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Article: Determination of dioxopromethazine hydrochloride by capillary electrophoresis with electrochemiluminescence detection

TitleDetermination of dioxopromethazine hydrochloride by capillary electrophoresis with electrochemiluminescence detection
Authors
KeywordsCapillary electrophoresis
Dioxopromethazine hydrochloride
Electrochemiluminescence detection
Issue Date2005
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/aca
Citation
Analytica Chimica Acta, 2005, v. 550 n. 1-2, p. 40-46 How to Cite?
AbstractThe paper presents a rapid method for the determination of dioxopromethazine hydrochloride (DPZ), an antihistamine drug, by the capillary electrophoresis with electrochemiluminescene detection (CE-ECL) using tris(2,2′-bipyridyl)ruthenium(II) (Ru(bpy)3 2+) reagent. This CE-ECL detection method has high sensitivity, good selectivity and reproducibility for DPZ analysis. Under the optimized conditions: separation capillary, 38 cm length (25 μm i.d.); sample injection, 10 s at 8 kV; separation voltage, 12.5 kV; running buffer, 20 mmol L-1 sodium phosphate of pH 6.0; detection potential, 1.15 V; 50 mmol L-1 of phosphate buffer (pH 7.14) containing 5 mmol L-1 of Ru(bpy) 3 2+ in ECL detection cell, the detection limit of DPZ was 0.05 μmol L-1 (S/N = 3). The linear range extended from 5 to 100 μmol L-1. The linear curve obtained was Y = 181.62 + 9.28X with a correlation coefficient of 0.9970. The relative standard deviations of the ECL intensity and the migration time for six continuous injections of 5 μmol L-1 DPZ were 3.7% and 0.92%, respectively. The CE-ECL method was applied to analyze DPZ in real samples including tablets, rat serum and human urine, and satisfactory results were obtained without interference from samples matrix. The CE-ECL technique was proved to be a potential method for the detection of DPZ in clinic analysis. © 2005 Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/70328
ISSN
2015 Impact Factor: 4.712
2015 SCImago Journal Rankings: 1.548
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLi, Yen_HK
dc.contributor.authorWang, Cen_HK
dc.contributor.authorSun, Jen_HK
dc.contributor.authorZhou, Yen_HK
dc.contributor.authorYou, Ten_HK
dc.contributor.authorWang, Een_HK
dc.contributor.authorFung, Yen_HK
dc.date.accessioned2010-09-06T06:21:50Z-
dc.date.available2010-09-06T06:21:50Z-
dc.date.issued2005en_HK
dc.identifier.citationAnalytica Chimica Acta, 2005, v. 550 n. 1-2, p. 40-46en_HK
dc.identifier.issn0003-2670en_HK
dc.identifier.urihttp://hdl.handle.net/10722/70328-
dc.description.abstractThe paper presents a rapid method for the determination of dioxopromethazine hydrochloride (DPZ), an antihistamine drug, by the capillary electrophoresis with electrochemiluminescene detection (CE-ECL) using tris(2,2′-bipyridyl)ruthenium(II) (Ru(bpy)3 2+) reagent. This CE-ECL detection method has high sensitivity, good selectivity and reproducibility for DPZ analysis. Under the optimized conditions: separation capillary, 38 cm length (25 μm i.d.); sample injection, 10 s at 8 kV; separation voltage, 12.5 kV; running buffer, 20 mmol L-1 sodium phosphate of pH 6.0; detection potential, 1.15 V; 50 mmol L-1 of phosphate buffer (pH 7.14) containing 5 mmol L-1 of Ru(bpy) 3 2+ in ECL detection cell, the detection limit of DPZ was 0.05 μmol L-1 (S/N = 3). The linear range extended from 5 to 100 μmol L-1. The linear curve obtained was Y = 181.62 + 9.28X with a correlation coefficient of 0.9970. The relative standard deviations of the ECL intensity and the migration time for six continuous injections of 5 μmol L-1 DPZ were 3.7% and 0.92%, respectively. The CE-ECL method was applied to analyze DPZ in real samples including tablets, rat serum and human urine, and satisfactory results were obtained without interference from samples matrix. The CE-ECL technique was proved to be a potential method for the detection of DPZ in clinic analysis. © 2005 Elsevier B.V. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/acaen_HK
dc.relation.ispartofAnalytica Chimica Actaen_HK
dc.subjectCapillary electrophoresisen_HK
dc.subjectDioxopromethazine hydrochlorideen_HK
dc.subjectElectrochemiluminescence detectionen_HK
dc.titleDetermination of dioxopromethazine hydrochloride by capillary electrophoresis with electrochemiluminescence detectionen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0003-2697&volume=550&spage=40&epage=46&date=2005&atitle=Determination+of+dioxopromethazine+hydrochloride+by+capillary+electrophoresis+with+electrochemiluminescence+detectionen_HK
dc.identifier.emailFung, Y:ysfung@hku.hken_HK
dc.identifier.authorityFung, Y=rp00697en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.aca.2005.06.045en_HK
dc.identifier.scopuseid_2-s2.0-24944513071en_HK
dc.identifier.hkuros124189en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-24944513071&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume550en_HK
dc.identifier.issue1-2en_HK
dc.identifier.spage40en_HK
dc.identifier.epage46en_HK
dc.identifier.isiWOS:000232356200006-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridLi, Y=12753262100en_HK
dc.identifier.scopusauthoridWang, C=8208296700en_HK
dc.identifier.scopusauthoridSun, J=8855551800en_HK
dc.identifier.scopusauthoridZhou, Y=12773941200en_HK
dc.identifier.scopusauthoridYou, T=7005598624en_HK
dc.identifier.scopusauthoridWang, E=7403414218en_HK
dc.identifier.scopusauthoridFung, Y=13309754700en_HK

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