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Article: Cytogenetic and molecular genetic alterations in hepatocellular carcinoma

TitleCytogenetic and molecular genetic alterations in hepatocellular carcinoma
Authors
Issue Date2005
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/aps/index.html
Citation
Acta Pharmacologica Sinica, 2005, v. 26 n. 6, p. 659-665 How to Cite?
AbstractSpecific chromosome aberrations are frequently detected during the development of hepatocellular carcinoma. Molecular cytogenetic approaches such as comparative genomic hybridization and loss of heterozygosity analyses have provided fruitful information on changes in HCC cases at the genomic level. Mapping of chromosome gains and losses have frequently resulted in the identification of oncogenes and tumor suppressors, respectively. In this review, we summarize some frequently detected chromosomal aberrations reported for hepatocellular carcinoma cases using comparative genomic hybridization and loss of heterozygosity studies. Focus will be on gains of 1q, 8q, and 20q, and losses of 4q, 8p, 13q, 16q, and 17p. We then examine the candidate oncogenes and tumor suppressors located within these regions, and explore their possible functions in hepatocarcinogenesis. Finally, the impact of microarray-based screening platforms will be discussed. © 2005 CPS and SIMM.
Persistent Identifierhttp://hdl.handle.net/10722/71906
ISSN
2015 Impact Factor: 3.166
2015 SCImago Journal Rankings: 1.161
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLau, SHen_HK
dc.contributor.authorGuan, XYen_HK
dc.date.accessioned2010-09-06T06:36:21Z-
dc.date.available2010-09-06T06:36:21Z-
dc.date.issued2005en_HK
dc.identifier.citationActa Pharmacologica Sinica, 2005, v. 26 n. 6, p. 659-665en_HK
dc.identifier.issn1671-4083en_HK
dc.identifier.urihttp://hdl.handle.net/10722/71906-
dc.description.abstractSpecific chromosome aberrations are frequently detected during the development of hepatocellular carcinoma. Molecular cytogenetic approaches such as comparative genomic hybridization and loss of heterozygosity analyses have provided fruitful information on changes in HCC cases at the genomic level. Mapping of chromosome gains and losses have frequently resulted in the identification of oncogenes and tumor suppressors, respectively. In this review, we summarize some frequently detected chromosomal aberrations reported for hepatocellular carcinoma cases using comparative genomic hybridization and loss of heterozygosity studies. Focus will be on gains of 1q, 8q, and 20q, and losses of 4q, 8p, 13q, 16q, and 17p. We then examine the candidate oncogenes and tumor suppressors located within these regions, and explore their possible functions in hepatocarcinogenesis. Finally, the impact of microarray-based screening platforms will be discussed. © 2005 CPS and SIMM.en_HK
dc.languageengen_HK
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/aps/index.htmlen_HK
dc.relation.ispartofActa Pharmacologica Sinicaen_HK
dc.subject.meshCarcinoma, Hepatocellular - geneticsen_HK
dc.subject.meshChromosome Aberrationsen_HK
dc.subject.meshChromosome Deletionen_HK
dc.subject.meshChromosome Mappingen_HK
dc.subject.meshGene Amplificationen_HK
dc.subject.meshGenes, Tumor Suppressoren_HK
dc.subject.meshHumansen_HK
dc.subject.meshLiver Neoplasms - geneticsen_HK
dc.subject.meshNucleic Acid Hybridizationen_HK
dc.subject.meshOligonucleotide Array Sequence Analysisen_HK
dc.subject.meshOncogenesen_HK
dc.titleCytogenetic and molecular genetic alterations in hepatocellular carcinomaen_HK
dc.typeArticleen_HK
dc.identifier.emailGuan, XY:xyguan@hkucc.hku.hken_HK
dc.identifier.authorityGuan, XY=rp00454en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1111/j.1745-7254.2005.00126.xen_HK
dc.identifier.pmid15916730en_HK
dc.identifier.scopuseid_2-s2.0-20444393130en_HK
dc.identifier.hkuros100390en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-20444393130&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume26en_HK
dc.identifier.issue6en_HK
dc.identifier.spage659en_HK
dc.identifier.epage665en_HK
dc.identifier.isiWOS:000229917700003-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLau, SH=7401596190en_HK
dc.identifier.scopusauthoridGuan, XY=7201463221en_HK

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