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Article: Charge-remote fragmentation of odd-electron peptide ions
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TitleCharge-remote fragmentation of odd-electron peptide ions
 
AuthorsLaskin, J2
Yang, Z2
Lam, C1
Chu, IK1
 
Issue Date2007
 
PublisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/ac
 
CitationAnalytical Chemistry, 2007, v. 79 n. 17, p. 6607-6614 [How to Cite?]
DOI: http://dx.doi.org/10.1021/ac070777b
 
AbstractComparison between the gas-phase fragmentation of odd-electron M +., [M + H]2+., and [M - 2H]-. ions of model peptides suggests that charge-remote radical-driven fragmentation pathways play an important role in the dissociation of odd-electron peptide ions. We have found that charge-remote processes are responsible for a variety of side-chain losses from the precursor ion and some backbone fragmentation. These fragmentation pathways most likely involve hydrogen abstraction by the radical site that initiates subsequent cleavages. These findings are generally relevant to our understanding of the fragmentation patterns of odd-electron peptide ions produced through various approaches including the capture of low-energy electrons, electron detachment, and electron transfer. © 2007 American Chemical Society.
 
ISSN0003-2700
2012 Impact Factor: 5.695
2012 SCImago Journal Rankings: 2.289
 
DOIhttp://dx.doi.org/10.1021/ac070777b
 
ISI Accession Number IDWOS:000249242900030
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorLaskin, J
 
dc.contributor.authorYang, Z
 
dc.contributor.authorLam, C
 
dc.contributor.authorChu, IK
 
dc.date.accessioned2010-09-06T06:22:35Z
 
dc.date.available2010-09-06T06:22:35Z
 
dc.date.issued2007
 
dc.description.abstractComparison between the gas-phase fragmentation of odd-electron M +., [M + H]2+., and [M - 2H]-. ions of model peptides suggests that charge-remote radical-driven fragmentation pathways play an important role in the dissociation of odd-electron peptide ions. We have found that charge-remote processes are responsible for a variety of side-chain losses from the precursor ion and some backbone fragmentation. These fragmentation pathways most likely involve hydrogen abstraction by the radical site that initiates subsequent cleavages. These findings are generally relevant to our understanding of the fragmentation patterns of odd-electron peptide ions produced through various approaches including the capture of low-energy electrons, electron detachment, and electron transfer. © 2007 American Chemical Society.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationAnalytical Chemistry, 2007, v. 79 n. 17, p. 6607-6614 [How to Cite?]
DOI: http://dx.doi.org/10.1021/ac070777b
 
dc.identifier.doihttp://dx.doi.org/10.1021/ac070777b
 
dc.identifier.epage6614
 
dc.identifier.hkuros129874
 
dc.identifier.isiWOS:000249242900030
 
dc.identifier.issn0003-2700
2012 Impact Factor: 5.695
2012 SCImago Journal Rankings: 2.289
 
dc.identifier.issue17
 
dc.identifier.openurl
 
dc.identifier.pmid17676923
 
dc.identifier.scopuseid_2-s2.0-34548599820
 
dc.identifier.spage6607
 
dc.identifier.urihttp://hdl.handle.net/10722/70407
 
dc.identifier.volume79
 
dc.languageeng
 
dc.publisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/ac
 
dc.publisher.placeUnited States
 
dc.relation.ispartofAnalytical Chemistry
 
dc.relation.referencesReferences in Scopus
 
dc.titleCharge-remote fragmentation of odd-electron peptide ions
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong
  2. Pacific Northwest National Laboratory