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Article: A highly selective fluorescent probe for the detection and imaging of peroxynitrite in living cells

TitleA highly selective fluorescent probe for the detection and imaging of peroxynitrite in living cells
Authors
Issue Date2006
PublisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/journals/jacsat/index.html
Citation
Journal Of The American Chemical Society, 2006, v. 128 n. 18, p. 6004-6005 How to Cite?
AbstractWe have found a specific reaction between ketone 1 and peroxynitrite (ONOO-), rather than other reactive oxygen species and reactive nitrogen species generated in the biological system. On the basis of this reaction, we have successfully developed a new fluorescent probe HKGreen-1, which is highly selective for the detection of peroxynitrite in living cells. Before the oxidation with peroxynitrite, the dichlorofluorescein part is masked and the probe is nonfluorescent. However, upon reaction with peroxynitrite, the fluorophore is released, resulting in strong enhancement in fluorescence intensity. Copyright © 2006 American Chemical Society.
Persistent Identifierhttp://hdl.handle.net/10722/70062
ISSN
2015 Impact Factor: 13.038
2015 SCImago Journal Rankings: 7.123
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYang, Den_HK
dc.contributor.authorWang, HLen_HK
dc.contributor.authorSun, ZNen_HK
dc.contributor.authorChung, NWen_HK
dc.contributor.authorShen, JGen_HK
dc.date.accessioned2010-09-06T06:19:21Z-
dc.date.available2010-09-06T06:19:21Z-
dc.date.issued2006en_HK
dc.identifier.citationJournal Of The American Chemical Society, 2006, v. 128 n. 18, p. 6004-6005en_HK
dc.identifier.issn0002-7863en_HK
dc.identifier.urihttp://hdl.handle.net/10722/70062-
dc.description.abstractWe have found a specific reaction between ketone 1 and peroxynitrite (ONOO-), rather than other reactive oxygen species and reactive nitrogen species generated in the biological system. On the basis of this reaction, we have successfully developed a new fluorescent probe HKGreen-1, which is highly selective for the detection of peroxynitrite in living cells. Before the oxidation with peroxynitrite, the dichlorofluorescein part is masked and the probe is nonfluorescent. However, upon reaction with peroxynitrite, the fluorophore is released, resulting in strong enhancement in fluorescence intensity. Copyright © 2006 American Chemical Society.en_HK
dc.languageengen_HK
dc.publisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/journals/jacsat/index.htmlen_HK
dc.relation.ispartofJournal of the American Chemical Societyen_HK
dc.titleA highly selective fluorescent probe for the detection and imaging of peroxynitrite in living cellsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0002-7863&volume=128&spage=6004&epage=6005&date=2006&atitle=A+highly+selective+fluorescent+probe+for+the+detection+and+imaging+of+peroxynitrite+in+living+cells+en_HK
dc.identifier.emailYang, D: yangdan@hku.hken_HK
dc.identifier.emailSun, ZN: znsun@hku.hken_HK
dc.identifier.emailShen, JG: shenjg@hku.hken_HK
dc.identifier.authorityYang, D=rp00825en_HK
dc.identifier.authoritySun, ZN=rp00782en_HK
dc.identifier.authorityShen, JG=rp00487en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1021/ja0603756en_HK
dc.identifier.pmid16669647-
dc.identifier.scopuseid_2-s2.0-33646505308en_HK
dc.identifier.hkuros122024en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33646505308&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume128en_HK
dc.identifier.issue18en_HK
dc.identifier.spage6004en_HK
dc.identifier.epage6005en_HK
dc.identifier.isiWOS:000237468900011-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridYang, D=7404800756en_HK
dc.identifier.scopusauthoridWang, HL=35604926700en_HK
dc.identifier.scopusauthoridSun, ZN=25029021500en_HK
dc.identifier.scopusauthoridChung, NW=8759035900en_HK
dc.identifier.scopusauthoridShen, JG=7404929947en_HK

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