysis, however, did not confirm cervical nodal necrosis to be an independent prognostic factor. Conclusions. Presence of nodal necrosis in nasopparyngeal carcinoma does not affect nodal response to chemotherapy and nodal control by radiotherapy with or without chemotherapy. Cervical nodal necrosis does not appear to be an independent factor in predicting treatment outcome. Further studies to correlate nodal density with oxygenation status as well as tumor cell kinetics are warranted.
Persistent Identifierhttp://hdl.handle.net/10722/71911
ISSN
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChua, DTTen_HK
dc.contributor.authorSham, JSTen_HK
dc.contributor.authorKwong, DLWen_HK
dc.contributor.authorChoy, DTKen_HK
dc.contributor.authorLeong, Len_HK
dc.contributor.authorChan, FLen_HK
dc.date.accessioned2010-09-06T06:36:24Z-
dc.date.available2010-09-06T06:36:24Z-
dc.date.issued1997en_HK
dc.identifier.citationHead And Neck, 1997, v. 19 n. 4, p. 266-275en_HK
dc.identifier.issn0148-6403en_HK
dc.identifier.urihttp://hdl.handle.net/10722/71911-
dc.description.abstractPurpose. The purpose was to study the prognostic value of contrast- enhanced computed tomography (CT) nodal necrosis in nasopharyngeal carcinoma. Patients and methods. One hundred sixty-one patients with newly diagnosed nasopharyngeal carcinoma and nodal metastases were reviewed. Forty patients also received cisplatin-based neoadjuvant chemotherapy in addition to radiotherapy. Nodal necrosis was defined as presence of hypodense areas in more than 33% of the node. Nodal response rate to chemotherapy, overall nodal control rate, local control rate, distant failure rate, overall relapse-free survival rate, and overall and cause-specific survival rates were compared between patients with and without nodal necrosis. Multivariate analysis was also performed. Results. The incidence of nodal necrosis was 22.9%. Overall nodal response rates to chemotherapy were 88.9% (8/9) in patients with nodal necrosis and 74.2% (23/31) in those without. NO significant differences in nodal control rate, local control rate, distant failure rate, and overall and cause-specific survival rates were found. Five-year overall relapse-free survival rate was lower in patients with cervical nodal necrosis (36%) as compared with those without (53%, p = .04). Multivariate analysis, however, did not confirm cervical nodal necrosis to be an independent prognostic factor. Conclusions. Presence of nodal necrosis in nasopparyngeal carcinoma does not affect nodal response to chemotherapy and nodal control by radiotherapy with or without chemotherapy. Cervical nodal necrosis does not appear to be an independent factor in predicting treatment outcome. Further studies to correlate nodal density with oxygenation status as well as tumor cell kinetics are warranted.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc.. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38137en_HK
dc.relation.ispartofHead and Necken_HK
dc.subjectChemotherapyen_HK
dc.subjectComputed tomographyen_HK
dc.subjectNasopharyngeal carcinomaen_HK
dc.subjectNodal necrosisen_HK
dc.subjectRadiotherapyen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAnalysis of Varianceen_HK
dc.subject.meshChemotherapy, Adjuvanten_HK
dc.subject.meshCombined Modality Therapyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLymphatic Metastasis - pathologyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshNasopharyngeal Neoplasms - drug therapy - pathology - radiography - radiotherapyen_HK
dc.subject.meshNecrosisen_HK
dc.subject.meshNeoplasm Stagingen_HK
dc.subject.meshPrognosisen_HK
dc.subject.meshSurvival Rateen_HK
dc.subject.meshTomography, X-Ray Computeden_HK
dc.titleEvaluation of cervical nodal necrosis in nasopharyngeal carcinoma by computed tomography: Incidence and prognostic significanceen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0017-8748&volume=19&spage=266&epage=275&date=1997&atitle=Evaluation+of+cervical+nodal+necrosis+in+nasopharyngeal+carcinoma+by+computed+tomography:+Incidence+and+prognostic+significanceen_HK
dc.identifier.emailChua, DTT: dttchua@hkucc.hku.hken_HK
dc.identifier.emailKwong, DLW: dlwkwong@hku.hken_HK
dc.identifier.authorityChua, DTT=rp00415en_HK
dc.identifier.authorityKwong, DLW=rp00414en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid9213104en_HK
dc.identifier.scopuseid_2-s2.0-0030955654en_HK
dc.identifier.hkuros34745en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030955654&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume19en_HK
dc.identifier.issue4en_HK
dc.identifier.spage266en_HK
dc.identifier.epage275en_HK
dc.identifier.isiWOS:A1997XG72600004-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridChua, DTT=7006773480en_HK
dc.identifier.scopusauthoridSham, JST=24472255400en_HK
dc.identifier.scopusauthoridKwong, DLW=15744231600en_HK
dc.identifier.scopusauthoridChoy, DTK=7102939127en_HK
dc.identifier.scopusauthoridLeong, L=7004323766en_HK
dc.identifier.scopusauthoridChan, FL=7202586444en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats