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Article: Computational Prediction on Mammalian and Viral MicroRNAs - a Review

TitleComputational Prediction on Mammalian and Viral MicroRNAs - a Review
Authors
KeywordsMicroRNAs
Computational predction
Machine-learning
Phylogenetic conservation
Comparative genomics
Issue Date2007
PublisherOmics Group. The Journal's web site is located at http://wwwclassicruscom/IJIB/
Citation
International Journal of Integrative Biology, 2007, v. 1 n. 2, p. 118-126 How to Cite?
AbstractMicroRNAs (miRNAs) are small non-coding RNA gene products of 19-25 nt long, which can repress the translation of their target mRNAs. Mammalian and viral miRNAs have identified diversified biological roles including developmental timing and left/right asymmetry of chemoreceptor expression in nematodes, programmed cell death in Drosophila, hematopoietic differentiation in mammals, apoptosis and metabolism in insects, cellular proliferation and immune response inhibition in viruses. Over the past 2 years, researches on the roles of miRNAs in cancers have been increasing, suggesting that miRNA is a valuable potential therapeutic target in human diseases. Here we review the currently available computational approaches for the prediction of mammalian and viral miRNA. Some popular miRNA online resources of the miRNA computational prediction approaches are introduced and discussed.
Persistent Identifierhttp://hdl.handle.net/10722/70211
ISSN
2015 SCImago Journal Rankings: 0.142

 

DC FieldValueLanguage
dc.contributor.authorLeung, WSen_HK
dc.contributor.authorYiu, SMen_HK
dc.contributor.authorCheung, DWen_HK
dc.contributor.authorLai, Len_HK
dc.contributor.authorLin, MCen_HK
dc.contributor.authorKung, HFen_HK
dc.date.accessioned2010-09-06T06:20:46Z-
dc.date.available2010-09-06T06:20:46Z-
dc.date.issued2007en_HK
dc.identifier.citationInternational Journal of Integrative Biology, 2007, v. 1 n. 2, p. 118-126en_HK
dc.identifier.issn0973-8363en_HK
dc.identifier.urihttp://hdl.handle.net/10722/70211-
dc.description.abstractMicroRNAs (miRNAs) are small non-coding RNA gene products of 19-25 nt long, which can repress the translation of their target mRNAs. Mammalian and viral miRNAs have identified diversified biological roles including developmental timing and left/right asymmetry of chemoreceptor expression in nematodes, programmed cell death in Drosophila, hematopoietic differentiation in mammals, apoptosis and metabolism in insects, cellular proliferation and immune response inhibition in viruses. Over the past 2 years, researches on the roles of miRNAs in cancers have been increasing, suggesting that miRNA is a valuable potential therapeutic target in human diseases. Here we review the currently available computational approaches for the prediction of mammalian and viral miRNA. Some popular miRNA online resources of the miRNA computational prediction approaches are introduced and discussed.-
dc.languageengen_HK
dc.publisherOmics Group. The Journal's web site is located at http://wwwclassicruscom/IJIB/en_HK
dc.relation.ispartofInternational Journal of Integrative Biologyen_HK
dc.subjectMicroRNAs-
dc.subjectComputational predction-
dc.subjectMachine-learning-
dc.subjectPhylogenetic conservation-
dc.subjectComparative genomics-
dc.titleComputational Prediction on Mammalian and Viral MicroRNAs - a Reviewen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0973-8363&volume=1&issue=2&spage=118&epage=126&date=2007&atitle=Computational+Prediction+on+Mammalian+and+Viral+MicroRNAs+-+a+Reviewen_HK
dc.identifier.emailYiu, SM: smyiu@cs.hku.hken_HK
dc.identifier.emailCheung, DWL: dcheung@cs.hku.hken_HK
dc.identifier.emailLin, MC: mcllin@HKUCC.hku.hken_HK
dc.identifier.authorityYiu, SM=rp00207en_HK
dc.identifier.authorityCheung, DWL=rp00101en_HK
dc.identifier.authorityLin, MC=rp00746en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.hkuros145156en_HK

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