File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Association of Vimentin overexpression and hepatocellular carcinoma metastasis

TitleAssociation of Vimentin overexpression and hepatocellular carcinoma metastasis
Authors
Issue Date2004
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/onc
Citation
Oncogene, 2004, v. 23 n. 1, p. 298-302 How to Cite?
AbstractThe poor prognosis of hepatocellular carcinoma (HCC) has been associated with recurrence and metastasis. Recently, we established a pair of HCC cell lines from a primary (H2-P) and its matched metastatic (H2-M) HCC tumors. A high density of cDNA microarray with 9184 human cDNA was used to identify the differentially expressed genes between H2-P and H2-M. Comparing with H2-P, eight upregulated and six downregulated genes were detected in H2-M. One interesting finding is the overexpression of Vimentin (VIM), a well-defined intermediate filament, which has been linked to a more aggressive status in various tumors. The correlation of overexpression of VIM and HCC metastasis was studied by immunohistochemistry using a tissue microarray with 200 primary HCCs and 60 pairs of primary and matched metastatic HCC samples. Tissue microarray demonstrated that the overexpression of VIM was significantly associated with HCC metastasis (P<0.01). This finding strongly suggests that the overexpression of VIM may play an important role in the metastasis of HCC.
Persistent Identifierhttp://hdl.handle.net/10722/71888
ISSN
2015 Impact Factor: 7.932
2015 SCImago Journal Rankings: 4.047
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHu, Len_HK
dc.contributor.authorLau, SHen_HK
dc.contributor.authorTzang, CHen_HK
dc.contributor.authorWen, JMen_HK
dc.contributor.authorWang, Wen_HK
dc.contributor.authorXie, Den_HK
dc.contributor.authorHuang, Men_HK
dc.contributor.authorWang, Yen_HK
dc.contributor.authorWu, MCen_HK
dc.contributor.authorHuang, JFen_HK
dc.contributor.authorZeng, WFen_HK
dc.contributor.authorSham, JSTen_HK
dc.contributor.authorYang, Men_HK
dc.contributor.authorGuan, XYen_HK
dc.date.accessioned2010-09-06T06:36:09Z-
dc.date.available2010-09-06T06:36:09Z-
dc.date.issued2004en_HK
dc.identifier.citationOncogene, 2004, v. 23 n. 1, p. 298-302en_HK
dc.identifier.issn0950-9232en_HK
dc.identifier.urihttp://hdl.handle.net/10722/71888-
dc.description.abstractThe poor prognosis of hepatocellular carcinoma (HCC) has been associated with recurrence and metastasis. Recently, we established a pair of HCC cell lines from a primary (H2-P) and its matched metastatic (H2-M) HCC tumors. A high density of cDNA microarray with 9184 human cDNA was used to identify the differentially expressed genes between H2-P and H2-M. Comparing with H2-P, eight upregulated and six downregulated genes were detected in H2-M. One interesting finding is the overexpression of Vimentin (VIM), a well-defined intermediate filament, which has been linked to a more aggressive status in various tumors. The correlation of overexpression of VIM and HCC metastasis was studied by immunohistochemistry using a tissue microarray with 200 primary HCCs and 60 pairs of primary and matched metastatic HCC samples. Tissue microarray demonstrated that the overexpression of VIM was significantly associated with HCC metastasis (P<0.01). This finding strongly suggests that the overexpression of VIM may play an important role in the metastasis of HCC.en_HK
dc.languageengen_HK
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/oncen_HK
dc.relation.ispartofOncogeneen_HK
dc.subject.meshAdulten_HK
dc.subject.meshCarcinoma, Hepatocellular - pathology - secondaryen_HK
dc.subject.meshCell Line, Tumoren_HK
dc.subject.meshHumansen_HK
dc.subject.meshLiver Neoplasms - pathologyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshOligonucleotide Array Sequence Analysisen_HK
dc.subject.meshUp-Regulationen_HK
dc.subject.meshVimentin - genetics - physiologyen_HK
dc.titleAssociation of Vimentin overexpression and hepatocellular carcinoma metastasisen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0950-9232&volume=23&spage=298&epage=302&date=2004&atitle=Association+of+Vimentin+overexpression+and+hepatocellular+carcinoma+metastasis.en_HK
dc.identifier.emailGuan, XY:xyguan@hkucc.hku.hken_HK
dc.identifier.authorityGuan, XY=rp00454en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid14647434-
dc.identifier.scopuseid_2-s2.0-9144273731en_HK
dc.identifier.hkuros96100en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-9144273731&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume23en_HK
dc.identifier.issue1en_HK
dc.identifier.spage298en_HK
dc.identifier.epage302en_HK
dc.identifier.isiWOS:000187895300031-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridHu, L=34770075600en_HK
dc.identifier.scopusauthoridLau, SH=7401596190en_HK
dc.identifier.scopusauthoridTzang, CH=6508203245en_HK
dc.identifier.scopusauthoridWen, JM=7402701931en_HK
dc.identifier.scopusauthoridWang, W=36488756900en_HK
dc.identifier.scopusauthoridXie, D=35070710200en_HK
dc.identifier.scopusauthoridHuang, M=7404260307en_HK
dc.identifier.scopusauthoridWang, Y=7601486269en_HK
dc.identifier.scopusauthoridWu, MC=7405593399en_HK
dc.identifier.scopusauthoridHuang, JF=7407192439en_HK
dc.identifier.scopusauthoridZeng, WF=8338623800en_HK
dc.identifier.scopusauthoridSham, JST=7101655565en_HK
dc.identifier.scopusauthoridYang, M=7404925734en_HK
dc.identifier.scopusauthoridGuan, XY=7201463221en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats