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Article: Targeted drug delivery via the transferrin receptor-mediated endocytosis pathway

TitleTargeted drug delivery via the transferrin receptor-mediated endocytosis pathway
Authors
Issue Date2002
PublisherAmerican Society for Pharmacology and Experimental Therapeutics. The Journal's web site is located at http://www.pharmrev.org/
Citation
Pharmacological Reviews, 2002, v. 54 n. 4, p. 561-587 How to Cite?
AbstractThe membrane transferrin receptor-mediated endocytosis or internalization of the complex of transferrin bound iron and the transferrin receptor is the major route of cellular iron uptake. This efficient cellular uptake pathway has been exploited for the site-specific delivery not only of anticancer drugs and proteins, but also of therapeutic genes into proliferating malignant cells that overexpress the transferrin receptors. This is achieved either chemically by conjugation of transferrin with therapeutic drugs, proteins, or genetically by infusion of therapeutic peptides or proteins into the structure of transferrin. The resulting conjugates significantly improve the cytotoxicity and selectivity of the drugs. The coupling of DNA to transferrin via a polycation or liposome serves as a potential alternative to viral vector for gene therapy. Moreover, the OX26 monoclonal antibody against the rat transferrin receptor offers great promise in the delivery of therapeutic agents across the blood-brain barrier to the brain.
Persistent Identifierhttp://hdl.handle.net/10722/70149
ISSN
2015 Impact Factor: 18.393
2015 SCImago Journal Rankings: 8.937
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorQian, ZMen_HK
dc.contributor.authorLi, Hen_HK
dc.contributor.authorSun, Hen_HK
dc.contributor.authorHo, Ken_HK
dc.date.accessioned2010-09-06T06:20:10Z-
dc.date.available2010-09-06T06:20:10Z-
dc.date.issued2002en_HK
dc.identifier.citationPharmacological Reviews, 2002, v. 54 n. 4, p. 561-587en_HK
dc.identifier.issn0031-6997en_HK
dc.identifier.urihttp://hdl.handle.net/10722/70149-
dc.description.abstractThe membrane transferrin receptor-mediated endocytosis or internalization of the complex of transferrin bound iron and the transferrin receptor is the major route of cellular iron uptake. This efficient cellular uptake pathway has been exploited for the site-specific delivery not only of anticancer drugs and proteins, but also of therapeutic genes into proliferating malignant cells that overexpress the transferrin receptors. This is achieved either chemically by conjugation of transferrin with therapeutic drugs, proteins, or genetically by infusion of therapeutic peptides or proteins into the structure of transferrin. The resulting conjugates significantly improve the cytotoxicity and selectivity of the drugs. The coupling of DNA to transferrin via a polycation or liposome serves as a potential alternative to viral vector for gene therapy. Moreover, the OX26 monoclonal antibody against the rat transferrin receptor offers great promise in the delivery of therapeutic agents across the blood-brain barrier to the brain.en_HK
dc.languageengen_HK
dc.publisherAmerican Society for Pharmacology and Experimental Therapeutics. The Journal's web site is located at http://www.pharmrev.org/en_HK
dc.relation.ispartofPharmacological Reviewsen_HK
dc.titleTargeted drug delivery via the transferrin receptor-mediated endocytosis pathwayen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0031-6997&volume=54&issue=4&spage=561&epage=587&date=2002&atitle=Targeted+drug+delivery+via+the+transferrin+receptor-mediated+endocytosis+pathwayen_HK
dc.identifier.emailSun, H:hsun@hkucc.hku.hken_HK
dc.identifier.authoritySun, H=rp00777en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1124/pr.54.4.561en_HK
dc.identifier.pmid12429868-
dc.identifier.scopuseid_2-s2.0-0036889760en_HK
dc.identifier.hkuros75923en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036889760&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume54en_HK
dc.identifier.issue4en_HK
dc.identifier.spage561en_HK
dc.identifier.epage587en_HK
dc.identifier.isiWOS:000179388700001-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridQian, ZM=7201384672en_HK
dc.identifier.scopusauthoridLi, H=14023043100en_HK
dc.identifier.scopusauthoridSun, H=7404827446en_HK
dc.identifier.scopusauthoridHo, K=7403581513en_HK

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