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Article: Structure-based discovery of natural-product-like tnf-α inhibitors

TitleStructure-based discovery of natural-product-like tnf-α inhibitors
Authors
Chan, DSHLee, HMYang, FChe, CMWong, CCLAbagyan, RLeung, CHDikLung, M
KeywordsDrug discovery
Inhibitors
Natural products
Tumor necrosis factor
Virtual screening
Issue Date2010
PublisherWiley - V C H Verlag GmbH & Co. KGaA. The Journal's web site is located at http://www3.interscience.wiley.com/journal/26737/home
Citation
Angewandte Chemie - International Edition, 2010, v. 49 n. 16, p. 2860-2864 How to Cite?
DOI: http://dx.doi.org/10.1002/anie.200907360
Abstract(Figure Presented) Small but effective: Two natural-productlike inhibitors of tumor necrosis factor α (TNF-α represented in green in the picture) have been identified using structure-based virtual screening. These compounds represent only the third and fourth examples of direct targeting of TNF-α by a small molecule. and display potency comparable to that of the strongest TNF-α inhibitor reported to date. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.
Persistent Identifierhttp://hdl.handle.net/10722/70332
ISSN
1433-7851
2023 Impact Factor: 16.1
2023 SCImago Journal Rankings: 5.300
ISI Accession Number ID
WOS:000277131200005
Funding AgencyGrant Number
University Grants Committee of the Hong Kong Special Administrative Region ChinaAoE/P-10/01
University of Hong Kong (University Development Fund)
University of Hong Kong Seed Funding Programme
University of Hong Kong Seed Funding Programme for Basic Research
Funding Information:

This work was supported by the Area of Excellence Scheme established under the University Grants Committee of the Hong Kong Special Administrative Region China (AoE/P-10/01), the University of Hong Kong (University Development Fund), the University of Hong Kong Seed Funding Programme for Applied Research, and the University of Hong Kong Seed Funding Programme for Basic Research

References
References in Scopus
Grants
Institute of molecular technology for drug discovery and synthesis

 

DC FieldValueLanguage
dc.contributor.authorChan, DSHen_HK
dc.contributor.authorLee, HMen_HK
dc.contributor.authorYang, Fen_HK
dc.contributor.authorChe, CMen_HK
dc.contributor.authorWong, CCLen_HK
dc.contributor.authorAbagyan, Ren_HK
dc.contributor.authorLeung, CHen_HK
dc.contributor.authorDikLung, Men_HK
dc.date.accessioned2010-09-06T06:21:53Z-
dc.date.available2010-09-06T06:21:53Z-
dc.date.issued2010en_HK
dc.identifier.citationAngewandte Chemie - International Edition, 2010, v. 49 n. 16, p. 2860-2864en_HK
dc.identifier.issn1433-7851en_HK
dc.identifier.urihttp://hdl.handle.net/10722/70332-
dc.description.abstract(Figure Presented) Small but effective: Two natural-productlike inhibitors of tumor necrosis factor α (TNF-α represented in green in the picture) have been identified using structure-based virtual screening. These compounds represent only the third and fourth examples of direct targeting of TNF-α by a small molecule. and display potency comparable to that of the strongest TNF-α inhibitor reported to date. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.en_HK
dc.languageengen_HK
dc.publisherWiley - V C H Verlag GmbH & Co. KGaA. The Journal's web site is located at http://www3.interscience.wiley.com/journal/26737/homeen_HK
dc.relation.ispartofAngewandte Chemie - International Editionen_HK
dc.subjectDrug discoveryen_HK
dc.subjectInhibitorsen_HK
dc.subjectNatural productsen_HK
dc.subjectTumor necrosis factoren_HK
dc.subjectVirtual screeningen_HK
dc.titleStructure-based discovery of natural-product-like tnf-α inhibitorsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1433-7851&volume=49&issue=16&spage=2860&epage=2864&date=2010&atitle=Structure-Based+Discovery+of+Natural-Product-like+TNF-α+Inhibitorsen_HK
dc.identifier.emailChe, CM:cmche@hku.hken_HK
dc.identifier.emailLeung, CH:duncanl@hkucc.hku.hken_HK
dc.identifier.authorityChe, CM=rp00670en_HK
dc.identifier.authorityLeung, CH=rp00730en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/anie.200907360en_HK
dc.identifier.pmid20235259-
dc.identifier.scopuseid_2-s2.0-77950498477en_HK
dc.identifier.hkuros169872en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77950498477&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume49en_HK
dc.identifier.issue16en_HK
dc.identifier.spage2860en_HK
dc.identifier.epage2864en_HK
dc.identifier.isiWOS:000277131200005-
dc.publisher.placeGermanyen_HK
dc.relation.projectInstitute of molecular technology for drug discovery and synthesis-
dc.identifier.scopusauthoridChan, DSH=35285471900en_HK
dc.identifier.scopusauthoridLee, HM=35754627100en_HK
dc.identifier.scopusauthoridYang, F=13405459600en_HK
dc.identifier.scopusauthoridChe, CM=7102442791en_HK
dc.identifier.scopusauthoridWong, CCL=25937007700en_HK
dc.identifier.scopusauthoridAbagyan, R=7006710879en_HK
dc.identifier.scopusauthoridLeung, CH=7402612570en_HK
dc.identifier.scopusauthoridDikLung, M=23392107800en_HK
dc.identifier.issnl1433-7851-

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