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Article: In vitro inhibition of human immunodeficiency virus type-1 (HIV-1) reverse transcriptase by gold(III) porphyrins

TitleIn vitro inhibition of human immunodeficiency virus type-1 (HIV-1) reverse transcriptase by gold(III) porphyrins
Authors
KeywordsGold
HIV
Macrocyclic ligands
Porphyrinoids
Reverse transcriptase
Issue Date2004
PublisherWiley - V C H Verlag GmbH & Co KGaA. The Journal's web site is located at http://www.chembiochem.com
Citation
Chembiochem, 2004, v. 5 n. 9, p. 1293-1298 How to Cite?
AbstractA cationic gold(III) porphyrin, [AuIII(TM-PyP)]Cl5 (1 a), is a potent HIV-1 reverse transcriptase inhibitor in vitro with an IC 50 value = 0.31 μM. Effective inhibition (67%) can be produced by the "1 a + AZT-TP" protocol at nanomolar level. The gold(III) complex exhibits remarkable stability in physiological buffer without significant cytotoxicity to normal T cells.
Persistent Identifierhttp://hdl.handle.net/10722/70514
ISSN
2015 Impact Factor: 2.85
2015 SCImago Journal Rankings: 1.301
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSun, RWYen_HK
dc.contributor.authorYu, WYen_HK
dc.contributor.authorSun, Hen_HK
dc.contributor.authorChe, CMen_HK
dc.date.accessioned2010-09-06T06:23:35Z-
dc.date.available2010-09-06T06:23:35Z-
dc.date.issued2004en_HK
dc.identifier.citationChembiochem, 2004, v. 5 n. 9, p. 1293-1298en_HK
dc.identifier.issn1439-4227en_HK
dc.identifier.urihttp://hdl.handle.net/10722/70514-
dc.description.abstractA cationic gold(III) porphyrin, [AuIII(TM-PyP)]Cl5 (1 a), is a potent HIV-1 reverse transcriptase inhibitor in vitro with an IC 50 value = 0.31 μM. Effective inhibition (67%) can be produced by the "1 a + AZT-TP" protocol at nanomolar level. The gold(III) complex exhibits remarkable stability in physiological buffer without significant cytotoxicity to normal T cells.en_HK
dc.languageengen_HK
dc.publisherWiley - V C H Verlag GmbH & Co KGaA. The Journal's web site is located at http://www.chembiochem.comen_HK
dc.relation.ispartofChemBioChemen_HK
dc.subjectGolden_HK
dc.subjectHIVen_HK
dc.subjectMacrocyclic ligandsen_HK
dc.subjectPorphyrinoidsen_HK
dc.subjectReverse transcriptaseen_HK
dc.titleIn vitro inhibition of human immunodeficiency virus type-1 (HIV-1) reverse transcriptase by gold(III) porphyrinsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1439-4227&volume=5&issue=9&spage=1293&epage=1298&date=2004&atitle=In+vitro+inhibition+of+human+immunodeficiency+virus+type-1+(HIV-1)+reverse+transcriptase+by+gold(III)+porphyrinsen_HK
dc.identifier.emailSun, RWY:rwysun@hku.hken_HK
dc.identifier.emailSun, H:hsun@hkucc.hku.hken_HK
dc.identifier.emailChe, CM:cmche@hku.hken_HK
dc.identifier.authoritySun, RWY=rp00781en_HK
dc.identifier.authoritySun, H=rp00777en_HK
dc.identifier.authorityChe, CM=rp00670en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/cbic.200300773en_HK
dc.identifier.pmid15368585-
dc.identifier.scopuseid_2-s2.0-4644297701en_HK
dc.identifier.hkuros98604en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-4644297701&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume5en_HK
dc.identifier.issue9en_HK
dc.identifier.spage1293en_HK
dc.identifier.epage1298en_HK
dc.identifier.isiWOS:000223811800021-
dc.publisher.placeGermanyen_HK
dc.identifier.scopusauthoridSun, RWY=26325835800en_HK
dc.identifier.scopusauthoridYu, WY=7403913673en_HK
dc.identifier.scopusauthoridSun, H=7404827446en_HK
dc.identifier.scopusauthoridChe, CM=7102442791en_HK

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