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Article: Auto-optimisation for three-dimensional conformal radiotherapy of nasopharyngeal carcinoma

TitleAuto-optimisation for three-dimensional conformal radiotherapy of nasopharyngeal carcinoma
Authors
KeywordsDose evaluation
Inverse planning
Parotid sparing
Radiotherapy planning
Issue Date2003
PublisherWB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/radi
Citation
Radiography, 2003, v. 9 n. 3, p. 201-210 How to Cite?
AbstractPurpose: The purpose of this study was to evaluate the application of auto-optimisation in the treatment planning of three-dimensional conformal radiotherapy (3DCRT) of nasopharyngeal carcinoma (NPC). Methods: Twenty-nine NPC patients were planned by both forward planning and auto-optimisation methods. The forward plans, which consisted of three coplanar facial fields, were produced according to the routine planning criteria. The auto-optimised plans, which consisted of 5-15 (median 9) fields, were generated by the planning system after prescribing the dose requirements and the importance weightings of the planning target volume and organs at risk. Plans produced by the two planning methods were compared by the dose volume histogram, tumour control probability (TCP), conformity index and normal tissue complication probability (NTCP). Results: The auto-optimised plans reduced the average planner's time by over 35 min. It demonstrated better TCP and conformity index than the forward plans (P = 0.03 and 0.04, respectively). Besides, the parotid gland and temporo-mandibular (TM) joint were better spared with the mean dose reduction of 31.8 and 17.7%, respectively. The slight trade off was the mild dose increase in spinal cord and brain stem with their maximum doses remaining within the tolerance limits. Conclusions: The findings demonstrated the potentials of auto-optimisation for improving target dose and parotid sparing in the 3DCRT of NPC with saving of the planner's time. © 2003 The College of Radiographers. Published by Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/71893
ISSN
2015 SCImago Journal Rankings: 0.219
References

 

DC FieldValueLanguage
dc.contributor.authorWu, VWCen_HK
dc.contributor.authorKwong, DWLen_HK
dc.contributor.authorSham, JSTen_HK
dc.contributor.authorMui, AWLen_HK
dc.date.accessioned2010-09-06T06:36:12Z-
dc.date.available2010-09-06T06:36:12Z-
dc.date.issued2003en_HK
dc.identifier.citationRadiography, 2003, v. 9 n. 3, p. 201-210en_HK
dc.identifier.issn1078-8174en_HK
dc.identifier.urihttp://hdl.handle.net/10722/71893-
dc.description.abstractPurpose: The purpose of this study was to evaluate the application of auto-optimisation in the treatment planning of three-dimensional conformal radiotherapy (3DCRT) of nasopharyngeal carcinoma (NPC). Methods: Twenty-nine NPC patients were planned by both forward planning and auto-optimisation methods. The forward plans, which consisted of three coplanar facial fields, were produced according to the routine planning criteria. The auto-optimised plans, which consisted of 5-15 (median 9) fields, were generated by the planning system after prescribing the dose requirements and the importance weightings of the planning target volume and organs at risk. Plans produced by the two planning methods were compared by the dose volume histogram, tumour control probability (TCP), conformity index and normal tissue complication probability (NTCP). Results: The auto-optimised plans reduced the average planner's time by over 35 min. It demonstrated better TCP and conformity index than the forward plans (P = 0.03 and 0.04, respectively). Besides, the parotid gland and temporo-mandibular (TM) joint were better spared with the mean dose reduction of 31.8 and 17.7%, respectively. The slight trade off was the mild dose increase in spinal cord and brain stem with their maximum doses remaining within the tolerance limits. Conclusions: The findings demonstrated the potentials of auto-optimisation for improving target dose and parotid sparing in the 3DCRT of NPC with saving of the planner's time. © 2003 The College of Radiographers. Published by Elsevier Ltd. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherWB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/radien_HK
dc.relation.ispartofRadiographyen_HK
dc.subjectDose evaluationen_HK
dc.subjectInverse planningen_HK
dc.subjectParotid sparingen_HK
dc.subjectRadiotherapy planningen_HK
dc.titleAuto-optimisation for three-dimensional conformal radiotherapy of nasopharyngeal carcinomaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1078-8174&volume=9&spage=201&epage=210&date=2003&atitle=Auto-optimisation+for+three-dimensional+conformal+radiotherapy+of+nasopharyngeal+carcinomaen_HK
dc.identifier.emailKwong, DWL:dlwkwong@hku.hken_HK
dc.identifier.authorityKwong, DWL=rp00414en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S1078-8174(03)00057-9en_HK
dc.identifier.scopuseid_2-s2.0-0344445581en_HK
dc.identifier.hkuros88691en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0344445581&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume9en_HK
dc.identifier.issue3en_HK
dc.identifier.spage201en_HK
dc.identifier.epage210en_HK
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridWu, VWC=7006045803en_HK
dc.identifier.scopusauthoridKwong, DWL=15744231600en_HK
dc.identifier.scopusauthoridSham, JST=24472255400en_HK
dc.identifier.scopusauthoridMui, AWL=7004369210en_HK

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