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Article: Long-term sensorineural hearing deficit following radiotherapy in patients suffering from nasopharyngeal carcinoma: A prospective study

TitleLong-term sensorineural hearing deficit following radiotherapy in patients suffering from nasopharyngeal carcinoma: A prospective study
Authors
KeywordsDeafness
Long-term irradiation
Nasopharyngeal cancer
Issue Date1999
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38137
Citation
Head And Neck, 1999, v. 21 n. 6, p. 547-553 How to Cite?
AbstractBackground. This was a prospective study to evaluate the effect of radical external irradiation on inner ear function after treatment of nasopharyngeal carcinoma. Methods. Pure tone audiograms were performed at regular intervals before, after, and up to 4.5 years following completion of radiotherapy. Results. Two hundred ninety-four patients (526 ears) were included. Within 3 months after radiotherapy, deterioration of bone conduction threshold at 4 kHz and pure tone average (average of 0.5 kHz, 1 kHz, and 2 kHz) were noted in 164 ears (31%) and 75 ears (14%), respectively. Patients older than 50 years and ears with threshold below 60 dB at 4 kHz before radiotherapy were significant factors (p < 0.01 and p < 0.001) associated with a 4 kHz loss. In 40% of these ears, recovery was evident at 2 years. With follow-up for 4.5 years, the probability of significant threshold deterioration increased with time. Conclusion. Sensorineural hearing loss started soon after radiotherapy. Early changes could be reversible while the probability of persistent hearing loss continued to increase.
Persistent Identifierhttp://hdl.handle.net/10722/71886
ISSN
2015 Impact Factor: 2.76
2015 SCImago Journal Rankings: 1.233
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHo, WKen_HK
dc.contributor.authorWei, WIen_HK
dc.contributor.authorKwong, DLWen_HK
dc.contributor.authorSham, JSTen_HK
dc.contributor.authorTai, PTHen_HK
dc.contributor.authorYuen, APWen_HK
dc.contributor.authorAu, DKKen_HK
dc.date.accessioned2010-09-06T06:36:07Z-
dc.date.available2010-09-06T06:36:07Z-
dc.date.issued1999en_HK
dc.identifier.citationHead And Neck, 1999, v. 21 n. 6, p. 547-553en_HK
dc.identifier.issn1043-3074en_HK
dc.identifier.urihttp://hdl.handle.net/10722/71886-
dc.description.abstractBackground. This was a prospective study to evaluate the effect of radical external irradiation on inner ear function after treatment of nasopharyngeal carcinoma. Methods. Pure tone audiograms were performed at regular intervals before, after, and up to 4.5 years following completion of radiotherapy. Results. Two hundred ninety-four patients (526 ears) were included. Within 3 months after radiotherapy, deterioration of bone conduction threshold at 4 kHz and pure tone average (average of 0.5 kHz, 1 kHz, and 2 kHz) were noted in 164 ears (31%) and 75 ears (14%), respectively. Patients older than 50 years and ears with threshold below 60 dB at 4 kHz before radiotherapy were significant factors (p < 0.01 and p < 0.001) associated with a 4 kHz loss. In 40% of these ears, recovery was evident at 2 years. With follow-up for 4.5 years, the probability of significant threshold deterioration increased with time. Conclusion. Sensorineural hearing loss started soon after radiotherapy. Early changes could be reversible while the probability of persistent hearing loss continued to increase.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38137en_HK
dc.relation.ispartofHead and Necken_HK
dc.subjectDeafnessen_HK
dc.subjectLong-term irradiationen_HK
dc.subjectNasopharyngeal canceren_HK
dc.subject.meshAdolescenten_HK
dc.subject.meshAdulten_HK
dc.subject.meshAge Factorsen_HK
dc.subject.meshAgeden_HK
dc.subject.meshAged, 80 and overen_HK
dc.subject.meshAntineoplastic Combined Chemotherapy Protocols - therapeutic useen_HK
dc.subject.meshAudiometry, Pure-Toneen_HK
dc.subject.meshAuditory Threshold - radiation effectsen_HK
dc.subject.meshBone Conduction - radiation effectsen_HK
dc.subject.meshCarcinoma - drug therapy - radiotherapyen_HK
dc.subject.meshChemotherapy, Adjuvanten_HK
dc.subject.meshChi-Square Distributionen_HK
dc.subject.meshEar, Inner - radiation effectsen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshFollow-Up Studiesen_HK
dc.subject.meshHearing Loss, Sensorineural - etiologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLongitudinal Studiesen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshNasopharyngeal Neoplasms - drug therapy - radiotherapyen_HK
dc.subject.meshProbabilityen_HK
dc.subject.meshProspective Studiesen_HK
dc.subject.meshRadiation Injuries - etiologyen_HK
dc.subject.meshRadiotherapy Dosageen_HK
dc.subject.meshRecovery of Functionen_HK
dc.titleLong-term sensorineural hearing deficit following radiotherapy in patients suffering from nasopharyngeal carcinoma: A prospective studyen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0017-8748&volume=21&spage=547&epage=553&date=1999&atitle=Long-term+sensorineural+hearing+deficit+following+radiotherapy+in+patients+suffering+from+nasopharyngeal+carcinoma:+a+prospective+studyen_HK
dc.identifier.emailWei, WI: hrmswwi@hku.hken_HK
dc.identifier.emailKwong, DLW: dlwkwong@hku.hken_HK
dc.identifier.emailAu, DKK: kinkwau@hkucc.hku.hken_HK
dc.identifier.authorityWei, WI=rp00323en_HK
dc.identifier.authorityKwong, DLW=rp00414en_HK
dc.identifier.authorityAu, DKK=rp00385en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/(SICI)1097-0347(199909)21:6<547::AID-HED8>3.0.CO;2-Yen_HK
dc.identifier.pmid10449671-
dc.identifier.scopuseid_2-s2.0-0032884924en_HK
dc.identifier.hkuros47278en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032884924&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume21en_HK
dc.identifier.issue6en_HK
dc.identifier.spage547en_HK
dc.identifier.epage553en_HK
dc.identifier.isiWOS:000082366400008-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridHo, WK=7402968844en_HK
dc.identifier.scopusauthoridWei, WI=7403321552en_HK
dc.identifier.scopusauthoridKwong, DLW=15744231600en_HK
dc.identifier.scopusauthoridSham, JST=24472255400en_HK
dc.identifier.scopusauthoridTai, PTH=7103301238en_HK
dc.identifier.scopusauthoridYuen, APW=7006290111en_HK
dc.identifier.scopusauthoridAu, DKK=7004909224en_HK

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