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Article: Nucleic acid intercalators and avidin probes derived from luminescent cyclometalated iridium(III)-dipyridoquinoxaline and -dipyridophenazine complexes

TitleNucleic acid intercalators and avidin probes derived from luminescent cyclometalated iridium(III)-dipyridoquinoxaline and -dipyridophenazine complexes
Authors
KeywordsAvidin
Biotin
DNA
Indium
Luminescence
Issue Date2006
PublisherWiley - V C H Verlag GmbH & Co KGaA. The Journal's web site is located at http://www.wiley-vch.de/home/chemistry
Citation
Chemistry - A European Journal, 2006, v. 12 n. 5, p. 1500-1512 How to Cite?
AbstractSix luminescent cyclometalated iridium(III)-dipyridoquinoxaline and -dipyridophenazine complexes [Ir-(ppy)2(N-N)](PF6) (Hppy = 2-phenyl-pyridine; N-N = dipyrido[3,2-f:2′,3′-h]quinoxaline, dpq (1); 2-n-butylamido-dipyrido[3,2-f:2′,3′-h]quinoxaline, dpqa (2); 2-((2-biotinamido)ethyl)amidodi-pyrido[3,2-f:2′,3′-h]quinoxaline, dpqB (3); dipyrido[3,2-a:2′,3′-c]phenazine, dppz (4); benzo[i]dipyrido[3,2-a:2′,3′-c]phenazine, dppn (5); 11-((2-biotin amido)ethyl)amidodipyrido[3,2-a:2′,3′-c]-phenazine, dppzB (6)) have been designed as luminescent intercalators for DNA and probes for avidin. The structure of complex 4 has been studied by X-ray crystallography. The photophysical and electrochemical properties of the complexes have also been investi gated. The binding of these complexes to double-stranded calf thymus DNA and synthetic double-stranded oligonucleotides poly(dA)·poly(dT) and poly-(dG)·poly(dC) has been investigated by spectroscopic titrations. The interactions between the two biotin-containing complexes and avidin have been studied by 4′-hydroxyazobenzene-2-carboxylic acid (HABA) assays and emission titrations. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
Persistent Identifierhttp://hdl.handle.net/10722/70118
ISSN
2015 Impact Factor: 5.771
2015 SCImago Journal Rankings: 2.323
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLo, KKWen_HK
dc.contributor.authorChung, CKen_HK
dc.contributor.authorZhu, Nen_HK
dc.date.accessioned2010-09-06T06:19:53Z-
dc.date.available2010-09-06T06:19:53Z-
dc.date.issued2006en_HK
dc.identifier.citationChemistry - A European Journal, 2006, v. 12 n. 5, p. 1500-1512en_HK
dc.identifier.issn0947-6539en_HK
dc.identifier.urihttp://hdl.handle.net/10722/70118-
dc.description.abstractSix luminescent cyclometalated iridium(III)-dipyridoquinoxaline and -dipyridophenazine complexes [Ir-(ppy)2(N-N)](PF6) (Hppy = 2-phenyl-pyridine; N-N = dipyrido[3,2-f:2′,3′-h]quinoxaline, dpq (1); 2-n-butylamido-dipyrido[3,2-f:2′,3′-h]quinoxaline, dpqa (2); 2-((2-biotinamido)ethyl)amidodi-pyrido[3,2-f:2′,3′-h]quinoxaline, dpqB (3); dipyrido[3,2-a:2′,3′-c]phenazine, dppz (4); benzo[i]dipyrido[3,2-a:2′,3′-c]phenazine, dppn (5); 11-((2-biotin amido)ethyl)amidodipyrido[3,2-a:2′,3′-c]-phenazine, dppzB (6)) have been designed as luminescent intercalators for DNA and probes for avidin. The structure of complex 4 has been studied by X-ray crystallography. The photophysical and electrochemical properties of the complexes have also been investi gated. The binding of these complexes to double-stranded calf thymus DNA and synthetic double-stranded oligonucleotides poly(dA)·poly(dT) and poly-(dG)·poly(dC) has been investigated by spectroscopic titrations. The interactions between the two biotin-containing complexes and avidin have been studied by 4′-hydroxyazobenzene-2-carboxylic acid (HABA) assays and emission titrations. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.en_HK
dc.languageengen_HK
dc.publisherWiley - V C H Verlag GmbH & Co KGaA. The Journal's web site is located at http://www.wiley-vch.de/home/chemistryen_HK
dc.relation.ispartofChemistry - A European Journalen_HK
dc.subjectAvidinen_HK
dc.subjectBiotinen_HK
dc.subjectDNAen_HK
dc.subjectIndiumen_HK
dc.subjectLuminescenceen_HK
dc.titleNucleic acid intercalators and avidin probes derived from luminescent cyclometalated iridium(III)-dipyridoquinoxaline and -dipyridophenazine complexesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0947-6539&volume=12&issue=5&spage=1500&epage=1512&date=2006&atitle=Nucleic+acid+intercalators+and+avidin+probes+derived+from+luminescent+cyclometalated+iridium(III)-dipyridoquinoxaline+and+-dipyridophenazine+complexesen_HK
dc.identifier.emailZhu, N: nzhu@hkucc.hku.hken_HK
dc.identifier.authorityZhu, N=rp00845en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/chem.200500885en_HK
dc.identifier.pmid16304644-
dc.identifier.scopuseid_2-s2.0-32044434180en_HK
dc.identifier.hkuros117545en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-32044434180&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume12en_HK
dc.identifier.issue5en_HK
dc.identifier.spage1500en_HK
dc.identifier.epage1512en_HK
dc.identifier.isiWOS:000235285600021-
dc.publisher.placeGermanyen_HK
dc.identifier.scopusauthoridLo, KKW=26032181200en_HK
dc.identifier.scopusauthoridChung, CK=7403613700en_HK
dc.identifier.scopusauthoridZhu, N=7201449530en_HK

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