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Article: Multidisciplinary management of osteosarcoma: Experience in Hong Kong

TitleMultidisciplinary management of osteosarcoma: Experience in Hong Kong
Authors
KeywordsMultidisciplianry care
Osteosarcoma
Pediatric
Issue Date1998
PublisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/08880018.asp
Citation
Pediatric Hematology And Oncology, 1998, v. 15 n. 3, p. 229-236 How to Cite?
AbstractAll pediatric osteosarcomas treated in our hospital between 1985 and 1995 were reviewed. There were 26 patients, 15 males and 11 females, aged 20 or less at diagnosis. All had limb primaries. Nineteen patients had localized disease and seven presented with metastases. Intensive multiagent chemotherapy was given both pre- and postoperatively. Most patients had limb salvage surgery; all others had amputation. With a median follow-up of 74 months, the 5-years disease-free survival among patients with localized disease was 65.2%. Being female and having a high 6-hour postinfusion methotrexate level with a median level greater than 700 μmol/L were good prognostic factors. Three of the seven patients with metastatic disease were alive at 21, 26, and 140 months after diagnosis. All of them had lung secondaries. Survival rates achieved in our center were comparable to those reported in literature. However, our amputation rate was high and further development in expertise for limb salvage treatment is a goal.
Persistent Identifierhttp://hdl.handle.net/10722/71910
ISSN
2015 Impact Factor: 1.09
2015 SCImago Journal Rankings: 0.473
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorKwong, DLWen_HK
dc.contributor.authorHa, SYen_HK
dc.contributor.authorChau, KYen_HK
dc.contributor.authorChoi, PHKen_HK
dc.contributor.authorChan, GCFen_HK
dc.contributor.authorKwong, PWKen_HK
dc.contributor.authorLau, YLen_HK
dc.date.accessioned2010-09-06T06:36:23Z-
dc.date.available2010-09-06T06:36:23Z-
dc.date.issued1998en_HK
dc.identifier.citationPediatric Hematology And Oncology, 1998, v. 15 n. 3, p. 229-236en_HK
dc.identifier.issn0888-0018en_HK
dc.identifier.urihttp://hdl.handle.net/10722/71910-
dc.description.abstractAll pediatric osteosarcomas treated in our hospital between 1985 and 1995 were reviewed. There were 26 patients, 15 males and 11 females, aged 20 or less at diagnosis. All had limb primaries. Nineteen patients had localized disease and seven presented with metastases. Intensive multiagent chemotherapy was given both pre- and postoperatively. Most patients had limb salvage surgery; all others had amputation. With a median follow-up of 74 months, the 5-years disease-free survival among patients with localized disease was 65.2%. Being female and having a high 6-hour postinfusion methotrexate level with a median level greater than 700 μmol/L were good prognostic factors. Three of the seven patients with metastatic disease were alive at 21, 26, and 140 months after diagnosis. All of them had lung secondaries. Survival rates achieved in our center were comparable to those reported in literature. However, our amputation rate was high and further development in expertise for limb salvage treatment is a goal.en_HK
dc.languageengen_HK
dc.publisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/08880018.aspen_HK
dc.relation.ispartofPediatric Hematology and Oncologyen_HK
dc.subjectMultidisciplianry careen_HK
dc.subjectOsteosarcomaen_HK
dc.subjectPediatricen_HK
dc.subject.meshAdolescenten_HK
dc.subject.meshAdulten_HK
dc.subject.meshAntineoplastic Combined Chemotherapy Protocols - administration & dosageen_HK
dc.subject.meshBone Neoplasms - drug therapy - epidemiology - pathology - surgeryen_HK
dc.subject.meshChilden_HK
dc.subject.meshChild, Preschoolen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHong Kong - epidemiologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMaleen_HK
dc.subject.meshNeoplasm Metastasisen_HK
dc.subject.meshOsteosarcoma - drug therapy - epidemiology - pathology - surgeryen_HK
dc.subject.meshRecurrenceen_HK
dc.subject.meshSurvival Analysisen_HK
dc.titleMultidisciplinary management of osteosarcoma: Experience in Hong Kongen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0931-041X&volume=15&spage=229&epage=236&date=1998&atitle=Multidisciplinary+Management+of+Osteosarcoma:+Experience+in+Hong+Kongen_HK
dc.identifier.emailKwong, DLW:dlwkwong@hku.hken_HK
dc.identifier.emailChan, GCF:gcfchan@hkucc.hku.hken_HK
dc.identifier.emailLau, YL:lauylung@hkucc.hku.hken_HK
dc.identifier.authorityKwong, DLW=rp00414en_HK
dc.identifier.authorityChan, GCF=rp00431en_HK
dc.identifier.authorityLau, YL=rp00361en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid9615320-
dc.identifier.scopuseid_2-s2.0-0031842046en_HK
dc.identifier.hkuros31566en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0031842046&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume15en_HK
dc.identifier.issue3en_HK
dc.identifier.spage229en_HK
dc.identifier.epage236en_HK
dc.identifier.isiWOS:000073796100006-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridKwong, DLW=15744231600en_HK
dc.identifier.scopusauthoridHa, SY=7202501115en_HK
dc.identifier.scopusauthoridChau, KY=20533659300en_HK
dc.identifier.scopusauthoridChoi, PHK=7102909162en_HK
dc.identifier.scopusauthoridChan, GCF=16160154400en_HK
dc.identifier.scopusauthoridKwong, PWK=7006992418en_HK
dc.identifier.scopusauthoridLau, YL=7201403380en_HK

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