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Article: Rapid reduction of pentavalent antimony by trypanothione: Potential relevance to antimonial activation

TitleRapid reduction of pentavalent antimony by trypanothione: Potential relevance to antimonial activation
Authors
Yan, SWong, ILKChow, LMCSun, H
Issue Date2003
PublisherRoyal Society of Chemistry. The Journal's web site is located at http://www.rsc.org/Publishing/Journals/cc/index.asp
Citation
Chemical Communications, 2003, v. 9 n. 2, p. 266-267 How to Cite?
DOI: http://dx.doi.org/10.1039/b210240d
AbstractThe dithiol trypanothione can reduce an antiparasitic pentavalent antimony agent to trivalent rapidly; this reduction process is both pH and temperature dependent and trypanothione may therefore play an important role in the activation of the drug.
Persistent Identifierhttp://hdl.handle.net/10722/70508
ISSN
1359-7345
2023 Impact Factor: 4.3
2023 SCImago Journal Rankings: 1.133
ISI Accession Number ID
WOS:000180249600046
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorYan, Sen_HK
dc.contributor.authorWong, ILKen_HK
dc.contributor.authorChow, LMCen_HK
dc.contributor.authorSun, Hen_HK
dc.date.accessioned2010-09-06T06:23:32Z-
dc.date.available2010-09-06T06:23:32Z-
dc.date.issued2003en_HK
dc.identifier.citationChemical Communications, 2003, v. 9 n. 2, p. 266-267en_HK
dc.identifier.issn1359-7345en_HK
dc.identifier.urihttp://hdl.handle.net/10722/70508-
dc.description.abstractThe dithiol trypanothione can reduce an antiparasitic pentavalent antimony agent to trivalent rapidly; this reduction process is both pH and temperature dependent and trypanothione may therefore play an important role in the activation of the drug.en_HK
dc.languageengen_HK
dc.publisherRoyal Society of Chemistry. The Journal's web site is located at http://www.rsc.org/Publishing/Journals/cc/index.aspen_HK
dc.relation.ispartofChemical Communicationsen_HK
dc.subject.meshAntimony - Chemistry-
dc.subject.meshAntiparasitic Agents - Chemistry-
dc.subject.meshGlutathione - Analogs & Derivatives - Chemistry-
dc.subject.meshHydrogen-Ion Concentration-
dc.subject.meshOxidation-Reduction-
dc.subject.meshSpermidine - Analogs & Derivatives - Chemistry-
dc.subject.meshStructure-Activity Relationship-
dc.subject.meshTemperature-
dc.titleRapid reduction of pentavalent antimony by trypanothione: Potential relevance to antimonial activationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1359-7345&volume=&spage=266&epage=267&date=2003&atitle=Rapid+reduction+of+pentavalent+antimony+by+trypanothione:++potential+relevance+to+antimonial+activationen_HK
dc.identifier.emailSun, H:hsun@hkucc.hku.hken_HK
dc.identifier.authoritySun, H=rp00777en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1039/b210240den_HK
dc.identifier.pmid12585423-
dc.identifier.scopuseid_2-s2.0-0037245060en_HK
dc.identifier.hkuros75920en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037245060&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume9en_HK
dc.identifier.issue2en_HK
dc.identifier.spage266en_HK
dc.identifier.epage267en_HK
dc.identifier.isiWOS:000180249600046-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridYan, S=7401744858en_HK
dc.identifier.scopusauthoridWong, ILK=7102513945en_HK
dc.identifier.scopusauthoridChow, LMC=7202533071en_HK
dc.identifier.scopusauthoridSun, H=7404827446en_HK
dc.identifier.issnl1359-7345-

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