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Article: Oxidative amide synthesis and N-terminal α-amino group ligation of peptides in aqueous medium

TitleOxidative amide synthesis and N-terminal α-amino group ligation of peptides in aqueous medium
Authors
Chan, WKHo, CMWong, MKChe, CM
Issue Date2006
PublisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/journals/jacsat/index.html
Citation
Journal Of The American Chemical Society, 2006, v. 128 n. 46, p. 14796-14797 How to Cite?
DOI: http://dx.doi.org/10.1021/ja064479s
AbstractA new method for oxidative synthesis of amides from alkynes and amines in high yields (up to 96%) using [Mn(2,6-Cl2TPP)Cl] 1 as a catalyst and Oxone/H2O2 as an oxidant in aqueous medium has been developed. This method could be used for N-terminal α-amino group ligation of unprotected peptides with aryl, aliphatic, and internal alkynes under mild conditions. Copyright © 2006 American Chemical Society.
Persistent Identifierhttp://hdl.handle.net/10722/70362
ISSN
0002-7863
2023 Impact Factor: 14.4
2023 SCImago Journal Rankings: 5.489
ISI Accession Number ID
WOS:000242021700031
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorChan, WKen_HK
dc.contributor.authorHo, CMen_HK
dc.contributor.authorWong, MKen_HK
dc.contributor.authorChe, CMen_HK
dc.date.accessioned2010-09-06T06:22:09Z-
dc.date.available2010-09-06T06:22:09Z-
dc.date.issued2006en_HK
dc.identifier.citationJournal Of The American Chemical Society, 2006, v. 128 n. 46, p. 14796-14797en_HK
dc.identifier.issn0002-7863en_HK
dc.identifier.urihttp://hdl.handle.net/10722/70362-
dc.description.abstractA new method for oxidative synthesis of amides from alkynes and amines in high yields (up to 96%) using [Mn(2,6-Cl2TPP)Cl] 1 as a catalyst and Oxone/H2O2 as an oxidant in aqueous medium has been developed. This method could be used for N-terminal α-amino group ligation of unprotected peptides with aryl, aliphatic, and internal alkynes under mild conditions. Copyright © 2006 American Chemical Society.en_HK
dc.languageengen_HK
dc.publisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/journals/jacsat/index.htmlen_HK
dc.relation.ispartofJournal of the American Chemical Societyen_HK
dc.titleOxidative amide synthesis and N-terminal α-amino group ligation of peptides in aqueous mediumen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0002-7863&volume=128&spage=14796&epage=&date=2006&atitle=Oxidative+amide+synthesis+and+N-terminal+alpha-amino+group+ligation+of+peptides+in+aqueous+mediumen_HK
dc.identifier.emailHo, CM: rickyho@hkucc.hku.hken_HK
dc.identifier.emailChe, CM: cmche@hku.hken_HK
dc.identifier.authorityHo, CM=rp00705en_HK
dc.identifier.authorityChe, CM=rp00670en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1021/ja064479sen_HK
dc.identifier.pmid17105276-
dc.identifier.scopuseid_2-s2.0-33845201456en_HK
dc.identifier.hkuros130236en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33845201456&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume128en_HK
dc.identifier.issue46en_HK
dc.identifier.spage14796en_HK
dc.identifier.epage14797en_HK
dc.identifier.isiWOS:000242021700031-
dc.publisher.placeUnited Statesen_HK
dc.identifier.f10001057787-
dc.identifier.scopusauthoridChan, WK=36545712200en_HK
dc.identifier.scopusauthoridHo, CM=12807243800en_HK
dc.identifier.scopusauthoridWong, MK=7403908449en_HK
dc.identifier.scopusauthoridChe, CM=7102442791en_HK
dc.identifier.issnl0002-7863-

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