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Article: Luminescent Tricarbonylrhenium(I) Dipyridoquinoxaline Iodine Complexes as Sensitive Probes for Indole-Binding Proteins

TitleLuminescent Tricarbonylrhenium(I) Dipyridoquinoxaline Iodine Complexes as Sensitive Probes for Indole-Binding Proteins
Authors
Issue Date2007
PublisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/organometallics
Citation
Organometallics, 2007, v. 26 n. 14, p. 3440-3447 How to Cite?
AbstractLuminescent tricarbonylrhenium(I) dipyridoquinoxaline indole complexes [Re(N−N)(CO)3(L)](CF3SO3) (N−N = dipyrido[3,2-f:2‘,3‘-h]quinoxaline (dpq), L = N-(3-pyridoyl)tryptamine (py-3-CONHC2H4-indole) (1a), N-(N-(3-pyridoyl)-6-aminohexanoyl)tryptamine (py-3-CONHC5H10CONHC2H4-indole) (1b); N−N = 2-(n-butylamido)dipyrido[3,2-f:2‘,3‘-h]quinoxaline (dpqa), L = py-3-CONHC2H4-indole (2a), py-3-CONHC5H10CONHC2H4-indole (2b)) and their indole-free counterparts [Re(N−N)(CO)3(py-3-CONH-Et)](CF3SO3) (py-3-CONH-Et = N-ethyl-(3-pyridyl)formamide; N−N = dpq (1c), dpqa (2c)) have been synthesized and characterized. The crystal structure of a related complex, [Re(dpqa)(CO)3(pyridine)](PF6), has also been studied. All the complexes exhibited triplet metal-to-ligand charge-transfer (3MLCT) (dπ(Re) → π*(N−N)) emission in fluid solutions at 298 K and in alcohol glass at 77 K. The emission quantum yields of the complexes were reduced upon changing from CH2Cl2 to aqueous buffer. The reduction was much more significant for the dpqa complexes than the dpq complexes due to the hydrogen-bonding interaction of the amide substituent of the dpqa ligand with water molecules. The interactions of these tricarbonylrhenium(I) complexes with indole-binding proteins including bovine serum albumin and tryptophanase have been studied by emission titrations and inhibition assays, respectively.
Persistent Identifierhttp://hdl.handle.net/10722/70403
ISSN
2015 Impact Factor: 4.186
2015 SCImago Journal Rankings: 2.043
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLo, KKWen_HK
dc.contributor.authorSze, KSen_HK
dc.contributor.authorTsang, KHKen_HK
dc.contributor.authorZhu, Nen_HK
dc.date.accessioned2010-09-06T06:22:33Z-
dc.date.available2010-09-06T06:22:33Z-
dc.date.issued2007en_HK
dc.identifier.citationOrganometallics, 2007, v. 26 n. 14, p. 3440-3447en_HK
dc.identifier.issn0276-7333en_HK
dc.identifier.urihttp://hdl.handle.net/10722/70403-
dc.description.abstractLuminescent tricarbonylrhenium(I) dipyridoquinoxaline indole complexes [Re(N−N)(CO)3(L)](CF3SO3) (N−N = dipyrido[3,2-f:2‘,3‘-h]quinoxaline (dpq), L = N-(3-pyridoyl)tryptamine (py-3-CONHC2H4-indole) (1a), N-(N-(3-pyridoyl)-6-aminohexanoyl)tryptamine (py-3-CONHC5H10CONHC2H4-indole) (1b); N−N = 2-(n-butylamido)dipyrido[3,2-f:2‘,3‘-h]quinoxaline (dpqa), L = py-3-CONHC2H4-indole (2a), py-3-CONHC5H10CONHC2H4-indole (2b)) and their indole-free counterparts [Re(N−N)(CO)3(py-3-CONH-Et)](CF3SO3) (py-3-CONH-Et = N-ethyl-(3-pyridyl)formamide; N−N = dpq (1c), dpqa (2c)) have been synthesized and characterized. The crystal structure of a related complex, [Re(dpqa)(CO)3(pyridine)](PF6), has also been studied. All the complexes exhibited triplet metal-to-ligand charge-transfer (3MLCT) (dπ(Re) → π*(N−N)) emission in fluid solutions at 298 K and in alcohol glass at 77 K. The emission quantum yields of the complexes were reduced upon changing from CH2Cl2 to aqueous buffer. The reduction was much more significant for the dpqa complexes than the dpq complexes due to the hydrogen-bonding interaction of the amide substituent of the dpqa ligand with water molecules. The interactions of these tricarbonylrhenium(I) complexes with indole-binding proteins including bovine serum albumin and tryptophanase have been studied by emission titrations and inhibition assays, respectively.-
dc.languageengen_HK
dc.publisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/organometallicsen_HK
dc.relation.ispartofOrganometallicsen_HK
dc.titleLuminescent Tricarbonylrhenium(I) Dipyridoquinoxaline Iodine Complexes as Sensitive Probes for Indole-Binding Proteinsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0276-7333&volume=&spage=3440&epage=3447&date=2007&atitle=Luminescent+Tricarbonylrhenium(I)+Dipyridoquinoxaline+Iodine+Complexes+as+Sensitive+Probes+for+Indole-Binding+Proteins+en_HK
dc.identifier.emailZhu, N: nzhu@hkucc.hku.hken_HK
dc.identifier.authorityZhu, N=rp00845en_HK
dc.identifier.doi10.1021/om0700617-
dc.identifier.hkuros143644en_HK
dc.identifier.volume26-
dc.identifier.issue14-
dc.identifier.spage3440-
dc.identifier.epage3447-
dc.identifier.isiWOS:000247436400025-
dc.publisher.placeUnited States-

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