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Article: Fluorophore-appended steroidal saponin (dioscin and polyphyllin D) derivatives

TitleFluorophore-appended steroidal saponin (dioscin and polyphyllin D) derivatives
Authors
Issue Date2005
PublisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/journals/orlef7/index.html
Citation
Organic Letters, 2005, v. 7 n. 4, p. 669-672 How to Cite?
Abstract(Chemical Equation Presented) The synthesis of three fluorophore-appended derivatives of dioscin and polyphyllin D is reported herein. Starting from trillin, dansyl derivatives A-C were prepared in overall yields of 7-12% over 7-10 steps. A study of their behavior in a variety of polar solvents suggests that dansyl derivatives A-C are capable of micellar self-assembly and can maintain cytotoxicities (IC 50 = 15-18 μM) against the HeLa carcinoma cell line evaluated by standard MTT assay. © 2005 American Chemical Society.
Persistent Identifierhttp://hdl.handle.net/10722/70370
ISSN
2015 Impact Factor: 6.732
2015 SCImago Journal Rankings: 3.187
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYang, Zen_HK
dc.contributor.authorWong, ELMen_HK
dc.contributor.authorShum, TYTen_HK
dc.contributor.authorChe, CMen_HK
dc.contributor.authorHui, Yen_HK
dc.date.accessioned2010-09-06T06:22:13Z-
dc.date.available2010-09-06T06:22:13Z-
dc.date.issued2005en_HK
dc.identifier.citationOrganic Letters, 2005, v. 7 n. 4, p. 669-672en_HK
dc.identifier.issn1523-7060en_HK
dc.identifier.urihttp://hdl.handle.net/10722/70370-
dc.description.abstract(Chemical Equation Presented) The synthesis of three fluorophore-appended derivatives of dioscin and polyphyllin D is reported herein. Starting from trillin, dansyl derivatives A-C were prepared in overall yields of 7-12% over 7-10 steps. A study of their behavior in a variety of polar solvents suggests that dansyl derivatives A-C are capable of micellar self-assembly and can maintain cytotoxicities (IC 50 = 15-18 μM) against the HeLa carcinoma cell line evaluated by standard MTT assay. © 2005 American Chemical Society.en_HK
dc.languageengen_HK
dc.publisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/journals/orlef7/index.htmlen_HK
dc.relation.ispartofOrganic Lettersen_HK
dc.titleFluorophore-appended steroidal saponin (dioscin and polyphyllin D) derivativesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1523-7060&volume=7&spage=669&epage=672&date=2005&atitle=Fluorophore-appended+steroidal+saponin+(Dioscin+and+Polyphyllin+D)+derivativesen_HK
dc.identifier.emailWong, ELM:wongella@hku.hken_HK
dc.identifier.emailChe, CM:cmche@hku.hken_HK
dc.identifier.authorityWong, ELM=rp00807en_HK
dc.identifier.authorityChe, CM=rp00670en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1021/ol0475616en_HK
dc.identifier.pmid15704921-
dc.identifier.scopuseid_2-s2.0-14844346999en_HK
dc.identifier.hkuros105842en_HK
dc.identifier.hkuros132318-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-14844346999&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume7en_HK
dc.identifier.issue4en_HK
dc.identifier.spage669en_HK
dc.identifier.epage672en_HK
dc.identifier.isiWOS:000226950100037-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridYang, Z=13205034800en_HK
dc.identifier.scopusauthoridWong, ELM=8944839700en_HK
dc.identifier.scopusauthoridShum, TYT=8922482200en_HK
dc.identifier.scopusauthoridChe, CM=7102442791en_HK
dc.identifier.scopusauthoridHui, Y=7103107588en_HK

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