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Article: Peripheral γδ T-cell deficit in nasopharyngeal carcinoma

TitlePeripheral γδ T-cell deficit in nasopharyngeal carcinoma
Authors
Keywordsγδ T cells
Immune deficit
NPC
Tumor immunity
Issue Date2002
PublisherJohn Wiley & Sons, Inc.. The Journal's web site is located at http://www3.interscience.wiley.com/journal/29331/home
Citation
International Journal Of Cancer, 2002, v. 99 n. 2, p. 213-217 How to Cite?
AbstractPrevious studies identified CD56 + and CD56 - subsets of peripheral γδ T cells from healthy donors. Both subsets responded to stimulation by a myeloma cell line, XG-7 and undergo vigorous ex vivo expansion in the presence of exogenous IL-2. They are cytotoxic for different tumor targets including nasopharyngeal carcinoma, but they differ from one another in that the CD56 - subset has an additional growth requirement for IL-7 and exhibited greater cytotoxicity against nasopharyngeal carcinoma (NPC) targets. These immune cells were further shown to retard tumor growth in a nude mice NPC model. To assess if these immune cells might contribute to host defense against NPC, we compared γδ T-cell status of NPC patients with healthy donors and survivors who had been in clinical remission of the cancer. It was found that peripheral γδ T cells of patients were impaired in their response to the stimulatory effects of XG-7 and exhibited weak or essentially no cytotoxicity for the NPC targets. The deficits were present in early and advanced stages of the cancer but were restored among survivors after successful treatment of the cancer. These findings support a role for peripheral γδ T cells in host defense against NPC. It was noted that these immune cells comprise less than 5% of peripheral blood monocytic cells and hence it was not surprising that this component of host defense was breached early in the development of the cancer. © 2002 Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/71896
ISSN
2015 Impact Factor: 5.531
2015 SCImago Journal Rankings: 2.657
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZheng, BJen_HK
dc.contributor.authorNg, SPen_HK
dc.contributor.authorChua, DTTen_HK
dc.contributor.authorSham, JSTen_HK
dc.contributor.authorKwong, DLWen_HK
dc.contributor.authorLam, CKen_HK
dc.contributor.authorNg, MHen_HK
dc.date.accessioned2010-09-06T06:36:14Z-
dc.date.available2010-09-06T06:36:14Z-
dc.date.issued2002en_HK
dc.identifier.citationInternational Journal Of Cancer, 2002, v. 99 n. 2, p. 213-217en_HK
dc.identifier.issn0020-7136en_HK
dc.identifier.urihttp://hdl.handle.net/10722/71896-
dc.description.abstractPrevious studies identified CD56 + and CD56 - subsets of peripheral γδ T cells from healthy donors. Both subsets responded to stimulation by a myeloma cell line, XG-7 and undergo vigorous ex vivo expansion in the presence of exogenous IL-2. They are cytotoxic for different tumor targets including nasopharyngeal carcinoma, but they differ from one another in that the CD56 - subset has an additional growth requirement for IL-7 and exhibited greater cytotoxicity against nasopharyngeal carcinoma (NPC) targets. These immune cells were further shown to retard tumor growth in a nude mice NPC model. To assess if these immune cells might contribute to host defense against NPC, we compared γδ T-cell status of NPC patients with healthy donors and survivors who had been in clinical remission of the cancer. It was found that peripheral γδ T cells of patients were impaired in their response to the stimulatory effects of XG-7 and exhibited weak or essentially no cytotoxicity for the NPC targets. The deficits were present in early and advanced stages of the cancer but were restored among survivors after successful treatment of the cancer. These findings support a role for peripheral γδ T cells in host defense against NPC. It was noted that these immune cells comprise less than 5% of peripheral blood monocytic cells and hence it was not surprising that this component of host defense was breached early in the development of the cancer. © 2002 Wiley-Liss, Inc.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc.. The Journal's web site is located at http://www3.interscience.wiley.com/journal/29331/homeen_HK
dc.relation.ispartofInternational Journal of Canceren_HK
dc.rightsInternational Journal of Cancer. Copyright © John Wiley & Sons, Inc..en_HK
dc.subjectγδ T cellsen_HK
dc.subjectImmune deficiten_HK
dc.subjectNPCen_HK
dc.subjectTumor immunityen_HK
dc.subject.meshCoculture Techniques-
dc.subject.meshCytotoxicity, Immunologic-
dc.subject.meshNasopharyngeal Neoplasms - immunology - pathology-
dc.subject.meshReceptors, Antigen, T-Cell, gamma-delta - analysis-
dc.subject.meshT-Lymphocytes - immunology-
dc.titlePeripheral γδ T-cell deficit in nasopharyngeal carcinomaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0020-7136&volume=99&issue=2&spage=213&epage=217&date=2002&atitle=Peripheral+γδ+T-cell+deficit+in+nasopharyngeal+carcinomaen_HK
dc.identifier.emailZheng, BJ: bzheng@hkucc.hku.hken_HK
dc.identifier.emailChua, DTT: dttchua@hkucc.hku.hken_HK
dc.identifier.emailKwong, DLW: dlwkwong@hku.hken_HK
dc.identifier.authorityZheng, BJ=rp00353en_HK
dc.identifier.authorityChua, DTT=rp00415en_HK
dc.identifier.authorityKwong, DLW=rp00414en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1002/ijc.10326en_HK
dc.identifier.pmid11979436-
dc.identifier.scopuseid_2-s2.0-0037052697en_HK
dc.identifier.hkuros106052en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037052697&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume99en_HK
dc.identifier.issue2en_HK
dc.identifier.spage213en_HK
dc.identifier.epage217en_HK
dc.identifier.isiWOS:000175301000009-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridZheng, BJ=7201780588en_HK
dc.identifier.scopusauthoridNg, SP=8862966400en_HK
dc.identifier.scopusauthoridChua, DTT=7006773480en_HK
dc.identifier.scopusauthoridSham, JST=7101655565en_HK
dc.identifier.scopusauthoridKwong, DLW=15744231600en_HK
dc.identifier.scopusauthoridLam, CK=7402990915en_HK
dc.identifier.scopusauthoridNg, MH=7202076421en_HK

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